AutismKB 2.0

Annotation Detail for CREBBP


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Basic Information Top
Gene Symbol:CREBBP ( CBP,KAT3A,RSTS )
Gene Full Name: CREB binding protein
Band: 16p13.3
Quick LinksEntrez ID:1387; OMIM: 600140; Uniprot ID:CBP_HUMAN; ENSEMBL ID: ENSG00000005339; HGNC ID: 2348
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
121Phosphoserine.
124Phosphoserine.
274Phosphoserine.
601Omega-N-methylated arginine (By
625Omega-N-methylated arginine (By
1001Phosphothreonine.
1014N6-acetyllysine.
1030Phosphoserine.
1072Phosphoserine.
1216N6-acetyllysine.
1583N6-acetyllysine.
1588N6-acetyllysine.
1591N6-acetyllysine.
1592N6-acetyllysine.
1595N6-acetyllysine.
1597N6-acetyllysine.
1741N6-acetyllysine.
1744N6-acetyllysine.
1755Phosphoserine.
2063Phosphoserine.
2076Phosphoserine.
2079Phosphoserine.
Location(AA) Modifications Resource
302Phosphoserine (CaM-KIV)Phospho.ELM 6.0
437Phosphoserine (PKC
601Omega-N-methylated arginine (Bysimilarity).Swiss-Prot 53.0
625Omega-N-methylated arginine (Bysimilarity).Swiss-Prot 53.0
1588N6-acetyllysine.Swiss-Prot 53.0
1591N6-acetyllysine.Swiss-Prot 53.0
1592N6-acetyllysine.Swiss-Prot 53.0
1595N6-acetyllysine.Swiss-Prot 53.0
1597N6-acetyllysine.Swiss-Prot 53.0
2063PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
18Phosphoserine(PKG)HMM predict
19Phosphoserine(CDC2)HMM predict
88N-linkedHMM predict
90O-linkedHMM predict
93Phosphoserine(CDC2)HMM predict
124Phosphoserine(ATM)HMM predict
132Phosphoserine(PKA)HMM predict
132Phosphoserine(CK1)HMM predict
139O-linkedHMM predict
139Phosphoserine(IKK)HMM predict
140O-linkedHMM predict
141O-linkedHMM predict
141Phosphoserine(IKK)HMM predict
144O-linkedHMM predict
144O-linkedHMM predict
144Phosphothreonine(MAPK)HMM predict
148O-linkedHMM predict
165O-linkedHMM predict
165Phosphoserine(CDC2)HMM predict
165Phosphoserine(IKK)HMM predict
168O-linkedHMM predict
169O-linkedHMM predict
169O-linkedHMM predict
169O-linkedHMM predict
169Phosphoserine(ATM)HMM predict
182N-linkedHMM predict
220MethylarginineHMM predict
247O-linkedHMM predict
272N-linkedHMM predict
274Phosphoserine(CDC2)HMM predict
281Phosphoserine(ATM)HMM predict
302Phosphoserine(IKK)HMM predict
316N-linkedHMM predict
321N-linkedHMM predict
324N-linkedHMM predict
421N-linkedHMM predict
435N-linkedHMM predict
441N-linkedHMM predict
466N-linkedHMM predict
468O-linkedHMM predict
469Phosphoserine(CK1)HMM predict
472N-linkedHMM predict
579O-linkedHMM predict
584O-linkedHMM predict
585O-linkedHMM predict
641Phosphotyrosine(EGFR)HMM predict
641Phosphotyrosine(INSR)HMM predict
650Phosphotyrosine(Syk)HMM predict
650SulfotyrosineHMM predict
765Phosphoserine(CDC2)HMM predict
767O-linkedHMM predict
791Phosphoserine(ATM)HMM predict
801Phosphoserine(CDC2)HMM predict
803O-linkedHMM predict
820O-linkedHMM predict
851Phosphoserine(CDC2)HMM predict
851Phosphoserine(IKK)HMM predict
856O-linkedHMM predict
856Phosphothreonine(CDK)HMM predict
