AutismKB 2.0

Annotation Detail for CRK


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Basic Information Top
Gene Symbol:CRK ( CRKII )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)
Band: 17p13.3
Quick LinksEntrez ID:1398; OMIM: 164762; Uniprot ID:CRK_HUMAN; ENSEMBL ID: ENSG00000167193; HGNC ID: 2362
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
41Phosphoserine (By similarity).
42Phosphothreonine (By similarity).
74Phosphoserine.
83Phosphoserine.
136Phosphotyrosine.
221Phosphotyrosine.
239Phosphotyrosine.
251Phosphotyrosine.
Location(AA) Modifications Resource
41Phosphoserine (By similarity).Swiss-Prot 53.0
42Phosphothreonine (By similarity).Swiss-Prot 53.0
221Phosphotyrosine.Swiss-Prot 53.0
221Phosphotyrosine (Abl;EGFR;IGF)Phospho.ELM 6.0
239Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
19Phosphoserine(PKG)HMM predict
63N-linkedHMM predict
74O-linkedHMM predict
74Phosphoserine(CDC2)HMM predict
74Phosphoserine(IKK)HMM predict
83Phosphoserine(CDC2)HMM predict
136Phosphotyrosine(EGFR)HMM predict
196Phosphoserine(IKK)HMM predict
221Phosphotyrosine(INSR)HMM predict
221Phosphotyrosine(Abl)HMM predict
225O-linkedHMM predict
228Phosphothreonine(CDK)HMM predict
239Phosphotyrosine(EGFR)HMM predict
270N-linkedHMM predict
283MethylarginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016823
  • Location:chr17 1272209-1306293
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM18526GSE19485 1305797 1306956 1159 83
P300 T0-glioblastomaGSE21026 1306057 1306752 695 111
PHF8 293TGSE20725 1305719 1306985 1266 59
Rb SenescentGSE19898 1306115 1306591 476 60
p130 SenescentGSE19898 1306064 1306741 677 109
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 1305764 1306722 958 0
FoxA1 MCF7MACSdata 1299594 1299691 97 0
H3K4me2 HCT116GSE10453 1304585 1305356 771 0
H3K4me3 colorectalcancer 1304880 1305394 514 0
H3ac HepG2E 1304622 1305719 1097 0
NFkBII GM12892GSE19485 1281258 1282397 1139 0
NFkBII GM15510GSE19485 1305611 1306844 1233 0
P300 T30-glioblastomaGSE21026 1304964 1306887 1923 0
PHF8 HeLaGSE20725 1305455 1307117 1662 0
RARG MCF7GSE15244 1304657 1305308 651 0
Rb GrowingGSE19898 1305312 1305580 268 0
Rb SenescentGSE19898 1272933 1273294 361 0
hScc1 BcellGSE12603 1305308 1306272 964 0
p130 QuiescentGSE19898 1273059 1273226 167 0
p130 SenescentGSE19898 1272940 1273466 526 0
p130 shRbSenescentGSE19898 1273220 1273453 233 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-126 hsa-mir-126 9 19767772
hsa-miR-126 hsa-mir-126 9 18602365
hsa-miR-126* hsa-mir-126 9 19767772
hsa-miR-126* hsa-mir-126 9 18602365
hsa-miR-218 hsa-mir-218-1 4 19767772
hsa-miR-218 hsa-mir-218-2 5 19767772
hsa-miR-224 hsa-mir-224 X 19767772
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018