Annotation Detail for CHKA

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	CHKA ( CHK,CK,CKI,EK )
Gene Full Name:	choline kinase alpha
Band:	11q13.2
Quick Links	Entrez ID:1119; OMIM: 118491; Uniprot ID:CHKA_HUMAN; ENSEMBL ID: ENSG00000110721; HGNC ID: 1937
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:7 results

No data

Location(AA)	Modification	Resource
87	Phosphothreonine(PKC)	HMM predict
162	Phosphoserine(CK2)	HMM predict
291	Phosphoserine(CK1)	HMM predict
298	Phosphoserine(MAPK)	HMM predict
356	Sulfotyrosine	HMM predict
420	C-linked	HMM predict
431	Phosphoserine(PKG)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001277
Location:chr11 67576903-67645433
strand:-

Upstream the gene:17 results
Downstream the gene:1 results
Inside the gene:16 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Fos	K562	GSE19551	67645371	67645834	463	169
H3ac	HepG2	E	67646918	67647387	469	1719
H3ac	HepG2	E	67648588	67649432	844	3577
H3ac	HepG2	E	67653099	67653818	719	8025
Myc	K562	GSE19551	67652463	67653210	747	7403
NRSF	Jurkat	GSE13047	67645557	67646601	1044	646
NRSF-mono	Jurkat	QuESTdata	67645309	67646556	1247	499
NRSF	pAb	Jurkat	67651769	67651897	128	6400
NRSF-poly	Jurkat	QuESTdata	67645485	67646553	1068	586
PHF8	HeLa	GSE20725	67644786	67646531	1745	225
PHF8	Hs68plusFBS	GSE20725	67644488	67646411	1923	16
TFAP2C	MCF7	GSE21234	67645568	67646042	474	372
USF1	HepG2	E	67648588	67649397	809	3559
USF1	HepG2	E	67650159	67651005	846	5149
USF1	HepG2	E	67653465	67653818	353	8208
USF2	HepG2	E	67650230	67651005	775	5184
hScc1	CdLS	GSE12603	67645398	67646011	613	271

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
NRSF	pAb	Jurkat	67575895	67576465	570	724

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K4me3	colorectal	cancer	67644308	67644637	329	0
H3ac	HepG2	E	67623593	67624325	732	0
H3ac	HepG2	E	67629914	67630225	311	0
H3ac	HepG2	E	67631421	67632158	737	0
H3ac	HepG2	E	67640799	67641339	540	0
H3ac	HepG2	E	67641751	67642176	425	0
H3ac	HepG2	E	67642500	67643489	989	0
H3ac	HepG2	E	67644308	67644637	329	0
NFkBII	GM10847	GSE19485	67644152	67646557	2405	0
Oct1	Hela	GSE14283	67618932	67619002	70	0
RARA	MCF7	GSE15244	67623395	67624325	930	0
RARA	MCF7	GSE15244	67640799	67641396	597	0
RARA	MCF7	GSE15244	67642500	67643333	833	0
USF1	HepG2	E	67644308	67644613	305	0
USF2	HepG2	E	67623432	67624325	893	0
hScc1	Bcell	GSE12603	67644510	67645503	993	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-21	hsa-mir-21	17	19082437
hsa-miR-21*	hsa-mir-21	17	19082437

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
4798	mRNA		chr11	67575675	67577804	901	mRNA	CHKA	chr11	67576903	67645434	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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