AutismKB 2.0

Annotation Detail for CLU


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Basic Information Top
Gene Symbol:CLU ( APOJ,CLI,KUB1,MGC24903,SGP-2,SGP2,SP-40,TRPM-2,TRPM2 )
Gene Full Name: clusterin
Band: 8p21.1
Quick LinksEntrez ID:1191; OMIM: 185430; Uniprot ID:CLUS_HUMAN; ENSEMBL ID: ENSG00000120885; HGNC ID: 2095
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
81Nuclear localization signal (By
86N-linked (GlcNAc...).
103N-linked (GlcNAc...).
145N-linked (GlcNAc...).
291N-linked (GlcNAc...).
317N-linked (GlcNAc...).
354N-linked (GlcNAc...).
374N-linked (GlcNAc...) (complex).
393Phosphothreonine.
394Phosphoserine.
396Phosphoserine.
447Nuclear localization signal (By
Location(AA) Modifications Resource
86N-linked (GlcNAc...).Swiss-Prot 53.0
103N-linked (GlcNAc...).Swiss-Prot 53.0
145N-linked (GlcNAc...).Swiss-Prot 53.0
291N-linked (GlcNAc...).Swiss-Prot 53.0
354N-linked (GlcNAc...).Swiss-Prot 53.0
374N-linked (GlcNAc...).Swiss-Prot 53.0
Location(AA) Modification Resource
27Phosphoserine(CK2)HMM predict
86N-linkedHMM predict
103N-linkedHMM predict
145N-linkedHMM predict
161Phosphoserine(CK1)HMM predict
185Phosphoserine(PKB)HMM predict
233Phosphoserine(ATM)HMM predict
233Phosphoserine(CDC2)HMM predict
235Phosphotyrosine(Syk)HMM predict
291N-linkedHMM predict
317N-linkedHMM predict
357Phosphoserine(CK1)HMM predict
374N-linkedHMM predict
383Phosphotyrosine(EGFR)HMM predict
383Phosphotyrosine(Syk)HMM predict
387O-linkedHMM predict
418O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001831
  • Location:chr8 27510368-27528243
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 27528318 27528990 672 411
FOXA1 MCF7GSE15244 27530648 27530852 204 2507
RARA MCF7GSE15244 27530648 27530852 204 2507
RARG MCF7GSE15244 27530648 27530852 204 2507
TFAP2C MCF7GSE21234 27530301 27530860 559 2337
hScc1 BcellGSE12603 27528069 27528638 569 110
hScc1 CdLSGSE12603 27528187 27528569 382 135
hScc1 G2GSE9613 27527600 27529036 1436 75
p130 shRbQuiescentGSE19898 27530436 27531157 721 2553
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 27524994 27525541 547 0
CTCF G2GSE9613 27527878 27528569 691 0
FOXA1 MCF7GSE15244 27527495 27527878 383 0
PolII HeLaGSE12783 27527285 27528665 1380 0
RARA MCF7GSE15244 27527495 27527878 383 0
RARG MCF7GSE15244 27527495 27527847 352 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125b hsa-mir-125b-1 11 18056640
hsa-miR-125b hsa-mir-125b-2 21 18056640
hsa-miR-125b hsa-mir-125b-1 11 18056640
hsa-miR-125b hsa-mir-125b-2 21 18056640
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25217 HTC chr8 27506884 27510992 480 mRNA CLU chr8 27510367 27528244Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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