AutismKB 2.0

Annotation Detail for PARP1


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Basic Information Top
Gene Symbol:PARP1 ( ADPRT,ADPRT 1,ADPRT1,PARP,PARP-1,PPOL,pADPRT-1 )
Gene Full Name: poly (ADP-ribose) polymerase 1
Band: 1q42.12
Quick LinksEntrez ID:142; OMIM: 173870; Uniprot ID:PARP1_HUMAN; ENSEMBL ID: ENSG00000143799; HGNC ID: 270
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
41Phosphoserine.
97N6-acetyllysine.
105N6-acetyllysine.
131N6-acetyllysine.
179Phosphoserine.
209Nuclear localization signal.
226Nuclear localization signal.
368Phosphothreonine.
407PolyADP-ribosyl glutamic acid
413PolyADP-ribosyl glutamic acid
435PolyADP-ribosyl glutamic acid
437PolyADP-ribosyl glutamic acid
444PolyADP-ribosyl glutamic acid
445PolyADP-ribosyl glutamic acid
448PolyADP-ribosyl glutamic acid
456PolyADP-ribosyl glutamic acid
471PolyADP-ribosyl glutamic acid
484PolyADP-ribosyl glutamic acid
488PolyADP-ribosyl glutamic acid
491PolyADP-ribosyl glutamic acid
513PolyADP-ribosyl glutamic acid
514PolyADP-ribosyl glutamic acid
520PolyADP-ribosyl glutamic acid
600N6-acetyllysine.
621N6-acetyllysine.
782Phosphoserine.
Location(AA) Modifications Resource
407PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
413PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
435PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
437PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
444PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
445PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
448PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
456PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
471PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
484PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
488PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
491PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
513PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
514PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
520PolyADP-ribosyl glutamic acid(Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
9Phosphotyrosine(INSR)HMM predict
121N-linkedHMM predict
179Phosphoserine(ATM)HMM predict
327Phosphothreonine(CDC2)HMM predict
327Phosphothreonine(MAPK)HMM predict
327Phosphothreonine(CDK)HMM predict
364Phosphoserine(IKK)HMM predict
364O-linkedHMM predict
368O-linkedHMM predict
368Phosphothreonine(MAPK)HMM predict
368O-linkedHMM predict
368PhosphothreonineHMM predict
372O-linkedHMM predict
372O-linkedHMM predict
372O-linkedHMM predict
373O-linkedHMM predict
381N-linkedHMM predict
455Phosphoserine(CAMK2)HMM predict
630N-linkedHMM predict
645SulfotyrosineHMM predict
663Phosphoserine(CDK)HMM predict
721Phosphoserine(ATM)HMM predict
808Phosphoserine(CK2)HMM predict
808Phosphoserine(CK1)HMM predict
889Phosphotyrosine(Jak)HMM predict
980N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001618
  • Location:chr1 224615128-224662413
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 224678896 224679094 198 16582
CTCF CD4SISSRdata 224678896 224679094 198 16582
CTCF G2GSE9613 224679021 224679325 304 16760
PHF8 293TGSE20725 224661643 224663305 1662 61
Rb QuiescentGSE19898 224662338 224662510 172 11
TFAP2C MCF7GSE21234 224662498 224662878 380 275
hScc1 BcellGSE12603 224678901 224679173 272 16624
hScc1 CdLSGSE12603 224678677 224679517 840 16684
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
VDR GM10861-stimGSE22484 224602569 224605494 2925 11097
hScc1 BcellGSE12603 224608623 224608882 259 6376
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 224626193 224626442 249 0
CTCF G2GSE9613 224657801 224658045 244 0
CTCF G2GSE9613 224662003 224662635 632 0
H3K4me3 colorectalcancer 224661517 224661861 344 0
Myc hESGSE17917 224662144 224662528 384 0
PHF8 HeLaGSE20725 224661705 224662903 1198 0
Rb GrowingGSE19898 224661743 224662010 267 0
Rb QuiescentGSE19898 224661587 224662061 474 0
Rb SenescentGSE19898 224661673 224662540 867 0
Rb shRbQuiescentGSE19898 224661686 224661990 304 0
Rb shRbSenescenceGSE19898 224661711 224662102 391 0
Sox2 hESGSE18292 224659145 224659670 525 0
TFAP2C MCF7GSE21234 224659017 224659384 367 0
TFAP2C MCF7GSE21234 224660664 224661351 687 0
TFAP2C MCF7GSE21234 224661562 224662038 476 0
hScc1 BcellGSE12603 224662037 224662635 598 0
p130 QuiescentGSE19898 224661707 224661999 292 0
p130 shRbSenescentGSE19898 224661721 224662020 299 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181a hsa-mir-181a-2 9 21274007
hsa-miR-181a hsa-mir-181a-1 1 21274007
hsa-miR-374a hsa-mir-374a X 21274007
hsa-miR-374a* hsa-mir-374a X 21274007
hsa-miR-378 hsa-mir-378 5 20353610
hsa-miR-378* hsa-mir-378 5 20353610
hsa-miR-519a hsa-mir-519a-1 19 21274007
hsa-miR-519a hsa-mir-519a-2 19 21274007
hsa-miR-630 hsa-mir-630 15 21274007
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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