AutismKB 2.0

Annotation Detail for MAP4K1


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Basic Information Top
Gene Symbol:MAP4K1 ( HPK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 1
Band: 19q13.1-q13.4
Quick LinksEntrez ID:11184; OMIM: 601983; Uniprot ID:M4K1_HUMAN; ENSEMBL ID: ENSG00000104814; HGNC ID: 6863
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
324Phosphoserine.
366Phosphoserine.
368Phosphoserine.
374Phosphoserine.
376Phosphoserine.
377Phosphoserine.
381Phosphotyrosine.
405Phosphoserine.
407Phosphoserine.
413Phosphoserine.
421Phosphoserine.
586Phosphoserine.
Location(AA) Modifications Resource
165PhosphothreoninePhospho.ELM 6.0
171PhosphoserinePhospho.ELM 6.0
366PhosphoserinePhospho.ELM 6.0
366Phosphoserine.Swiss-Prot 53.0
368Phosphoserine.Swiss-Prot 53.0
368PhosphoserinePhospho.ELM 6.0
374Phosphoserine.Swiss-Prot 53.0
376Phosphoserine.Swiss-Prot 53.0
381Phosphotyrosine.Swiss-Prot 53.0
381Phosphotyrosine (Syk)Phospho.ELM 6.0
407Phosphoserine.Swiss-Prot 53.0
413Phosphoserine.Swiss-Prot 53.0
421Phosphoserine.Swiss-Prot 53.0
586Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
28Phosphotyrosine(EGFR)HMM predict
103Phosphotyrosine(Syk)HMM predict
130Phosphoserine(ATM)HMM predict
232Phosphotyrosine(INSR)HMM predict
258Phosphoserine(CDK)HMM predict
258Phosphoserine(CDK)HMM predict
258PhosphoserineHMM predict
258Phosphoserine(CDC2)HMM predict
320Phosphoserine(PKB)HMM predict
326Phosphoserine(CK1)HMM predict
368Phosphoserine(CDK)HMM predict
368Phosphoserine(CDC2)HMM predict
374Phosphoserine(CK2)HMM predict
376Phosphoserine(CK2)HMM predict
376Phosphoserine(CK2)HMM predict
377Phosphoserine(CK2)HMM predict
377Phosphoserine(CK1)HMM predict
381SulfotyrosineHMM predict
381Phosphotyrosine(Syk)HMM predict
381Phosphotyrosine(INSR)HMM predict
393Phosphothreonine(CDK)HMM predict
393Phosphothreonine(MAPK)HMM predict
405Phosphoserine(CDC2)HMM predict
407O-linkedHMM predict
430O-linkedHMM predict
436O-linkedHMM predict
436Phosphoserine(CDC2)HMM predict
436Phosphoserine(MAPK)HMM predict
436PhosphoserineHMM predict
438MethylarginineHMM predict
444O-linkedHMM predict
445O-linkedHMM predict
446O-linkedHMM predict
447Phosphoserine(IKK)HMM predict
447O-linkedHMM predict
556Phosphoserine(ATM)HMM predict
576Phosphothreonine(PKA)HMM predict
618Phosphoserine(ATM)HMM predict
655Phosphothreonine(MAPK)HMM predict
678Phosphoserine(CDC2)HMM predict
733Phosphothreonine(MAPK)HMM predict
737PhosphoserineHMM predict
820Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001042600
  • Location:chr19 43770120-43800482
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 43799675 43802232 2557 471
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 43778563 43778782 219 0
hScc1 BcellGSE12603 43782378 43782632 254 0
hScc1 BcellGSE12603 43783728 43784023 295 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
13176 EST chr19 43778825 43784174 235 mRNA MAP4K1 chr19 43770120 43800404Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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