Annotation Detail for COMT

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Basic Information Top

Gene Symbol:	COMT ( - )
Gene Full Name:	catechol-O-methyltransferase
Band:	22q11.21
Quick Links	Entrez ID:1312; OMIM: 116790; Uniprot ID:COMT_HUMAN; ENSEMBL ID: ENSG00000093010; HGNC ID: 2228
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
267	Phosphoserine (By similarity).

Location(AA)	Modifications	Resource
267	Phosphoserine (By similarity).	Swiss-Prot 53.0

Location(AA)	Modification	Resource
34	S-palmitoyl	HMM predict
262	Phosphotyrosine(Syk)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	18315340	18315554	214
CTCF	CD4	GSE12889	18321276	18321452	176
CTCF	CD4	GSE12889	18329878	18330038	160
CTCF	CD4	SISSRdata	18315340	18315554	214
CTCF	CD4	SISSRdata	18321276	18321452	176
CTCF	CD4	SISSRdata	18329878	18330038	160
CTCF	Jurkat	GSE12889	18315314	18315561	247
CTCF	Jurkat	GSE12889	18321248	18321513	265
CTCF	Jurkat	GSE12889	18329791	18330069	278
CTCF	G2	GSE9613	18321119	18321866	747
CTCF	G2	GSE9613	18324967	18325316	349
CTCF	G2	GSE9613	18329679	18330288	609
H3ac	HepG2	E	18309511	18310178	667
Myc	K562	GSE19551	18314891	18315591	700
Myc	K562	GSE19551	18321177	18321549	372
PHF8	HeLa	GSE20725	18308914	18309988	1074
Rb	Growing	GSE19898	18309277	18309391	114
TAF	k562	GSE8489	18309626	18310178	552
TFAP2C	MCF7	GSE21234	18326760	18327596	836
USF1	HepG2	E	18318914	18319121	207
p63	keratinocytes	GSE17611	18322849	18323576	727

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
17149	mRNA	COMT	chr22	18303862	18331084	112	mRNA	TXNRD2	chr22	18237599	18304069	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018