AutismKB 2.0

Annotation Detail for TPH2


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Basic Information Top
Gene Symbol:TPH2 ( ADHD7,FLJ37295,MGC138871,MGC138872,NTPH )
Gene Full Name: tryptophan hydroxylase 2
Band: 12q21.1
Quick LinksEntrez ID:121278; OMIM: 607478; Uniprot ID:TPH2_HUMAN; ENSEMBL ID: ENSG00000139287; HGNC ID: 20692
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
382Phosphoserine.
392Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
19Phosphoserine(PKB)HMM predict
103Phosphoserine(PKA)HMM predict
103Phosphoserine(CK1)HMM predict
103Phosphoserine(PKG)HMM predict
104Phosphoserine(PKG)HMM predict
104Phosphoserine(PKA)HMM predict
104Phosphoserine(PKB)HMM predict
143Phosphothreonine(CK2)HMM predict
159Phosphoserine(PKG)HMM predict
193Phosphotyrosine(Jak)HMM predict
212SulfotyrosineHMM predict
310SulfotyrosineHMM predict
311Phosphothreonine(MAPK)HMM predict
311Phosphothreonine(CDK)HMM predict
336Phosphoserine(ATM)HMM predict
419Phosphotyrosine(Jak)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_173353
  • Location:chr12 70618892-70712487
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF JurkatGSE13047 70618352 70619395 1043 19
NRSF mAbJurkat 70617276 70618195 919 1157
NRSF-mono JurkatQuESTdata 70618362 70619394 1032 15
NRSF pAbJurkat 70617276 70618195 919 1157
NRSF pAbJurkat 70618511 70619256 745 9
hScc1 BcellGSE12603 70618552 70619221 669 6
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 70618916 70619054 138 0
CTCF CD4GSE12889 70697126 70697443 317 0
CTCF CD4SISSRdata 70618916 70619054 138 0
CTCF CD4SISSRdata 70697126 70697443 317 0
CTCF G2GSE9613 70618552 70619293 741 0
CTCF G2GSE9613 70697137 70697413 276 0
ER Fulvestrant-MCF7GSE14664 70655456 70655497 41 0
ER Fulvestrant-MCF7GSE14664 70658776 70658809 33 0
ER Fulvestrant-MCF7GSE14664 70703577 70703611 34 0
ETS1 JurkatGSE17954 70618576 70619330 754 0
FOXA1 MCF7GSE15244 70618903 70619221 318 0
Myc K562GSE19551 70618741 70619117 376 0
Myc K562GSE19551 70697211 70697429 218 0
NRSF mAbJurkat 70618511 70623767 5256 0
NRSF mAbJurkat 70660700 70661873 1173 0
NRSF-mono JurkatQuESTdata 70661230 70661485 255 0
NRSF-poly JurkatQuESTdata 70618580 70619305 725 0
Oct1 H2O2-HelaGSE14283 70632583 70632611 28 0
Oct1 H2O2-HelaGSE14283 70655458 70655496 38 0
Oct1 H2O2-HelaGSE14283 70665079 70665110 31 0
Oct1 H2O2-HelaGSE14283 70671472 70671508 36 0
Oct1 HelaGSE14283 70622784 70622816 32 0
Oct1 HelaGSE14283 70632539 70632611 72 0
Oct1 HelaGSE14283 70655446 70655519 73 0
Oct1 HelaGSE14283 70658772 70658827 55 0
Oct1 HelaGSE14283 70671470 70671508 38 0
Oct1 HelaGSE14283 70703582 70703613 31 0
Oct4 hESGSE17917 70697179 70697511 332 0
RNAII Tamoxifen-MCF7GSE14664 70703573 70703613 40 0
Rb shRbQuiescentGSE19898 70669340 70669570 230 0
STAT1 IFNSISSRdata 70618741 70619223 482 0
hScc1 BcellGSE12603 70697137 70697612 475 0
hScc1 CdLSGSE12603 70618552 70619256 704 0
hScc1 CdLSGSE12603 70697068 70697612 544 0
hScc1 G2GSE9613 70618552 70619293 741 0
hScc1 G2GSE9613 70697068 70697450 382 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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