Annotation Detail for AADAC

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Basic Information Top

Gene Symbol:	AADAC ( CES5A1,DAC )
Gene Full Name:	arylacetamide deacetylase (esterase)
Band:	3q25.1
Quick Links	Entrez ID:13; OMIM: 600338; Uniprot ID:AAAD_HUMAN; ENSEMBL ID: ENSG00000114771; HGNC ID: 17
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:9 results

Location(AA)	Modification
78	N-linked (GlcNAc...).
282	N-linked (GlcNAc...).

Location(AA)	Modification	Resource
20	Sulfotyrosine	HMM predict
78	N-linked	HMM predict
161	Phosphotyrosine(EGFR)	HMM predict
255	Phosphothreonine(PKC)	HMM predict
297	Phosphotyrosine(INSR)	HMM predict
297	Phosphotyrosine(Abl)	HMM predict
302	Phosphotyrosine(EGFR)	HMM predict
302	Phosphotyrosine(INSR)	HMM predict
387	Leucine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001086
Location:chr3 153014550-153028966
strand:+

Upstream the gene:2 results
Downstream the gene:5 results
Inside the gene:2 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
RARG	MCF7	GSE15244	153012779	153013068	289	1627
hScc1	Bcell	GSE12603	153012779	153013035	256	1644

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	153039453	153039776	323	10648
Myc	K562	GSE19551	153037590	153037877	287	8767
RARA	MCF7	GSE15244	153037364	153037944	580	8688
hScc1	G2	GSE9613	153039418	153039776	358	10631
p63	keratinocytes	GSE17611	153037293	153038252	959	8806

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	MCF7	GSE15244	153016644	153017040	396	0
Rb	Senescent	GSE19898	153016577	153016740	163	0

Validated miRNA targets

miR Walk:4 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-34b	hsa-mir-34b	11	18519671
hsa-miR-34b*	hsa-mir-34b	11	18519671
hsa-miR-34c-3p	hsa-mir-34c	11	18519671
hsa-miR-34c-5p	hsa-mir-34c	11	18519671

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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