Annotation Detail for PWP1

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Basic Information Top

Gene Symbol:	PWP1 ( IEF-SSP-9502 )
Gene Full Name:	PWP1 homolog (S. cerevisiae)
Band:	12q23.3
Quick Links	Entrez ID:11137; OMIM: NA; Uniprot ID:PWP1_HUMAN; ENSEMBL ID: ENSG00000136045; HGNC ID: 17015
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
1	N-acetylmethionine.
21	Phosphothreonine.
50	Phosphoserine.
55	Phosphothreonine.
57	Phosphoserine.
59	Phosphoserine.
65	Phosphoserine.
86	Phosphothreonine.
485	Phosphoserine.
494	Phosphoserine (By similarity).

Location(AA)	Modifications	Resource
50	Phosphoserine.	Swiss-Prot 53.0
50	Phosphoserine	Phospho.ELM 6.0
57	Phosphoserine.	Swiss-Prot 53.0
57	Phosphoserine	Phospho.ELM 6.0
86	Phosphothreonine.	Swiss-Prot 53.0
86	Phosphothreonine	Phospho.ELM 6.0
494	Phosphoserine (By similarity).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	106594288	106594506	218	9323
CTCF	CD4	SISSRdata	106594288	106594506	218	9323
CTCF	G2	GSE9613	106594313	106594895	582	9116
CTCF	G2	GSE9613	106595289	106595677	388	8237
ETS1	Jurkat	GSE17954	106602939	106604348	1409	76
FOXA1	MCF7	GSE15244	106602458	106604073	1615	454
H3ac	HepG2	E	106602420	106603554	1134	733
Nanog	hES	GSE18292	106594296	106594598	302	9273
Nanog	hES	GSE18292	106603071	106603245	174	562
PHF8	HeLa	GSE20725	106603135	106604295	1160	5
RARA	MCF7	GSE15244	106602493	106603587	1094	680
RARG	MCF7	GSE15244	106602493	106603961	1468	493
Sox2	hES	GSE18292	106603076	106603463	387	450
TAF	Hela	GSE8489	106602777	106603884	1107	389
TAF	k562	GSE8489	106602420	106603554	1134	733
USF1	HepG2	E	106602420	106603701	1281	659
USF2	HepG2	E	106602420	106603587	1167	716
hScc1	Bcell	GSE12603	106594313	106594895	582	9116
hScc1	CdLS	GSE12603	106594313	106594895	582	9116
hScc1	G2	GSE9613	106594313	106594895	582	9116
p130	Senescent	GSE19898	106602875	106603278	403	643

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	106603483	106604037	554
H3ac	HepG2	E	106603961	106604556	595
H3ac	HepG2	E	106604916	106605262	346
Myc	K562	GSE19551	106603267	106604296	1029
Oct1	H2O2-Hela	GSE14283	106612783	106612825	42
Oct1	Hela	GSE14283	106612776	106612823	47
P300	T30-glioblastoma	GSE21026	106603118	106604333	1215
PHF8	Hs68minusFBS	GSE20725	106603220	106604415	1195
Rb	Senescent	GSE19898	106603824	106603954	130
TAFII	hES	GSE17917	106603475	106604133	658
p130	Quiescent	GSE19898	106603412	106604067	655
p130	shRbQuiescent	GSE19898	106603303	106604288	985

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1191	Unknown	pSILAC	miR-1	PWP1	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000136045		n_a	n_a	n_a	"squamous cell, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018