Annotation Detail for DUSP10

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Basic Information Top

Gene Symbol:	DUSP10 ( MKP-5,MKP5 )
Gene Full Name:	dual specificity phosphatase 10
Band:	1q41
Quick Links	Entrez ID:11221; OMIM: 608867; Uniprot ID:DUS10_HUMAN; ENSEMBL ID: ENSG00000143507; HGNC ID: 3065
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:20 results

Location(AA)	Modification
4	Phosphoserine.

Location(AA)	Modification	Resource
39	O-linked	HMM predict
57	N-linked	HMM predict
79	O-linked	HMM predict
82	O-linked	HMM predict
101	O-linked	HMM predict
102	O-linked	HMM predict
104	O-linked	HMM predict
108	O-linked	HMM predict
109	O-linked	HMM predict
109	O-linked	HMM predict
110	O-linked	HMM predict
128	Phosphoserine(ATM)	HMM predict
128	Phosphoserine(CDC2)	HMM predict
131	O-linked	HMM predict
135	Phosphoserine(CDC2)	HMM predict
140	Phosphothreonine(CDK)	HMM predict
184	N-linked	HMM predict
249	Phosphoserine(ATM)	HMM predict
353	N-linked	HMM predict
378	Phosphoserine(IKK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_144728
Location:chr1 219941388-219977424
strand:-

Upstream the gene:0 results
Downstream the gene:2 results
Inside the gene:7 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
STAT1	HeLa	GSE12782	219930887	219931922	1035	9984
STAT1	HeLa	GSE12783	219931049	219931922	873	9903

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	Jurkat	GSE17954	219947480	219949835	2355	0
FOXA1	MCF7	GSE15244	219955317	219955892	575	0
H3ac	HepG2	E	219956968	219957370	402	0
NRSF	Jurkat	SISSRdata	219953141	219953323	182	0
Nanog	hES	GSE18292	219955281	219956004	723	0
Oct4	hES	GSE21916	219955237	219956043	806	0
TFAP2C	MCF7	GSE21234	219955175	219955978	803	0

Validated miRNA targets

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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