Annotation Detail for CISH

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Basic Information Top

Gene Symbol:	CISH ( CIS,CIS-1,G18,SOCS )
Gene Full Name:	cytokine inducible SH2-containing protein
Band:	3p21.2
Quick Links	Entrez ID:1154; OMIM: 602441; Uniprot ID:CISH_HUMAN; ENSEMBL ID: ENSG00000114737; HGNC ID: 1984
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

No data

Location(AA)	Modification	Resource
50	Phosphothreonine(MAPK)	HMM predict
54	Phosphothreonine(PKC)	HMM predict
75	Phosphoserine(PKC)	HMM predict
142	Phosphoserine(IKK)	HMM predict
173	O-linked	HMM predict
175	Phosphoserine(CDC2)	HMM predict
181	O-linked	HMM predict
193	Phosphoserine(CK1)	HMM predict
218	Phosphoserine(PKC)	HMM predict
218	Phosphoserine(PKA)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_145071
Location:chr3 50618929-50624206
strand:-

Upstream the gene:12 results
Downstream the gene:17 results
Inside the gene:7 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	50624019	50624424	405	15
CTCF	G2	GSE9613	50626318	50627189	871	2547
FOXA1	MCF7	GSE15244	50624612	50625195	583	697
Fos	K562	GSE19551	50624108	50624902	794	299
Gata1	K562	GSE18868	50624374	50624958	584	460
TFAP2C	MCF7	GSE21234	50624390	50624918	528	448
hScc1	Bcell	GSE12603	50623990	50624786	796	182
hScc1	Bcell	GSE12603	50626318	50627261	943	2583
hScc1	CdLS	GSE12603	50626318	50627261	943	2583
hScc1	G2	GSE9613	50626108	50627224	1116	2460
p130	shRbQuiescent	GSE19898	50624493	50624851	358	466
p130	shRbSenescent	GSE19898	50624350	50624864	514	401

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	50612916	50613229	313	5857
CTCF	G2	GSE9613	50613905	50614354	449	4800
ER	MCF7	GSE19013	50617394	50618145	751	1160
FOXA1	MCF7	GSE15244	50612630	50613001	371	6114
FOXA1	MCF7	GSE15244	50614776	50615352	576	3866
FOXA1	MCF7	GSE15244	50617183	50618610	1427	1033
H3ac	HepG2	E	50613905	50614312	407	4821
P300	T0-glioblastoma	GSE21026	50613207	50613886	679	5383
P300	T30-glioblastoma	GSE21026	50614019	50614911	892	4465
RARG	MCF7	GSE15244	50614776	50615624	848	3730
Rb	Growing	GSE19898	50613352	50613518	166	5495
Stat6	IL-4-hr1	GSE17850	50613228	50615176	1948	4728
hScc1	Bcell	GSE12603	50613629	50614024	395	5103
p130	Quiescent	GSE19898	50613553	50614250	697	5028
p130	Senescent	GSE19898	50613613	50613961	348	5143
p130	Senescent	GSE19898	50615007	50615285	278	3784
p130	shRbQuiescent	GSE19898	50613288	50614466	1178	5053

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	50619802	50620227	425
CTCF	G2	GSE9613	50622098	50622681	583
CTCF	G2	GSE9613	50623014	50623599	585
FOXA1	MCF7	GSE15244	50620104	50620634	530
FOXA1	MCF7	GSE15244	50623489	50623852	363
TFAP2C	MCF7	GSE21234	50619479	50620308	829
p130	shRbSenescent	GSE19898	50624040	50624245	205

