AutismKB 2.0

Annotation Detail for CIT


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Basic Information Top
Gene Symbol:CIT ( CRIK,KIAA0949,STK21 )
Gene Full Name: citron (rho-interacting, serine/threonine kinase 21)
Band: 12q24.23
Quick LinksEntrez ID:11113; OMIM: 605629; Uniprot ID:CTRO_HUMAN; ENSEMBL ID: ENSG00000122966; HGNC ID: 1985
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
433Phosphoserine.
440Phosphoserine.
480Phosphoserine (By similarity).
1196Phosphotyrosine (By similarity).
1478Phosphotyrosine (By similarity).
1582Phosphoserine (By similarity).
1721N6-acetyllysine.
1958SH3-binding (Potential).
1971Phosphoserine.
1993Phosphoserine.
Location(AA) Modifications Resource
440Phosphoserine.Swiss-Prot 53.0
440PhosphoserinePhospho.ELM 6.0
480Phosphoserine (By similarity).Swiss-Prot 53.0
1582Phosphoserine (By similarity).Swiss-Prot 53.0
1971Phosphoserine.Swiss-Prot 53.0
1971PhosphoserinePhospho.ELM 6.0
1993Phosphoserine.Swiss-Prot 53.0
1993PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
63Phosphoserine(ATM)HMM predict
154Phosphoserine(CDC2)HMM predict
154Phosphoserine(IKK)HMM predict
171Phosphotyrosine(INSR)HMM predict
263PhosphotyrosineHMM predict
263Phosphotyrosine(Syk)HMM predict
263Phosphotyrosine(INSR)HMM predict
263Phosphotyrosine(SRC)HMM predict
355S-palmitoylHMM predict
356S-palmitoylHMM predict
395Phosphoserine(IKK)HMM predict
407Phosphoserine(ATM)HMM predict
433Phosphoserine(IKK)HMM predict
433Phosphoserine(PKB)HMM predict
440Phosphoserine(CDC2)HMM predict
440Phosphoserine(CDK)HMM predict
480Phosphoserine(PKG)HMM predict
498Phosphothreonine(PKC)HMM predict
516Phosphoserine(CK1)HMM predict
529Phosphoserine(ATM)HMM predict
529PhosphoserineHMM predict
557Phosphotyrosine(SRC)HMM predict
557Phosphotyrosine(EGFR)HMM predict
624Phosphotyrosine(INSR)HMM predict
682Phosphoserine(CK1)HMM predict
721Phosphotyrosine(EGFR)HMM predict
793N-linkedHMM predict
818Phosphotyrosine(Jak)HMM predict
888Phosphoserine(CK1)HMM predict
1007Phosphoserine(ATM)HMM predict
1007Phosphoserine(IKK)HMM predict
1011Phosphothreonine(PKC)HMM predict
1118Phosphoserine(CK1)HMM predict
1144Phosphothreonine(PKC)HMM predict
1196Phosphotyrosine(INSR)HMM predict
1217Phosphoserine(ATM)HMM predict
1305O-linkedHMM predict
1305O-linkedHMM predict
1306Phosphothreonine(CDK)HMM predict
1331Phosphoserine(IKK)HMM predict
1338O-linkedHMM predict
1343Phosphoserine(PKA)HMM predict
1343Phosphoserine(PKB)HMM predict
1343Phosphoserine(PKG)HMM predict
1343Phosphoserine(CK2)HMM predict
1344Phosphoserine(PKG)HMM predict
1344Phosphoserine(CK2)HMM predict
1345Phosphothreonine(MAPK)HMM predict
1399S-palmitoylHMM predict
1443Phosphoserine(CK1)HMM predict
1534O-linkedHMM predict
1568Phosphoserine(PKG)HMM predict
1595N-linkedHMM predict
1614Phosphotyrosine(INSR)HMM predict
1665Phosphoserine(PKG)HMM predict
1665Phosphoserine(IKK)HMM predict
1678Phosphoserine(ATM)HMM predict
1718N-linkedHMM predict
1820Phosphothreonine(PKA)HMM predict
1860Phosphothreonine(CDC2)HMM predict
1897S-palmitoylHMM predict
1898S-palmitoylHMM predict
1915Phosphoserine(PKB)HMM predict
1916Phosphothreonine(PKC)HMM predict
1917O-linkedHMM predict
1920Phosphoserine(CDC2)HMM predict
1929Phosphotyrosine(Abl)HMM predict
1929Phosphotyrosine(EGFR)HMM predict
1939O-linkedHMM predict
1940Phosphoserine(IKK)HMM predict
1940O-linkedHMM predict
1940Phosphoserine(CDK)HMM predict
1940Phosphoserine(CDC2)HMM predict
1971Phosphoserine(CDC2)HMM predict
1981Phosphoserine(CDC2)HMM predict
1993Phosphoserine(CDC2)HMM predict
2013Phosphothreonine(MAPK)HMM predict
2013Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_007174
  • Location:chr12 118607980-118799474
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 SGSE7516 118799127 118800008 881 93
