AutismKB 2.0

Annotation Detail for CLCN6


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Basic Information Top
Gene Symbol:CLCN6 ( CLC-6,KIAA0046 )
Gene Full Name: chloride channel 6
Band: 1p36.22
Quick LinksEntrez ID:1185; OMIM: 602726; Uniprot ID:CLCN6_HUMAN; ENSEMBL ID: ENSG00000011021; HGNC ID: 2024
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
160Selectivity filter part_1 (By
202Selectivity filter part_2 (By
410N-linked (GlcNAc...).
422N-linked (GlcNAc...).
432N-linked (GlcNAc...).
491Selectivity filter part_3 (By
Location(AA) Modifications Resource
Location(AA) Modification Resource
25Phosphothreonine(MAPK)HMM predict
48Phosphotyrosine(INSR)HMM predict
48Phosphotyrosine(Syk)HMM predict
137N-linkedHMM predict
179Phosphothreonine(PKC)HMM predict
432N-linkedHMM predict
435Phosphotyrosine(Syk)HMM predict
435Phosphotyrosine(SRC)HMM predict
436N-linkedHMM predict
461Phosphoserine(CDC2)HMM predict
483Phosphoserine(ATM)HMM predict
608N-linkedHMM predict
675Phosphoserine(PKG)HMM predict
696Phosphoserine(CK2)HMM predict
761Phosphoserine(IKK)HMM predict
763Phosphoserine(ATM)HMM predict
765Phosphoserine(IKK)HMM predict
766Phosphoserine(IKK)HMM predict
768Phosphoserine(ATM)HMM predict
773Phosphoserine(PKG)HMM predict
781SulfotyrosineHMM predict
784SulfotyrosineHMM predict
806Phosphotyrosine(INSR)HMM predict
806Phosphotyrosine(Syk)HMM predict
808N-linkedHMM predict
810O-linkedHMM predict
852N-linkedHMM predict
869IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001286
  • Location:chr1 11788880-11825771
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
HIF1 NormHepG2 11788368 11789214 846 90
p130 SenescentGSE19898 11788590 11789038 448 67
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF mAbJurkat 11826111 11827708 1597 1138
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 11821373 11821714 341 0
CTCF CD4SISSRdata 11821373 11821714 341 0
CTCF HelaGSE12889 11821334 11821585 251 0
CTCF JurkatGSE12889 11821280 11821615 335 0
CTCF G2GSE9613 11819976 11820261 285 0
CTCF G2GSE9613 11820878 11821563 685 0
H3ac HepG2E 11789027 11790345 1318 0
H3ac HepG2E 11812219 11812437 218 0
H3ac HepG2E 11823139 11823925 786 0
Myc K562GSE19551 11824674 11825608 934 0
NRSF mAbJurkat 11822206 11825765 3559 0
Rb SenescentGSE19898 11821421 11821606 185 0
Rb shRbSenescenceGSE19898 11821300 11821558 258 0
TAFII hESGSE17917 11821391 11821710 319 0
USF1 HepG2E 11824589 11825655 1066 0
USF2 HepG2E 11824698 11825765 1067 0
hScc1 BcellGSE12603 11820878 11821844 966 0
hScc1 CdLSGSE12603 11805446 11805618 172 0
hScc1 CdLSGSE12603 11821035 11821870 835 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
202 mRNA CLCN6 chr1 11800559 11837451 113 mRNA MTHFR chr1 11797350 11801243Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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