AutismKB 2.0

Annotation Detail for RAPGEF4


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Basic Information Top
Gene Symbol:RAPGEF4 ( CAMP-GEFII,CGEF2,EPAC2,Nbla00496 )
Gene Full Name: Rap guanine nucleotide exchange factor (GEF) 4
Band: 2q31.1
Quick LinksEntrez ID:11069; OMIM: 606058; Uniprot ID:RPGF4_HUMAN; ENSEMBL ID: ENSG00000091428; HGNC ID: 16626
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
681Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
11Phosphoserine(CK1)HMM predict
12Phosphoserine(CK1)HMM predict
27Phosphoserine(CK1)HMM predict
93Phosphoserine(CK2)HMM predict
96Phosphoserine(CK1)HMM predict
180Phosphothreonine(MAPK)HMM predict
251S-palmitoylHMM predict
301Phosphothreonine(PKC)HMM predict
363Phosphothreonine(PKC)HMM predict
464Phosphothreonine(PKC)HMM predict
498Phosphotyrosine(Syk)HMM predict
559Phosphoserine(ATM)HMM predict
569Phosphotyrosine(INSR)HMM predict
606Phosphotyrosine(Jak)HMM predict
752Phosphothreonine(MAPK)HMM predict
783SulfotyrosineHMM predict
893Phosphotyrosine(EGFR)HMM predict
912Phosphothreonine(PKC)HMM predict
938N-linkedHMM predict
944N-linkedHMM predict
1000Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_007023
  • Location:chr2 173308852-173625860
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 173308178 173308950 772 289
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 173630254 173630432 178 4483
p63 keratinocytesGSE17611 173635831 173636471 640 10291
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 173430599 173431081 482 0
CTCF CD4GSE12889 173379486 173379775 289 0
CTCF CD4GSE12889 173437311 173437468 157 0
CTCF CD4GSE12889 173504833 173505298 465 0
CTCF CD4GSE12889 173545006 173545253 247 0
CTCF CD4GSE12889 173600419 173600850 431 0
CTCF CD4SISSRdata 173379486 173379775 289 0
CTCF CD4SISSRdata 173437311 173437468 157 0
CTCF CD4SISSRdata 173504833 173505298 465 0
CTCF CD4SISSRdata 173545006 173545253 247 0
CTCF CD4SISSRdata 173600419 173600850 431 0
CTCF HelaGSE12889 173545074 173545358 284 0
CTCF G2GSE9613 173309259 173309572 313 0
CTCF G2GSE9613 173352394 173352593 199 0
CTCF G2GSE9613 173379320 173379739 419 0
CTCF G2GSE9613 173437123 173437560 437 0
CTCF G2GSE9613 173458790 173458968 178 0
CTCF G2GSE9613 173474986 173475234 248 0
CTCF G2GSE9613 173504516 173505110 594 0
CTCF G2GSE9613 173540192 173540657 465 0
CTCF G2GSE9613 173544980 173545526 546 0
CTCF G2GSE9613 173600307 173600685 378 0
ER Fulvestrant-MCF7GSE14664 173380639 173380686 47 0
ER Fulvestrant-MCF7GSE14664 173590074 173590111 37 0
FOXA1 MCF7GSE15244 173416744 173417280 536 0
FOXA1 MCF7GSE15244 173610583 173611398 815 0
FOXA1 MCF7GSE15244 173617400 173618114 714 0
FOXA1 MCF7GSE15244 173624470 173625004 534 0
Fos K562GSE19551 173621613 173622770 1157 0
FoxA1 MCF7MACSdata 173611289 173611504 215 0
NFkBII GM12878GSE19485 173481975 173483220 1245 0
Nanog hESGSE18292 173479386 173479535 149 0
Nanog hESGSE18292 173609418 173609778 360 0
Oct1 H2O2-HelaGSE14283 173391461 173391489 28 0
Oct1 H2O2-HelaGSE14283 173496479 173496508 29 0
Oct1 H2O2-HelaGSE14283 173533294 173533322 28 0
Oct1 H2O2-HelaGSE14283 173536006 173536036 30 0
Oct1 HelaGSE14283 173368793 173368874 81 0
Oct1 HelaGSE14283 173391410 173391525 115 0
Oct1 HelaGSE14283 173402467 173402498 31 0
Oct1 HelaGSE14283 173496468 173496525 57 0
Oct1 HelaGSE14283 173533294 173533323 29 0
Oct1 HelaGSE14283 173538223 173538260 37 0
Oct1 HelaGSE14283 173589345 173589379 34 0
P300 T0-glioblastomaGSE21026 173621291 173623369 2078 0
P300 T30-glioblastomaGSE21026 173540774 173541562 788 0
P300 T30-glioblastomaGSE21026 173557994 173559491 1497 0
P300 T30-glioblastomaGSE21026 173568404 173570199 1795 0
P300 T30-glioblastomaGSE21026 173620963 173623289 2326 0
PolII HeLaGSE12783 173432482 173434614 2132 0
RARA MCF7GSE15244 173355705 173356879 1174 0
RARA MCF7GSE15244 173623611 173625041 1430 0
RNAII Tamoxifen-MCF7GSE14664 173376268 173376368 100 0
RNAII Tamoxifen-MCF7GSE14664 173377986 173378074 88 0
RNAII Tamoxifen-MCF7GSE14664 173391457 173391496 39 0
RNAII Tamoxifen-MCF7GSE14664 173496471 173496517 46 0
SRF HelaGSE8489 173568554 173569936 1382 0
STAT1 HeLaGSE12783 173558222 173559719 1497 0
TAF k562GSE8489 173492304 173493017 713 0
TFAP2C MCF7GSE21234 173361930 173362222 292 0
TFAP2C MCF7GSE21234 173460345 173460748 403 0
TFAP2C MCF7GSE21234 173526792 173527527 735 0
TFAP2C MCF7GSE21234 173558450 173559111 661 0
TFAP2C MCF7GSE21234 173624097 173624995 898 0
hScc1 BcellGSE12603 173308649 173309295 646 0
hScc1 BcellGSE12603 173379320 173379814 494 0
hScc1 BcellGSE12603 173437123 173437560 437 0
hScc1 BcellGSE12603 173504848 173505214 366 0
hScc1 BcellGSE12603 173545182 173545352 170 0
hScc1 BcellGSE12603 173546381 173546638 257 0
hScc1 BcellGSE12603 173600307 173601012 705 0
hScc1 CdLSGSE12603 173379244 173379850 606 0
hScc1 CdLSGSE12603 173437050 173437560 510 0
hScc1 CdLSGSE12603 173504667 173505286 619 0
hScc1 CdLSGSE12603 173600262 173601051 789 0
hScc1 G2GSE9613 173379177 173380178 1001 0
hScc1 G2GSE9613 173437159 173437560 401 0
hScc1 G2GSE9613 173600215 173600943 728 0
p63 keratinocytesGSE17611 173379830 173380532 702 0
p63 keratinocytesGSE17611 173430645 173431641 996 0
p63 keratinocytesGSE17611 173515670 173516343 673 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15285 mRNA RAPGEF4 chr2 173426113 173743122 328 mRNA LOC91149 chr2 173413424 173426441 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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