AutismKB 2.0

Annotation Detail for CHD4


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Basic Information Top
Gene Symbol:CHD4 ( DKFZp686E06161,Mi-2b,Mi2-BETA )
Gene Full Name: chromodomain helicase DNA binding protein 4
Band: 12p13.31
Quick LinksEntrez ID:1108; OMIM: 603277; Uniprot ID:CHD4_HUMAN; ENSEMBL ID: ENSG00000111642; HGNC ID: 1919
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
103Phosphoserine.
428Phosphoserine.
515Phosphoserine.
517Phosphothreonine.
529Phosphothreonine.
531Phosphoserine.
876DEAH box.
987N6-acetyllysine.
1308Phosphoserine (By similarity).
1349Phosphoserine.
1370Phosphoserine.
1531Phosphoserine.
1535Phosphoserine.
1537Phosphoserine.
1540Phosphothreonine (By similarity).
1542Phosphothreonine.
1545Phosphothreonine (By similarity).
1549Phosphothreonine (By similarity).
1553Phosphothreonine.
1570Phosphoserine.
1576Phosphoserine.
1602Phosphoserine.
1643N6-acetyllysine.
Location(AA) Modifications Resource
44PhosphoserinePhospho.ELM 6.0
103Phosphoserine.Swiss-Prot 53.0
103PhosphoserinePhospho.ELM 6.0
308PhosphoserinePhospho.ELM 6.0
309PhosphoserinePhospho.ELM 6.0
310PhosphoserinePhospho.ELM 6.0
319PhosphoserinePhospho.ELM 6.0
428Phosphoserine.Swiss-Prot 53.0
428PhosphoserinePhospho.ELM 6.0
515PhosphoserinePhospho.ELM 6.0
515Phosphoserine.Swiss-Prot 53.0
517PhosphothreoninePhospho.ELM 6.0
531PhosphoserinePhospho.ELM 6.0
531Phosphoserine.Swiss-Prot 53.0
1531PhosphoserinePhospho.ELM 6.0
1531Phosphoserine.Swiss-Prot 53.0
1535PhosphoserinePhospho.ELM 6.0
1535Phosphoserine.Swiss-Prot 53.0
1537PhosphoserinePhospho.ELM 6.0
1537Phosphoserine.Swiss-Prot 53.0
1540Phosphothreonine (By similarity).Swiss-Prot 53.0
1545Phosphothreonine (By similarity).Swiss-Prot 53.0
1549Phosphothreonine (By similarity).Swiss-Prot 53.0
1602Phosphoserine.Swiss-Prot 53.0
1602PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphoserine(CDC2)HMM predict
7Phosphoserine(CDK)HMM predict
15Phosphoserine(CK2)HMM predict
25N-linkedHMM predict
26N-linkedHMM predict
44Phosphoserine(CK2)HMM predict
44Phosphoserine(CK1)HMM predict
48Phosphothreonine(CDC2)HMM predict
108Phosphoserine(CK1)HMM predict
110Phosphotyrosine(INSR)HMM predict
111Phosphothreonine(CDK)HMM predict
111Phosphothreonine(CDC2)HMM predict
168Phosphoserine(CK1)HMM predict
172Phosphotyrosine(EGFR)HMM predict
172Phosphotyrosine(Syk)HMM predict
277Phosphoserine(CDC2)HMM predict
308Phosphoserine(PKG)HMM predict
309Phosphoserine(PKC)HMM predict
309Phosphoserine(PKG)HMM predict
309Phosphoserine(CK2)HMM predict
310Phosphoserine(CK2)HMM predict
310Phosphoserine(CK1)HMM predict
319Phosphoserine(CK2)HMM predict
332Phosphoserine(ATM)HMM predict
348Phosphothreonine(PKC)HMM predict
428Phosphoserine(CK2)HMM predict
467S-palmitoylHMM predict
493S-palmitoylHMM predict
515Phosphoserine(IKK)HMM predict
515Phosphoserine(MAPK)HMM predict
515Phosphoserine(CDC2)HMM predict
517O-linkedHMM predict
517Phosphothreonine(CDK)HMM predict
529Phosphothreonine(MAPK)HMM predict
531Phosphoserine(CDC2)HMM predict
531Phosphoserine(MAPK)HMM predict
664SulfotyrosineHMM predict
703O-linkedHMM predict
705O-linkedHMM predict
709O-linkedHMM predict
802Phosphotyrosine(Jak)HMM predict
881N-linkedHMM predict
