AutismKB 2.0

Annotation Detail for FGD4


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Basic Information Top
Gene Symbol:FGD4 ( CMT4H,DKFZp313E1818,DKFZp434K1572,FLJ34370,FLJ42663,FRABP,MGC57222,ZFYVE6 )
Gene Full Name: FYVE, RhoGEF and PH domain containing 4
Band: 12p11.21
Quick LinksEntrez ID:121512; OMIM: 611104; Uniprot ID:FGD4_HUMAN; ENSEMBL ID: ENSG00000139132; HGNC ID: 19125
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
702Phosphoserine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
10Phosphoserine(IKK)HMM predict
36Phosphotyrosine(INSR)HMM predict
52Phosphothreonine(CDC2)HMM predict
52Phosphothreonine(CDK)HMM predict
52Phosphothreonine(MAPK)HMM predict
61Phosphothreonine(CDC2)HMM predict
61Phosphothreonine(CDK)HMM predict
68Phosphoserine(ATM)HMM predict
77N-linkedHMM predict
115Phosphoserine(IKK)HMM predict
137O-linkedHMM predict
141O-linkedHMM predict
141O-linkedHMM predict
141Phosphoserine(IKK)HMM predict
143O-linkedHMM predict
146Phosphoserine(IKK)HMM predict
150N-linkedHMM predict
281Phosphothreonine(PKC)HMM predict
315N-linkedHMM predict
317Phosphothreonine(PKC)HMM predict
418N-linkedHMM predict
421N-linkedHMM predict
436N-linkedHMM predict
466Phosphothreonine(PKC)HMM predict
622Phosphothreonine(CK2)HMM predict
652Phosphotyrosine(INSR)HMM predict
758ProlineHMM predict
766S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_139241
  • Location:chr12 32546360-32684939
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 32538901 32539080 179 7370
ER E2-MCF7GSE14664 32534835 32534876 41 11505
ER E2-MCF7GSE14664 32535826 32535911 85 10492
ER E2-MCF7GSE14664 32536067 32536105 38 10275
ER Fulvestrant-MCF7GSE14664 32529189 32529231 42 17151
ER Fulvestrant-MCF7GSE14664 32535825 32535889 64 10504
Oct1 H2O2-HelaGSE14283 32529781 32529823 42 16559
Oct1 HelaGSE14283 32529781 32529824 43 16558
Oct1 HelaGSE14283 32540301 32540329 28 6046
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 32701769 32702168 399 17029
Oct1 HelaGSE14283 32690509 32690544 35 5587
hScc1 BcellGSE12603 32701837 32702132 295 17045
hScc1 CdLSGSE12603 32701804 32702200 396 17063
hScc1 CdLSGSE12603 32703537 32703781 244 18720
hScc1 G2GSE9613 32701837 32702200 363 17079
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 32578220 32578607 387 0
H3ac HepG2E 32581425 32581829 404 0
H3ac HepG2E 32585875 32586584 709 0
NRSF JurkatSISSRdata 32604245 32604381 136 0
Nanog hESGSE18292 32603935 32604372 437 0
Oct1 H2O2-HelaGSE14283 32648546 32648581 35 0
Oct1 HelaGSE14283 32600116 32600148 32 0
Oct1 HelaGSE14283 32611773 32611803 30 0
P300 T30-glioblastomaGSE21026 32612411 32612780 369 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018