AutismKB 2.0

Annotation Detail for HIST2H3C


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Basic Information Top
Gene Symbol:HIST2H3C ( H3,H3.2,H3/M,H3F2,H3FM,H3FN,HIST2H3A,HIST2H3D,MGC9629 )
Gene Full Name: histone cluster 2, H3c
Band: 1q21.2
Quick LinksEntrez ID:126961; OMIM: 142780; Uniprot ID:H32_HUMAN; ENSEMBL ID: ENSG00000203811; HGNC ID: 20503
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
3Asymmetric dimethylarginine; by PRMT6.
4Phosphothreonine.
5N6-acetyllysine; alternate.
5N6-methyllysine; alternate.
7Phosphothreonine; by PKC.
9Symmetric dimethylarginine; by PRMT5;
9Citrulline; alternate.
10N6,N6,N6-trimethyllysine; alternate.
10N6,N6-dimethyllysine; alternate.
10N6-acetyllysine; alternate.
10N6-methyllysine; alternate.
11Phosphoserine.
12Phosphothreonine; by PKC.
15N6-acetyllysine.
18Citrulline; alternate.
18Asymmetric dimethylarginine; by CARM1;
19N6-acetyllysine; alternate.
19N6-methyllysine; alternate.
24N6-acetyllysine; alternate.
24N6-methyllysine; alternate.
28N6,N6,N6-trimethyllysine; alternate.
28N6,N6-dimethyllysine; alternate.
28N6-acetyllysine; alternate.
28N6-methyllysine; alternate.
29Phosphoserine.
37N6,N6,N6-trimethyllysine; alternate.
37N6,N6-dimethyllysine; alternate.
37N6-acetyllysine; alternate.
37N6-methyllysine; alternate.
42Phosphotyrosine.
57N6,N6,N6-trimethyllysine; alternate.
57N6-acetyllysine; alternate.
57N6-methyllysine; alternate.
58Phosphoserine.
65N6-methyllysine.
80N6-methyllysine; alternate.
80N6,N6,N6-trimethyllysine; alternate (By
80N6,N6-dimethyllysine; alternate.
80N6-acetyllysine; alternate.
81Phosphothreonine.
123N6-methyllysine.
Location(AA) Modifications Resource
4Phosphothreonine.Swiss-Prot 53.0
5N6-acetyllysine; alternate.Swiss-Prot 53.0
5N6-methyllysine; alternate.Swiss-Prot 53.0
9Citrulline; alternate.Swiss-Prot 53.0
9Symmetric dimethylarginine; by PRMT5;alternate (By similarity).Swiss-Prot 53.0
10N6-methyllysine; alternate.Swiss-Prot 53.0
10N6-acetyllysine; alternate.Swiss-Prot 53.0
10N6,N6-dimethyllysine; alternate.Swiss-Prot 53.0
10N6,N6,N6-trimethyllysine; alternate.Swiss-Prot 53.0
11Phosphoserine.Swiss-Prot 53.0
12Phosphothreonine.Swiss-Prot 53.0
15N6-acetyllysine.Swiss-Prot 53.0
18Asymmetric dimethylarginine; by CARM1;alternate.Swiss-Prot 53.0
18Citrulline; alternate.Swiss-Prot 53.0
19N6-acetyllysine; alternate.Swiss-Prot 53.0
19N6-methyllysine; alternate.Swiss-Prot 53.0
24N6-acetyllysine; alternate.Swiss-Prot 53.0
24N6-methyllysine; alternate.Swiss-Prot 53.0
28N6-methyllysine; alternate.Swiss-Prot 53.0
28N6-acetyllysine; alternate.Swiss-Prot 53.0
28N6,N6-dimethyllysine; alternate.Swiss-Prot 53.0
28N6,N6,N6-trimethyllysine; alternate.Swiss-Prot 53.0
29Phosphoserine.Swiss-Prot 53.0
37N6,N6,N6-trimethyllysine; alternate.Swiss-Prot 53.0
37N6,N6-dimethyllysine; alternate.Swiss-Prot 53.0
37N6-acetyllysine; alternate.Swiss-Prot 53.0
37N6-methyllysine; alternate.Swiss-Prot 53.0
57N6-methyllysine; alternate.Swiss-Prot 53.0
57N6-acetyllysine; alternate.Swiss-Prot 53.0
57N6,N6,N6-trimethyllysine; alternate.Swiss-Prot 53.0
65N6-methyllysine.Swiss-Prot 53.0
80N6,N6,N6-trimethyllysine; alternate (Bysimilarity).Swiss-Prot 53.0
80N6,N6-dimethyllysine; alternate.Swiss-Prot 53.0
80N6-acetyllysine; alternate.Swiss-Prot 53.0
80N6-methyllysine; alternate.Swiss-Prot 53.0
123N6-methyllysine.Swiss-Prot 53.0
Location(AA) Modification Resource
7Phosphothreonine(PKC)HMM predict
12Phosphothreonine(PKC)HMM predict
28MethyllysineHMM predict
119Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_021059
  • Location:chr1 148090804-148091309
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
LIN9 G0GSE7516 148078103 148081661 3558 494
hScc1 CdLSGSE12603 148079530 148080096 566 425
p130 SGSE7516 148088341 148092471 4130 399
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 148078239 148079195 956 166
CTCF G2GSE9613 148090812 148091814 1002 4
H3K4me2 HCT116GSE10453 148077471 148078274 803 1010
H3K4me2 HCT116GSE10453 148091844 148092383 539 804
H3ac HepG2E 148075537 148075889 352 3170
H3ac HepG2E 148076281 148076734 453 2375
H3ac HepG2E 148077124 148078389 1265 1126
H3ac HepG2E 148091844 148093053 1209 1139
H3ac HepG2E 148093450 148093882 432 2357
H3ac HepG2E 148094294 148094630 336 3153
RARA MCF7GSE15244 148075537 148075889 352 3170
RARA MCF7GSE15244 148076281 148076734 453 2375
RARA MCF7GSE15244 148077124 148078389 1265 1126
RARA MCF7GSE15244 148091923 148092444 521 874
RARG MCF7GSE15244 148077150 148078419 1269 1098
RARG MCF7GSE15244 148091785 148092444 659 805
TAF HelaGSE8489 148077150 148078274 1124 1171
TAF k562GSE8489 148075537 148075889 352 3170
TAF k562GSE8489 148077124 148078389 1265 1126
TAF k562GSE8489 148091814 148093053 1239 1124
TAF k562GSE8489 148094294 148094630 336 3153
TFAP2C MCF7GSE21234 148076315 148077044 729 2203
USF2 HepG2E 148077546 148078274 728 973
hScc1 BcellGSE12603 148078203 148078798 595 382
hScc1 BcellGSE12603 148090925 148091993 1068 150
p130 SGSE7516 148077471 148078389 918 953
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 SGSE7516 148078760 148079959 1199 0
E2F4 SGSE7516 148090245 148091408 1163 0
LIN54 G0GSE7516 148078516 148080040 1524 0
LIN54 G0GSE7516 148090325 148091360 1035 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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