ER E2-MCF7GSE14664 118814311 118814348 37 14855
Fos K562GSE19551 118799331 118799937 606 160
LIN54 G0GSE7516 118799280 118800008 728 170
Oct1 HelaGSE14283 118814308 118814351 43 14855
Oct1 HelaGSE14283 118815440 118815471 31 15981
P300 T30-glioblastomaGSE21026 118804452 118805095 643 5299
Rb GrowingGSE19898 118799527 118799922 395 250
Rb QuiescentGSE19898 118799650 118799856 206 279
Rb SenescentGSE19898 118799595 118799860 265 253
TFAP2C MCF7GSE21234 118799324 118800073 749 224
p130 QuiescentGSE19898 118799004 118800012 1008 34
p130 shRbQuiescentGSE19898 118799049 118800015 966 58
p130 SGSE7516 118799127 118800008 881 93
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 118659383 118659699 316 0
CBP T30-glioblastomaGSE21026 118638321 118639329 1008 0
CTCF G2GSE9613 118609033 118609739 706 0
CTCF G2GSE9613 118612204 118612725 521 0
CTCF G2GSE9613 118620018 118620264 246 0
CTCF G2GSE9613 118630281 118630601 320 0
CTCF G2GSE9613 118634682 118635170 488 0
CTCF G2GSE9613 118674175 118674506 331 0
CTCF G2GSE9613 118677910 118678064 154 0
CTCF G2GSE9613 118701756 118701928 172 0
CTCF G2GSE9613 118702814 118703503 689 0
CTCF G2GSE9613 118713404 118713657 253 0
CTCF G2GSE9613 118721668 118721856 188 0
CTCF G2GSE9613 118726374 118727020 646 0
CTCF G2GSE9613 118738592 118738950 358 0
CTCF G2GSE9613 118765423 118765677 254 0
CTCF G2GSE9613 118798939 118800008 1069 0
E2F4 G0GSE7516 118798903 118800008 1105 0
ER Fulvestrant-MCF7GSE14664 118705865 118705956 91 0
FOXA1 DLD1GSE12801 118615094 118615574 480 0
FOXA1 DLD1GSE12801 118638607 118638847 240 0
FOXA1 DLD1GSE12801 118702814 118703201 387 0
FOXA1 DLD1GSE12801 118778975 118779657 682 0
FOXA1 DLD1GSE12801 118791276 118791835 559 0
FOXA1 MCF7GSE15244 118608627 118609485 858 0
FOXA1 MCF7GSE15244 118632745 118633813 1068 0
FOXA1 MCF7GSE15244 118638607 118638847 240 0
Fos K562GSE19551 118726379 118726867 488 0
GATA3 MCF7GSE15244 118608094 118609640 1546 0
H3ac HepG2E 118798190 118799713 1523 0
LIN9 G0GSE7516 118798614 118800008 1394 0
LIN9 SGSE7516 118798752 118800008 1256 0
Myc K562GSE19551 118762837 118763187 350 0
NRSF pAbJurkat 118612395 118612827 432 0
NRSF pAbJurkat 118640380 118640553 173 0
Oct1 HelaGSE14283 118614259 118614336 77 0
Oct1 HelaGSE14283 118669125 118669155 30 0
Oct1 HelaGSE14283 118703016 118703048 32 0
Oct1 HelaGSE14283 118730193 118730230 37 0
Oct1 HelaGSE14283 118780141 118780168 27 0
P300 T0-glioblastomaGSE21026 118638211 118639181 970 0
P300 T30-glioblastomaGSE21026 118638416 118639507 1091 0
PHF8 293TGSE20725 118798850 118799965 1115 0
PHF8 HeLaGSE20725 118798836 118799978 1142 0
RARA MCF7GSE15244 118608335 118609485 1150 0
RARA MCF7GSE15244 118632565 118633462 897 0
RARA MCF7GSE15244 118638607 118638847 240 0
RARA MCF7GSE15244 118702814 118703503 689 0
RARG MCF7GSE15244 118608441 118609350 909 0
RARG MCF7GSE15244 118632108 118633782 1674 0
RARG MCF7GSE15244 118637941 118638234 293 0
RARG MCF7GSE15244 118638607 118638847 240 0
RNAII Tamoxifen-MCF7GSE14664 118703015 118703049 34 0
Rb GrowingGSE19898 118726649 118726768 119 0
Rb SenescentGSE19898 118799181 118799458 277 0
TAF HelaGSE8489 118658974 118659109 135 0
hScc1 BcellGSE12603 118634156 118634369 213 0
hScc1 BcellGSE12603 118662810 118663077 267 0
hScc1 BcellGSE12603 118726374 118726804 430 0
p130 SenescentGSE19898 118791192 118791928 736 0
p130 SenescentGSE19898 118791981 118792494 513 0
p130 SenescentGSE19898 118798711 118800201 1490 0
p130 shRbSenescentGSE19898 118791419 118792540 1121 0
p130 shRbSenescentGSE19898 118798771 118800119 1348 0
p130 G0GSE7516 118798654 118800008 1354 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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