Annotation Detail for MAP3K8

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Basic Information Top

Gene Symbol:	MAP3K8 ( COT,EST,ESTF,FLJ10486,MEKK8,TPL2,Tpl-2,c-COT )
Gene Full Name:	mitogen-activated protein kinase kinase kinase 8
Band:	10p11.23
Quick Links	Entrez ID:1326; OMIM: 191195; Uniprot ID:M3K8_HUMAN; ENSEMBL ID: ENSG00000107968; HGNC ID: 6860
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
141	Phosphoserine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	30742907	30743290	383	19773
CTCF	CD4	SISSRdata	30742907	30743290	383	19773
H3ac	HepG2	E	30760214	30761138	924	2196
H3ac	HepG2	E	30761791	30762776	985	588
Myc	K562	GSE19551	30742993	30743349	356	19701
NFkBII	GM12878	GSE19485	30755866	30757555	1689	6161
NFkBII	GM12892	GSE19485	30761464	30764249	2785	15
P300	T30-glioblastoma	GSE21026	30752039	30753577	1538	10064
PolII	HeLa	GSE12783	30751796	30753009	1213	10469
PolII	HeLa	GSE12783	30759446	30764615	5169	841
RARG	MCF7	GSE15244	30752220	30752582	362	10471
Rb	Growing	GSE19898	30762058	30762213	155	736
Rb	Growing	GSE19898	30762272	30762476	204	498
Rb	Quiescent	GSE19898	30762091	30762254	163	699
TFAP2C	MCF7	GSE21234	30762448	30763103	655	96
hScc1	Bcell	GSE12603	30742996	30743174	178	19787
hScc1	CdLS	GSE12603	30742996	30743174	178	19787
p130	Quiescent	GSE19898	30752337	30752594	257	10406
p130	Quiescent	GSE19898	30762713	30762953	240	39
p130	Senescent	GSE19898	30762673	30762882	209	94

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	Hela	GSE14283	30802282	30802310	28	11530

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
Gata2	K562	GSE18868	30765686	30766740	1054
H3K4me3	colorectal	cancer	30763758	30764432	674
H3K4me3	colorectal	cancer	30764811	30765330	519
H3ac	HepG2	E	30763657	30764432	775
H3ac	HepG2	E	30764811	30766053	1242
H3ac	HepG2	E	30766497	30767312	815
NFkBII	GM10847	GSE19485	30761785	30764328	2543
NFkBII	GM15510	GSE19485	30761823	30764639	2816
NFkBII	GM18505	GSE19485	30761704	30764615	2911
NFkBII	GM18526	GSE19485	30761572	30764246	2674
RARA	MCF7	GSE15244	30775985	30776603	618
RARG	MCF7	GSE15244	30763758	30764202	444
RARG	MCF7	GSE15244	30775985	30776603	618
TAF	k562	GSE8489	30763657	30764432	775
TAF	k562	GSE8489	30764811	30766053	1242
hScc1	Bcell	GSE12603	30762196	30764057	1861
hScc1	CdLS	GSE12603	30761791	30764392	2601
p130	Quiescent	GSE19898	30763380	30763602	222

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7c	hsa-let-7c	21	18006822
hsa-let-7c*	hsa-let-7c	21	18006822
hsa-miR-10a	hsa-mir-10a	17	18006822
hsa-miR-10a*	hsa-mir-10a	17	18006822
hsa-miR-144	hsa-mir-144	17	18006822
hsa-miR-144*	hsa-mir-144	17	18006822
hsa-miR-150	hsa-mir-150	19	18006822
hsa-miR-150*	hsa-mir-150	19	18006822
hsa-miR-155	hsa-mir-155	21	18006822
hsa-miR-155*	hsa-mir-155	21	18006822
hsa-miR-370	hsa-mir-370	14	17621267

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
617	Unknown	TRUE	miR-370	MAP3K8	n_a	17621267
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000107968		n_a	n_a	n_a	"epithelium, squamous cell, lymphocyte, leukocyte"	"benign tumour, malignant tumour, carcinoma, leukaemia"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018