1023Phosphotyrosine(Abl)HMM predict
1091Phosphotyrosine(Jak)HMM predict
1209Phosphoserine(IKK)HMM predict
1308Phosphoserine(CK2)HMM predict
1322SulfotyrosineHMM predict
1360Phosphoserine(CK1)HMM predict
1360Phosphoserine(ATM)HMM predict
1362N-linkedHMM predict
1366Phosphotyrosine(INSR)HMM predict
1388Phosphoserine(PKA)HMM predict
1388Phosphoserine(PKA)HMM predict
1388Phosphoserine(PKG)HMM predict
1535Phosphoserine(IKK)HMM predict
1535Phosphoserine(ATM)HMM predict
1535Phosphoserine(CDC2)HMM predict
1537Phosphoserine(CDC2)HMM predict
1537O-linkedHMM predict
1537Phosphoserine(CDK)HMM predict
1540O-linkedHMM predict
1540Phosphothreonine(MAPK)HMM predict
1542O-linkedHMM predict
1544O-linkedHMM predict
1545O-linkedHMM predict
1545Phosphothreonine(CDK)HMM predict
1545PhosphothreonineHMM predict
1545Phosphothreonine(MAPK)HMM predict
1549O-linkedHMM predict
1553O-linkedHMM predict
1553Phosphothreonine(MAPK)HMM predict
1576Phosphoserine(CK1)HMM predict
1595O-linkedHMM predict
1595O-linkedHMM predict
1720Phosphothreonine(PKC)HMM predict
1758Phosphotyrosine(Jak)HMM predict
1806N-linkedHMM predict
1812Phosphoserine(IKK)HMM predict
1904O-linkedHMM predict
1904Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001273
  • Location:chr12 6549509-6586811
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 6586562 6587208 646 74
CTCF G2GSE9613 6592102 6592694 592 5587
FOXA1 MCF7GSE15244 6586980 6587405 425 381
FOXA1 MCF7GSE15244 6588418 6588778 360 1787
H3K4me2 HCT116GSE10453 6586980 6589136 2156 1247
H3K4me2 HCT116GSE10453 6591211 6592286 1075 4937
H3ac HepG2E 6591033 6593029 1996 5220
USF1 HepG2E 6587865 6589107 1242 1675
USF1 HepG2E 6591033 6593488 2455 5449
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 6549768 6549954 186 0
CTCF CD4SISSRdata 6549768 6549954 186 0
CTCF G2GSE9613 6549321 6550356 1035 0
CTCF G2GSE9613 6560958 6561277 319 0
CTCF G2GSE9613 6561579 6562063 484 0
CTCF G2GSE9613 6582523 6582998 475 0
CTCF G2GSE9613 6584583 6585968 1385 0
FOXA1 MCF7GSE15244 6585149 6585437 288 0
H3K4me2 HCT116GSE10453 6584249 6585544 1295 0
H3ac HepG2E 6583104 6583400 296 0
H3ac HepG2E 6583733 6585624 1891 0
NRSF pAbJurkat 6560994 6561277 283 0
NRSF pAbJurkat 6582480 6583067 587 0
Oct1 H2O2-HelaGSE14283 6577365 6577395 30 0
PHF8 HeLaGSE20725 6585591 6586947 1356 0
Pol2 GM12878GSE19551 6586574 6587013 439 0
Rb shRbQuiescentGSE19898 6581533 6581759 226 0
hScc1 BcellGSE12603 6584985 6585921 936 0
hScc1 G2GSE9613 6585892 6587061 1169 0
p130 SenescentGSE19898 6585056 6585333 277 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-205 hsa-mir-205 1 20065103
hsa-miR-224 hsa-mir-224 X 20065103
hsa-miR-335 hsa-mir-335 7 20065103
hsa-miR-335* hsa-mir-335 7 20065103
hsa-miR-424 hsa-mir-424 X 20065103
hsa-miR-424* hsa-mir-424 X 20065103
hsa-miR-451 hsa-mir-451 17 20065103
hsa-miR-491-3p hsa-mir-491 9 20065103
hsa-miR-491-5p hsa-mir-491 9 20065103
hsa-miR-93 hsa-mir-93 7 20065103
hsa-miR-93* hsa-mir-93 7 20065103
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
5575 mRNA chr12 6558048 6564166 462 mRNA CHD4 chr12 6549509 6586812Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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