AutismKB 2.0

Annotation Detail for ATF2


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Basic Information Top
Gene Symbol:ATF2 ( CRE-BP1,CREB2,HB16,MGC111558,TREB7 )
Gene Full Name: activating transcription factor 2
Band: 2q31.1
Quick LinksEntrez ID:1386; OMIM: 123811; Uniprot ID:ATF2_HUMAN; ENSEMBL ID: ENSG00000115966; HGNC ID: 784
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
69Phosphothreonine; by MAPK14.
71Phosphothreonine; by MAPK14.
90Phosphoserine.
112Phosphoserine.
328Phosphoserine.
Location(AA) Modifications Resource
44Phosphoserine (PKA
51Phosphothreonine (by MAPK14).Swiss-Prot 53.0
51Phosphothreonine (MAPK14;MAPK8)Phospho.ELM 6.0
53Phosphothreonine (MAPK14;MAPK8)Phospho.ELM 6.0
53Phosphothreonine (by MAPK14).Swiss-Prot 53.0
55Phosphothreonine (VRK1)Phospho.ELM 6.0
94PhosphoserinePhospho.ELM 6.0
94Phosphoserine.Swiss-Prot 53.0
322Phosphoserine (PKC
349Phosphoserine (PKC
472Phosphoserine (ATM)Phospho.ELM 6.0
480Phosphoserine (ATM)Phospho.ELM 6.0
Location(AA) Modification Resource
44Phosphoserine(PKA)HMM predict
51Phosphothreonine(MAPK)HMM predict
53Phosphothreonine(MAPK)HMM predict
79MethyllysineHMM predict
80MethyllysineHMM predict
94Phosphoserine(IKK)HMM predict
126Phosphothreonine(CK2)HMM predict
127Phosphothreonine(CK2)HMM predict
128Phosphoserine(CK1)HMM predict
164Phosphoserine(CK1)HMM predict
173Phosphoserine(CDC2)HMM predict
173O-linkedHMM predict
173Phosphoserine(MAPK)HMM predict
173Phosphoserine(CDK)HMM predict
175O-linkedHMM predict
176O-linkedHMM predict
176O-linkedHMM predict
177O-linkedHMM predict
177O-linkedHMM predict
181O-linkedHMM predict
247O-linkedHMM predict
248Phosphoserine(CDC2)HMM predict
248O-linkedHMM predict
265Phosphothreonine(PKC)HMM predict
292Phosphoserine(CK1)HMM predict
296Phosphoserine(IKK)HMM predict
302O-linkedHMM predict
303O-linkedHMM predict
303O-linkedHMM predict
307Phosphothreonine(CDK)HMM predict
307Phosphothreonine(CDC2)HMM predict
310Phosphoserine(CDC2)HMM predict
310O-linkedHMM predict
314O-linkedHMM predict
315Phosphothreonine(CDC2)HMM predict
315Phosphothreonine(CDK)HMM predict
320Phosphoserine(IKK)HMM predict
349Phosphoserine(PKC)HMM predict
370Phosphoserine(CK1)HMM predict
371Phosphoserine(CK1)HMM predict
411Phosphotyrosine(INSR)HMM predict
419Phosphoserine(CK2)HMM predict
419Phosphoserine(CK1)HMM predict
419PhosphoserineHMM predict
420Phosphoserine(CK1)HMM predict
424Phosphoserine(CK1)HMM predict
424Phosphoserine(ATM)HMM predict
428PhosphoserineHMM predict
428Phosphoserine(ATM)HMM predict
428Phosphoserine(CDC2)HMM predict
437O-linkedHMM predict
447O-linkedHMM predict
448Phosphothreonine(PKC)HMM predict
472Phosphoserine(ATM)HMM predict
480Phosphoserine(ATM)HMM predict
480Phosphoserine(IKK)HMM predict
482Phosphoserine(IKK)HMM predict
482Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001880
  • Location:chr2 175647253-175741142
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 175740687 175741627 940 15
PolII HeLaGSE12783 175739876 175742442 2566 17
Rb GrowingGSE19898 175741116 175741538 422 185
Rb QuiescentGSE19898 175741080 175741577 497 186
Rb SenescentGSE19898 175740666 175741794 1128 88
p130 SenescentGSE19898 175740614 175741777 1163 53
p130 shRbSenescentGSE19898 175740669 175741795 1126 90
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 175635795 175636381 586 11166
Nanog ESGSE20650 175630063 175630651 588 16897
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 175740687 175741559 872 0
GABP k562GSE8489 175655049 175655825 776 0
H3ac HepG2E 175739795 175741342 1547 0
P300 T30-glioblastomaGSE21026 175727235 175728366 1131 0
PHF8 293TGSE20725 175740337 175741818 1481 0
PHF8 Hs68minusFBSGSE20725 175740409 175741331 922 0
PHF8 Hs68plusFBSGSE20725 175740074 175741632 1558 0
TAF k562GSE8489 175738938 175741037 2099 0
TFAP2C MCF7GSE21234 175740577 175741471 894 0
USF1 HepG2E 175740376 175741291 915 0
USF2 HepG2E 175740174 175741342 1168 0
hScc1 BcellGSE12603 175684083 175684689 606 0
hScc1 CdLSGSE12603 175684083 175684689 606 0
p130 shRbQuiescentGSE19898 175740311 175741713 1402 0
p63 keratinocytesGSE17611 175699333 175700183 850 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-155 hsa-mir-155 21 20003307
hsa-miR-155* hsa-mir-155 21 20003307
hsa-miR-17 hsa-mir-17 13 20003307
hsa-miR-17* hsa-mir-17 13 20003307
hsa-miR-198 hsa-mir-198 0 17849003
hsa-miR-206 hsa-mir-206 6 17849003
hsa-miR-21 hsa-mir-21 17 20003307
hsa-miR-21* hsa-mir-21 17 20003307
hsa-miR-224 hsa-mir-224 X 20023705
hsa-miR-424 hsa-mir-424 X 20003307
hsa-miR-424* hsa-mir-424 X 20003307
hsa-miR-92a hsa-mir-92a-1 13 20003307
hsa-miR-92a hsa-mir-92a-2 X 20003307
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15307 EST chr2 175858138 175858757 112 mRNA ATF2 chr2 175764514 175858404Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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