AutismKB 2.0

Annotation Detail for MAP4K5


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Basic Information Top
Gene Symbol:MAP4K5 ( GCKR,KHS,KHS1,MAPKKKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 5
Band: 14q22.1
Quick LinksEntrez ID:11183; OMIM: 604923; Uniprot ID:M4K5_HUMAN; ENSEMBL ID: ENSG00000012983; HGNC ID: 6867
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
31Phosphotyrosine.
335Phosphoserine.
401Phosphotyrosine.
Location(AA) Modifications Resource
335Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
20Phosphotyrosine(Syk)HMM predict
31Phosphotyrosine(SRC)HMM predict
31Phosphotyrosine(INSR)HMM predict
267Phosphothreonine(PKC)HMM predict
267Phosphothreonine(PKA)HMM predict
303SulfotyrosineHMM predict
335Phosphoserine(CAMK2)HMM predict
379Phosphothreonine(PKC)HMM predict
383Phosphothreonine(PKC)HMM predict
400Phosphoserine(PKB)HMM predict
414Phosphothreonine(PKC)HMM predict
433Phosphoserine(IKK)HMM predict
561N-linkedHMM predict
562N-linkedHMM predict
598Phosphothreonine(PKC)HMM predict
625S-palmitoylHMM predict
626S-palmitoylHMM predict
670Phosphoserine(CDC2)HMM predict
827O-linkedHMM predict
829N-linkedHMM predict
835N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006575
  • Location:chr14 49954996-50069125
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 50078477 50078685 208 9456
CTCF CD4GSE12889 50068966 50069365 399 40
CTCF CD4GSE12889 50079404 50079712 308 10433
CTCF CD4SISSRdata 50068966 50069365 399 40
CTCF CD4SISSRdata 50079404 50079712 308 10433
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 50068803 50069445 642 0
ER E2-MCF7GSE14664 49986759 49986831 72 0
ER E2-MCF7GSE14664 50012610 50012672 62 0
ER E2-MCF7GSE14664 50021515 50021577 62 0
ER Fulvestrant-MCF7GSE14664 49986776 49986829 53 0
Fos K562GSE19551 50057844 50058285 441 0
H3K4me3 colorectalcancer 50067430 50068473 1043 0
H3ac HepG2E 50066225 50068473 2248 0
Myc K562GSE19551 50068798 50069395 597 0
NRSF-mono JurkatQuESTdata 49988383 49988604 221 0
NRSF-poly JurkatQuESTdata 49988333 49988630 297 0
Oct1 H2O2-HelaGSE14283 50009840 50009870 30 0
Oct1 H2O2-HelaGSE14283 50009966 50009993 27 0
Oct1 H2O2-HelaGSE14283 50011827 50011857 30 0
Oct1 HelaGSE14283 50011827 50011857 30 0
Oct1 HelaGSE14283 50012604 50012672 68 0
P300 T30-glioblastomaGSE21026 50057715 50058992 1277 0
RNAII Tamoxifen-MCF7GSE14664 50012593 50012648 55 0
TAF k562GSE8489 50067859 50068330 471 0
TFAP2C MCF7GSE21234 50011952 50012249 297 0
hScc1 BcellGSE12603 50068204 50069445 1241 0
hScc1 CdLSGSE12603 50068167 50069513 1346 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018