Annotation Detail for EGLN3

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Basic Information Top

Gene Symbol:	EGLN3 ( FLJ21620,HIFPH3,MGC125998,MGC125999,PHD3 )
Gene Full Name:	egl nine homolog 3 (C. elegans)
Band:	14q13.1
Quick Links	Entrez ID:112399; OMIM: 606426; Uniprot ID:EGLN3_HUMAN; ENSEMBL ID: ENSG00000129521; HGNC ID: 14661
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:4 results

No data

Location(AA)	Modification	Resource
128	N-linked	HMM predict
132	Phosphotyrosine(EGFR)	HMM predict
132	Phosphotyrosine(Abl)	HMM predict
227	N-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_022073
Location:chr14 33463173-33490036
strand:-

Upstream the gene:10 results
Downstream the gene:7 results
Inside the gene:15 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Nanog	ES	GSE20650	33498531	33499096	565	8777
Oct1	H2O2-Hela	GSE14283	33491727	33491756	29	1705
Oct1	H2O2-Hela	GSE14283	33500284	33500313	29	10262
Oct1	H2O2-Hela	GSE14283	33500430	33500457	27	10407
Oct1	H2O2-Hela	GSE14283	33502907	33502934	27	12884
Oct1	Hela	GSE14283	33491727	33491756	29	1705
Oct1	Hela	GSE14283	33500283	33500326	43	10268
RNAII	Tamoxifen-MCF7	GSE14664	33500279	33500322	43	10264
TAF	Hela	GSE8489	33491319	33491552	233	1399
USF1	HepG2	E	33493271	33493473	202	3336

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	E2-MCF7	GSE14664	33459120	33459152	32	4038
ER	E2-MCF7	GSE14664	33459229	33459262	33	3928
ER	Fulvestrant-MCF7	GSE14664	33451280	33451312	32	11878
Oct1	H2O2-Hela	GSE14283	33450606	33450636	30	12553
Oct1	Hela	GSE14283	33450605	33450644	39	12549
Oct1	Hela	GSE14283	33458898	33458948	50	4251
STAT1	HeLa	GSE12783	33455790	33457195	1405	6681

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	33489329	33489597	268	0
FOXA1	MCF7	GSE15244	33482076	33482736	660	0
H3K4me3	colorectal	cancer	33488061	33489633	1572	0
HIF1	Hypo	HepG2	33476950	33477784	834	0
Oct1	Hela	GSE14283	33465239	33465269	30	0
PHF8	293T	GSE20725	33489259	33490360	1101	0
PHF8	HeLa	GSE20725	33489160	33490517	1357	0
RARA	MCF7	GSE15244	33482180	33482736	556	0
RARG	MCF7	GSE15244	33476876	33477684	808	0
RARG	MCF7	GSE15244	33482253	33482736	483	0
RARG	MCF7	GSE15244	33488279	33488852	573	0
SRF	k562	GSE8489	33478519	33481263	2744	0
TAF	Hela	GSE8489	33487328	33489286	1958	0
TAF	k562	GSE8489	33487139	33489401	2262	0
hScc1	Bcell	GSE12603	33489329	33490302	973	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-122	hsa-mir-122	18	19296470
hsa-miR-122*	hsa-mir-122	18	19296470

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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