856PhosphothreonineHMM predict
861O-linkedHMM predict
861O-linkedHMM predict
862O-linkedHMM predict
862O-linkedHMM predict
873Phosphothreonine(CDC2)HMM predict
878Phosphothreonine(CDK)HMM predict
889O-linkedHMM predict
890O-linkedHMM predict
890Phosphothreonine(MAPK)HMM predict
890Phosphothreonine(CDK)HMM predict
893O-linkedHMM predict
893Phosphoserine(IKK)HMM predict
894O-linkedHMM predict
894O-linkedHMM predict
895O-linkedHMM predict
898O-linkedHMM predict
898O-linkedHMM predict
898Phosphothreonine(CDC2)HMM predict
898Phosphothreonine(MAPK)HMM predict
900O-linkedHMM predict
900O-linkedHMM predict
900Phosphothreonine(MAPK)HMM predict
902O-linkedHMM predict
902O-linkedHMM predict
902Phosphothreonine(MAPK)HMM predict
905O-linkedHMM predict
908O-linkedHMM predict
908O-linkedHMM predict
910O-linkedHMM predict
915O-linkedHMM predict
917O-linkedHMM predict
927O-linkedHMM predict
927Phosphothreonine(MAPK)HMM predict
932Phosphothreonine(CDC2)HMM predict
932Phosphothreonine(MAPK)HMM predict
932Phosphothreonine(CDK)HMM predict
938O-linkedHMM predict
941O-linkedHMM predict
941Phosphothreonine(CDK)HMM predict
944Phosphoserine(CDK)HMM predict
945O-linkedHMM predict
945O-linkedHMM predict
945Phosphoserine(ATM)HMM predict
950O-linkedHMM predict
950Phosphothreonine(MAPK)HMM predict
959Phosphothreonine(MAPK)HMM predict
959Phosphothreonine(CDK)HMM predict
962Phosphoserine(ATM)HMM predict
976O-linkedHMM predict
980O-linkedHMM predict
983O-linkedHMM predict
985Phosphoserine(ATM)HMM predict
1065Phosphoserine(CK1)HMM predict
1066Phosphoserine(CK1)HMM predict
1067Phosphoserine(CK1)HMM predict
1068N-linkedHMM predict
1070O-linkedHMM predict
1075O-linkedHMM predict
1076O-linkedHMM predict
1076Phosphoserine(CDC2)HMM predict
1076Phosphoserine(IKK)HMM predict
1078Phosphoserine(ATM)HMM predict
1200S-palmitoylHMM predict
1248N-linkedHMM predict
1256Phosphoserine(ATM)HMM predict
1256Phosphoserine(IKK)HMM predict
1272N-linkedHMM predict
1331Phosphothreonine(PKC)HMM predict
1527Phosphothreonine(PKC)HMM predict
1572O-linkedHMM predict
1572Phosphoserine(CK2)HMM predict
1574O-linkedHMM predict
1578Phosphoserine(ATM)HMM predict
1596N-linkedHMM predict
1622Phosphotyrosine(INSR)HMM predict
1754Phosphoserine(CK1)HMM predict
1754Phosphoserine(CK2)HMM predict
1755Phosphoserine(ATM)HMM predict
1763Phosphoserine(CDC2)HMM predict
1763Phosphoserine(IKK)HMM predict
1771Phosphoserine(PKG)HMM predict
1789N-linkedHMM predict
1827S-palmitoylHMM predict
1871Phosphothreonine(PKA)HMM predict
1884O-linkedHMM predict
1884Phosphoserine(CDC2)HMM predict
1884Phosphoserine(MAPK)HMM predict
1886O-linkedHMM predict
1886O-linkedHMM predict
1887O-linkedHMM predict
1892O-linkedHMM predict
1892O-linkedHMM predict
1892Phosphothreonine(MAPK)HMM predict
1898O-linkedHMM predict
1898O-linkedHMM predict
1898Phosphoserine(IKK)HMM predict
1902Phosphothreonine(CDC2)HMM predict
1902Phosphothreonine(MAPK)HMM predict