Validated miRNA targets

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miR Walk:77 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	20486857
hsa-let-7a	hsa-let-7a-2	11	20486857
hsa-let-7a	hsa-let-7a-3	22	20486857
hsa-let-7a	hsa-let-7a-1	9	19592657
hsa-let-7a	hsa-let-7a-2	11	19592657
hsa-let-7a	hsa-let-7a-3	22	19592657
hsa-let-7a*	hsa-let-7a-1	9	20486857
hsa-let-7a*	hsa-let-7a-3	22	20486857
hsa-let-7a*	hsa-let-7a-1	9	19592657
hsa-let-7a*	hsa-let-7a-3	22	19592657
hsa-let-7b	hsa-let-7b	22	20486857
hsa-let-7b	hsa-let-7b	22	19592657
hsa-let-7b*	hsa-let-7b	22	20486857
hsa-let-7b*	hsa-let-7b	22	19592657
hsa-let-7c	hsa-let-7c	21	20486857
hsa-let-7c	hsa-let-7c	21	19592657
hsa-let-7c*	hsa-let-7c	21	20486857
hsa-let-7c*	hsa-let-7c	21	19592657
hsa-let-7d	hsa-let-7d	9	20486857
hsa-let-7d	hsa-let-7d	9	19592657
hsa-let-7d*	hsa-let-7d	9	20486857
hsa-let-7d*	hsa-let-7d	9	19592657
hsa-let-7e	hsa-let-7e	19	20486857
hsa-let-7e	hsa-let-7e	19	19592657
hsa-let-7e*	hsa-let-7e	19	20486857
hsa-let-7e*	hsa-let-7e	19	19592657
hsa-let-7f	hsa-let-7f-1	9	20486857
hsa-let-7f	hsa-let-7f-2	X	20486857
hsa-let-7f	hsa-let-7f-1	9	19592657
hsa-let-7f	hsa-let-7f-2	X	19592657
hsa-let-7f-1*	hsa-let-7f-1	9	20486857
hsa-let-7f-1*	hsa-let-7f-1	9	19592657
hsa-let-7f-2*	hsa-let-7f-2	X	20486857
hsa-let-7f-2*	hsa-let-7f-2	X	19592657
hsa-let-7g	hsa-let-7g	3	20486857
hsa-let-7g	hsa-let-7g	3	19592657
hsa-let-7g*	hsa-let-7g	3	20486857
hsa-let-7g*	hsa-let-7g	3	19592657
hsa-let-7i	hsa-let-7i	12	20486857
hsa-let-7i	hsa-let-7i	12	19592657
hsa-let-7i*	hsa-let-7i	12	20486857
hsa-let-7i*	hsa-let-7i	12	19592657
hsa-miR-146a	hsa-mir-146a	5	20549817
hsa-miR-146a*	hsa-mir-146a	5	20549817
hsa-miR-149	hsa-mir-149	2	20549817
hsa-miR-149*	hsa-mir-149	2	20549817
hsa-miR-155	hsa-mir-155	21	20548288
hsa-miR-155	hsa-mir-155	21	19651781
hsa-miR-155*	hsa-mir-155	21	20548288
hsa-miR-155*	hsa-mir-155	21	19651781
hsa-miR-181a	hsa-mir-181a-2	9	21274007
hsa-miR-181a	hsa-mir-181a-1	1	21274007
hsa-miR-196a	hsa-mir-196a-2	12	20549817
hsa-miR-196a*	hsa-mir-196a-2	12	20549817
hsa-miR-200b	hsa-mir-200b	1	20548288
hsa-miR-200b*	hsa-mir-200b	1	20548288
hsa-miR-29a	hsa-mir-29a	7	21081840
hsa-miR-29a*	hsa-mir-29a	7	21081840
hsa-miR-29b	hsa-mir-29b-1	7	21081840
hsa-miR-29b	hsa-mir-29b-2	1	21081840
hsa-miR-29b-1*	hsa-mir-29b-1	7	21081840
hsa-miR-29b-2*	hsa-mir-29b-2	1	21081840
hsa-miR-29c	hsa-mir-29c	1	21081840
hsa-miR-29c	hsa-mir-29c	1	20548288
hsa-miR-29c*	hsa-mir-29c	1	21081840
hsa-miR-29c*	hsa-mir-29c	1	20548288
hsa-miR-34a	hsa-mir-34a	1	20548288
hsa-miR-34a*	hsa-mir-34a	1	20548288
hsa-miR-374a	hsa-mir-374a	X	21274007
hsa-miR-374a*	hsa-mir-374a	X	21274007
hsa-miR-499-3p	hsa-mir-499	20	20549817
hsa-miR-499-5p	hsa-mir-499	20	20549817
hsa-miR-519a	hsa-mir-519a-1	19	21274007
hsa-miR-519a	hsa-mir-519a-2	19	21274007
hsa-miR-630	hsa-mir-630	15	21274007
hsa-miR-98	hsa-mir-98	X	20486857
hsa-miR-98	hsa-mir-98	X	19592657

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for CISH

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics