AutismKB 2.0

Annotation Detail for LEO1


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Basic Information Top
Gene Symbol:LEO1 ( RDL )
Gene Full Name: Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 15q21.2
Quick LinksEntrez ID:123169; OMIM: 610507; Uniprot ID:LEO1_HUMAN; ENSEMBL ID: ENSG00000166477; HGNC ID: 30401
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
10Phosphoserine.
14Phosphoserine.
151Phosphoserine.
154Phosphoserine.
162Phosphoserine.
171Phosphoserine.
179Phosphoserine.
188Phosphothreonine.
197Phosphoserine.
205Phosphoserine.
212Phosphoserine.
220Phosphoserine.
229Phosphoserine.
238Phosphoserine.
246Phosphoserine (By similarity).
254Phosphoserine (By similarity).
271Phosphoserine.
277Phosphoserine.
279Phosphoserine.
294Phosphoserine.
296Phosphoserine.
300Phosphoserine.
302Phosphothreonine.
551Phosphoserine.
607Phosphoserine.
608Phosphoserine.
610Phosphoserine.
614Phosphoserine.
629Phosphothreonine.
630Phosphoserine.
658Phosphoserine.
Location(AA) Modifications Resource
10Phosphoserine.Swiss-Prot 53.0
10PhosphoserinePhospho.ELM 6.0
14Phosphoserine.Swiss-Prot 53.0
14PhosphoserinePhospho.ELM 6.0
29PhosphoserinePhospho.ELM 6.0
151Phosphoserine.Swiss-Prot 53.0
151PhosphoserinePhospho.ELM 6.0
154PhosphoserinePhospho.ELM 6.0
154Phosphoserine.Swiss-Prot 53.0
162PhosphoserinePhospho.ELM 6.0
162Phosphoserine.Swiss-Prot 53.0
171Phosphoserine.Swiss-Prot 53.0
171PhosphoserinePhospho.ELM 6.0
179Phosphoserine.Swiss-Prot 53.0
188Phosphothreonine.Swiss-Prot 53.0
188PhosphothreoninePhospho.ELM 6.0
197Phosphoserine.Swiss-Prot 53.0
197PhosphoserinePhospho.ELM 6.0
205PhosphoserinePhospho.ELM 6.0
205Phosphoserine.Swiss-Prot 53.0
212PhosphoserinePhospho.ELM 6.0
212Phosphoserine.Swiss-Prot 53.0
220Phosphoserine.Swiss-Prot 53.0
220PhosphoserinePhospho.ELM 6.0
229PhosphoserinePhospho.ELM 6.0
229Phosphoserine.Swiss-Prot 53.0
238Phosphoserine.Swiss-Prot 53.0
238PhosphoserinePhospho.ELM 6.0
271Phosphoserine.Swiss-Prot 53.0
277PhosphoserinePhospho.ELM 6.0
277Phosphoserine.Swiss-Prot 53.0
279Phosphoserine.Swiss-Prot 53.0
279PhosphoserinePhospho.ELM 6.0
294PhosphoserinePhospho.ELM 6.0
294Phosphoserine.Swiss-Prot 53.0
296PhosphoserinePhospho.ELM 6.0
300PhosphoserinePhospho.ELM 6.0
300Phosphoserine.Swiss-Prot 53.0
302PhosphothreoninePhospho.ELM 6.0
302Phosphothreonine.Swiss-Prot 53.0
551Phosphoserine.Swiss-Prot 53.0
551PhosphoserinePhospho.ELM 6.0
629Phosphothreonine.Swiss-Prot 53.0
629PhosphothreoninePhospho.ELM 6.0
630PhosphoserinePhospho.ELM 6.0
630Phosphoserine.Swiss-Prot 53.0
658Phosphoserine.Swiss-Prot 53.0
658PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
10Phosphoserine(CK2)HMM predict
14Phosphoserine(CK2)HMM predict
21Phosphoserine(CK1)HMM predict
21Phosphoserine(PKA)HMM predict
21Phosphoserine(PKG)HMM predict
23Phosphoserine(CK1)HMM predict
23Phosphoserine(IKK)HMM predict
25Phosphoserine(CK1)HMM predict
27Phosphoserine(CK2)HMM predict
29Phosphoserine(CK1)HMM predict
29Phosphoserine(ATM)HMM predict
38Phosphoserine(IKK)HMM predict
39N-linkedHMM predict
45Phosphoserine(CK2)HMM predict
45Phosphoserine(ATM)HMM predict
66PhosphoserineHMM predict
77Phosphoserine(CK1)HMM predict
79N-linkedHMM predict
84Phosphoserine(CK1)HMM predict
86N-linkedHMM predict
91Phosphoserine(CK2)HMM predict
94Phosphoserine(CK1)HMM predict
94Phosphoserine(CK2)HMM predict
140Phosphoserine(CK2)HMM predict
140Phosphoserine(CK2)HMM predict
154Phosphoserine(CK2)HMM predict
162Phosphoserine(CK2)HMM predict
179PhosphoserineHMM predict
179Phosphoserine(CK2)HMM predict
179Phosphoserine(CK2)HMM predict
188Phosphothreonine(CK2)HMM predict
197Phosphoserine(CK2)HMM predict
212Phosphoserine(CK2)HMM predict
229Phosphoserine(CK2)HMM predict
229Phosphoserine(CK2)HMM predict
238Phosphoserine(CK2)HMM predict
254Phosphoserine(CK2)HMM predict
261Phosphoserine(CK2)HMM predict
261Phosphoserine(CK1)HMM predict
277Phosphoserine(CK2)HMM predict
279Phosphoserine(CK2)HMM predict
279PhosphoserineHMM predict
296Phosphoserine(IKK)HMM predict
296Phosphoserine(CK2)HMM predict
300Phosphoserine(CK1)HMM predict
323Phosphoserine(CK1)HMM predict
325Phosphoserine(CK2)HMM predict
333Phosphothreonine(MAPK)HMM predict
333Phosphothreonine(CDC2)HMM predict
333Phosphothreonine(CDK)HMM predict
393SulfotyrosineHMM predict
394Phosphotyrosine(EGFR)HMM predict
394Phosphotyrosine(Syk)HMM predict
495Phosphoserine(IKK)HMM predict
496O-linkedHMM predict
505Phosphothreonine(PKA)HMM predict
551Phosphoserine(PKG)HMM predict
575Phosphotyrosine(Syk)HMM predict
575Phosphotyrosine(EGFR)HMM predict
575Phosphotyrosine(SRC)HMM predict
575Phosphotyrosine(INSR)HMM predict
608Phosphoserine(CK2)HMM predict
610Phosphoserine(CK1)HMM predict
614Phosphoserine(CK1)HMM predict
629Phosphothreonine(CK2)HMM predict
629Phosphothreonine(PKC)HMM predict
630Phosphoserine(CK1)HMM predict
657IsoleucineHMM predict
658Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_138792
  • Location:chr15 50017516-50051249
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 50061705 50062163 458 10685
CTCF CD4SISSRdata 50061705 50062163 458 10685
FoxA1 MCF7MACSdata 50070719 50070955 236 19588
STAT1 HeLaGSE12783 50054898 50055883 985 4141
STAT1 IFNSISSRdata 50054911 50055717 806 4065
TAF HelaGSE8489 50061057 50061859 802 10209
TAFII hESGSE17917 50050914 50051647 733 31
TFAP2C MCF7GSE21234 50070462 50071075 613 19519
hScc1 BcellGSE12603 50061287 50061929 642 10359
hScc1 CdLSGSE12603 50061411 50062064 653 10488
p130 SenescentGSE19898 50051235 50051574 339 155
p130 shRbSenescentGSE19898 50051309 50051582 273 196
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 50011230 50011524 294 6140
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 50050284 50051736 1452 0
FOXA1 MCF7GSE15244 50050472 50051587 1115 0
FOXA1 eGFPGSE10845 50050472 50051587 1115 0
Fos K562GSE19551 50050885 50051613 728 0
FoxA1 MCF7MACSdata 50049868 50049968 100 0
H3K4me2 HCT116GSE10453 50050472 50050859 387 0
H3K4me3 colorectalcancer 50050472 50050830 358 0
H3ac HepG2E 50050472 50051316 844 0
Oct1 HelaGSE14283 50039298 50039333 35 0
P300 T30-glioblastomaGSE21026 50050614 50051598 984 0
PHF8 293TGSE20725 50050713 50051523 810 0
PHF8 HeLaGSE20725 50050550 50051814 1264 0
TAF HelaGSE8489 50050472 50051548 1076 0
hScc1 BcellGSE12603 50029581 50029865 284 0
hScc1 BcellGSE12603 50050830 50051510 680 0
p130 QuiescentGSE19898 50050938 50051382 444 0
p130 shRbQuiescentGSE19898 50050725 50051443 718 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8829 EST chr15 50010540 50026784 9271 mRNA LOC123169 chr15 50017513 50051250 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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