1902Phosphothreonine(CDK)HMM predict
1912O-linkedHMM predict
1912Phosphoserine(CDC2)HMM predict
1917O-linkedHMM predict
1931O-linkedHMM predict
1934O-linkedHMM predict
1935O-linkedHMM predict
1978N-linkedHMM predict
1979N-linkedHMM predict
1985MethylarginineHMM predict
1990Phosphothreonine(MAPK)HMM predict
2061O-linkedHMM predict
2063Phosphoserine(CDC2)HMM predict
2076Phosphoserine(CDC2)HMM predict
2076Phosphoserine(IKK)HMM predict
2078Phosphoserine(CK1)HMM predict
2078PhosphoserineHMM predict
2079Phosphoserine(CDC2)HMM predict
2079Phosphoserine(IKK)HMM predict
2123Phosphoserine(IKK)HMM predict
2307Phosphoserine(CDC2)HMM predict
2328O-linkedHMM predict
2337O-linkedHMM predict
2345Phosphoserine(CDC2)HMM predict
2356Phosphoserine(ATM)HMM predict
2356Phosphoserine(IKK)HMM predict
2362Phosphoserine(CDC2)HMM predict
2362Phosphoserine(CDK)HMM predict
2364O-linkedHMM predict
2364Phosphoserine(CDC2)HMM predict
2382Phosphoserine(CDC2)HMM predict
2414Phosphothreonine(MAPK)HMM predict
2414Phosphothreonine(CDK)HMM predict
2416Phosphoserine(MAPK)HMM predict
2425Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004380
  • Location:chr16 3716569-3870711
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 3870732 3871657 925 483
Oct1 HelaGSE14283 3873383 3873435 52 2698
Oct1 HelaGSE14283 3876817 3876847 30 6121
PHF8 HeLaGSE20725 3870204 3871827 1623 304
PHF8 Hs68plusFBSGSE20725 3870430 3871423 993 215
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 3716251 3716434 183 227
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 3717810 3717981 171 0
CTCF G2GSE9613 3720475 3721094 619 0
CTCF G2GSE9613 3721574 3722018 444 0
CTCF G2GSE9613 3724614 3725201 587 0
CTCF G2GSE9613 3734110 3734294 184 0
CTCF G2GSE9613 3760512 3761025 513 0
CTCF G2GSE9613 3854139 3854341 202 0
CTCF G2GSE9613 3862507 3862831 324 0
ER Fulvestrant-MCF7GSE14664 3785292 3785353 61 0
FoxA1 MCF7MACSdata 3762379 3762655 276 0
FoxA1 MCF7MACSdata 3810206 3810458 252 0
H3ac HepG2E 3868255 3869624 1369 0
Myc K562GSE19551 3836535 3836894 359 0
Myc hESGSE17917 3788016 3788492 476 0
NFkBII GM12878GSE19485 3777530 3778895 1365 0
NRSF pAbJurkat 3760613 3761025 412 0
Nanog hESGSE18292 3832100 3832472 372 0
Oct1 H2O2-HelaGSE14283 3840074 3840100 26 0
Oct1 H2O2-HelaGSE14283 3855086 3855115 29 0
Oct1 HelaGSE14283 3768621 3768658 37 0
Oct1 HelaGSE14283 3774358 3774450 92 0
Oct1 HelaGSE14283 3830574 3830614 40 0
Oct1 HelaGSE14283 3840073 3840100 27 0
RUNX JurkatGSE17954 3779616 3779859 243 0
Rb GrowingGSE19898 3762413 3762591 178 0
STAT1 HeLaGSE12783 3794055 3795153 1098 0
TFAP2C MCF7GSE21234 3761450 3761988 538 0
TFAP2C MCF7GSE21234 3815918 3816284 366 0
hScc1 BcellGSE12603 3862387 3862831 444 0
hScc1 BcellGSE12603 3869385 3869917 532 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 20395958
hsa-miR-122* hsa-mir-122 18 20395958
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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