AutismKB 2.0

Annotation Detail for TWF2


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Basic Information Top
Gene Symbol:TWF2 ( A6RP,A6r,PTK9L )
Gene Full Name: twinfilin, actin-binding protein, homolog 2 (Drosophila)
Band: 3p21.2
Quick LinksEntrez ID:11344; OMIM: 607433; Uniprot ID:TWF2_HUMAN; ENSEMBL ID: ENSG00000173366,ENSG00000247596; HGNC ID: 9621
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
14N6-acetyllysine.
19N6-acetyllysine.
309Phosphotyrosine.
349Phosphoserine.
Location(AA) Modifications Resource
309Phosphotyrosine.Swiss-Prot 53.0
309PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
93Phosphoserine(CDK)HMM predict
93PhosphoserineHMM predict
107Phosphothreonine(PKC)HMM predict
167Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_007284
  • Location:chr3 52237666-52248222
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 52247865 52248780 915 100
H3ac HepG2E 52248517 52248780 263 426
H3ac HepG2E 52249140 52250166 1026 1431
Nanog hESGSE18292 52250057 52250320 263 1966
PHF8 HeLaGSE20725 52247493 52249074 1581 61
p130 SenescentGSE19898 52248251 52248705 454 256
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 52236250 52236889 639 1097
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 52240618 52240851 233 0
CTCF CD4SISSRdata 52240618 52240851 233 0
CTCF G2GSE9613 52237418 52238067 649 0
CTCF G2GSE9613 52238922 52239256 334 0
CTCF G2GSE9613 52240450 52241764 1314 0
CTCF G2GSE9613 52242097 52242334 237 0
CTCF G2GSE9613 52243318 52245049 1731 0
CTCF G2GSE9613 52246118 52247403 1285 0
ER MCF7GSE19013 52246537 52247277 740 0
H3K4me2 HCT116GSE10453 52247347 52247935 588 0
H3ac HepG2E 52247134 52247865 731 0
Oct1 HelaGSE14283 52246920 52246988 68 0
Rb GrowingGSE19898 52246568 52246772 204 0
Rb QuiescentGSE19898 52246495 52246803 308 0
Rb SenescentGSE19898 52246650 52246952 302 0
Rb SenescentGSE19898 52247501 52247841 340 0
hScc1 BcellGSE12603 52241040 52241764 724 0
hScc1 G2GSE9613 52243432 52243873 441 0
p130 QuiescentGSE19898 52246607 52246853 246 0
p130 SenescentGSE19898 52246684 52246972 288 0
p130 SenescentGSE19898 52247725 52248021 296 0
p130 shRbQuiescentGSE19898 52247294 52247943 649 0
p130 shRbSenescentGSE19898 52246664 52246824 160 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
18147 mRNA chr3 52248319 52250152 324 EST PTK9L chr3 52241135 52248643 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018