AutismKB 2.0

Annotation Detail for PLEKHA7


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Basic Information Top
Gene Symbol:PLEKHA7 ( DKFZp686M22243 )
Gene Full Name: pleckstrin homology domain containing, family A member 7
Band: 11p15
Quick LinksEntrez ID:144100; OMIM: 612686; Uniprot ID:PKHA7_HUMAN; ENSEMBL ID: ENSG00000166689; HGNC ID: 27049
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
365Phosphotyrosine (By similarity).
536Phosphoserine (By similarity).
545Phosphoserine (By similarity).
604Phosphoserine.
612Phosphoserine.
903Phosphoserine.
907Phosphoserine.
909Phosphothreonine.
Location(AA) Modifications Resource
365Phosphotyrosine (By similarity).Swiss-Prot 53.0
536Phosphoserine (By similarity).Swiss-Prot 53.0
545Phosphoserine (By similarity).Swiss-Prot 53.0
612Phosphoserine (By similarity).Swiss-Prot 53.0
903Phosphoserine.Swiss-Prot 53.0
907Phosphoserine (By similarity).Swiss-Prot 53.0
909Phosphothreonine.Swiss-Prot 53.0
Location(AA) Modification Resource
65Phosphothreonine(CK2)HMM predict
79Phosphothreonine(PKC)HMM predict
118Phosphoserine(MAPK)HMM predict
118Phosphoserine(PKB)HMM predict
123O-linkedHMM predict
124O-linkedHMM predict
217Phosphoserine(MAPK)HMM predict
217Phosphoserine(CDC2)HMM predict
244N-linkedHMM predict
250Phosphoserine(IKK)HMM predict
287Phosphoserine(CDC2)HMM predict
288Phosphoserine(CK1)HMM predict
305N-linkedHMM predict
347Phosphoserine(ATM)HMM predict
359PhosphoserineHMM predict
363Phosphoserine(CDC2)HMM predict
366Phosphoserine(IKK)HMM predict
366Phosphoserine(MAPK)HMM predict
407N-linkedHMM predict
430Phosphoserine(IKK)HMM predict
465Phosphoserine(IKK)HMM predict
470Phosphotyrosine(EGFR)HMM predict
472Phosphothreonine(PKC)HMM predict
481Phosphoserine(PKB)HMM predict
485Phosphoserine(ATM)HMM predict
485Phosphoserine(CDC2)HMM predict
485Phosphoserine(CDK)HMM predict
536Phosphoserine(IKK)HMM predict
556Phosphoserine(IKK)HMM predict
565Phosphoserine(PKB)HMM predict
565O-linkedHMM predict
569Phosphoserine(CDC2)HMM predict
569Phosphoserine(ATM)HMM predict
569Phosphoserine(CDK)HMM predict
571O-linkedHMM predict
595Phosphothreonine(PKC)HMM predict
612Phosphoserine(CDC2)HMM predict
623N-linkedHMM predict
637Phosphotyrosine(Jak)HMM predict
643Phosphoserine(CAMK2)HMM predict
656Phosphotyrosine(Jak)HMM predict
768PhosphoserineHMM predict
854O-linkedHMM predict
856Phosphoserine(CK1)HMM predict
856O-linkedHMM predict
857O-linkedHMM predict
867O-linkedHMM predict
871O-linkedHMM predict
871Phosphoserine(CDK)HMM predict
871PhosphoserineHMM predict
871Phosphoserine(CDC2)HMM predict
875Phosphothreonine(MAPK)HMM predict
902Phosphothreonine(PKA)HMM predict
903Phosphoserine(CDC2)HMM predict
903Phosphoserine(PKA)HMM predict
907Phosphoserine(CDK)HMM predict
907Phosphoserine(CDC2)HMM predict
960Phosphoserine(PKA)HMM predict
984Phosphotyrosine(EGFR)HMM predict
1013Phosphothreonine(PKC)HMM predict
1029O-linkedHMM predict
1037Phosphothreonine(PKC)HMM predict
1063Phosphoserine(CK1)HMM predict
1072Phosphoserine(PKG)HMM predict
1094Phosphothreonine(PKC)HMM predict
1110Phosphoserine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_175058
  • Location:chr11 16765787-16992534
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 16992348 16993154 806 217
H3ac HepG2E 16994035 16994396 361 1681
Nanog ESGSE20650 16999720 17000276 556 7464
TFAP2C MCF7GSE21234 16999720 17000141 421 7396
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 16763718 16763941 223 1958
CTCF CD4SISSRdata 16763718 16763941 223 1958
ER MCF7GSE19013 16761532 16762153 621 3945
Oct1 HelaGSE14283 16764022 16764055 33 1749
hScc1 BcellGSE12603 16763475 16764346 871 1877
hScc1 CdLSGSE12603 16763586 16764566 980 1712
hScc1 G2GSE9613 16763439 16764020 581 2058
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 16959619 16960301 682 0
CTCF CD4GSE12889 16766583 16766817 234 0
CTCF CD4GSE12889 16798376 16798695 319 0
CTCF CD4SISSRdata 16766583 16766817 234 0
CTCF CD4SISSRdata 16798376 16798695 319 0
CTCF HelaGSE12889 16766444 16766783 339 0
CTCF HelaGSE12889 16924132 16924307 175 0
CTCF JurkatGSE12889 16766450 16766840 390 0
ER MCF7GSE19013 16934373 16935445 1072 0
ER MCF7GSE19013 16941581 16942079 498 0
ER MCF7GSE19013 16964398 16965743 1345 0
ER MCF7GSE19013 16967380 16968102 722 0
FOXA1 DLD1GSE12801 16896526 16896995 469 0
FOXA1 DLD1GSE12801 16955501 16955866 365 0
FOXA1 DLD1GSE12801 16982889 16983344 455 0
FOXA1 MCF7GSE15244 16766310 16766820 510 0
FOXA1 MCF7GSE15244 16784751 16785412 661 0
FOXA1 MCF7GSE15244 16837746 16838378 632 0
FOXA1 MCF7GSE15244 16871583 16872275 692 0
FOXA1 MCF7GSE15244 16933326 16933682 356 0
FOXA1 MCF7GSE15244 16934953 16935293 340 0
FOXA1 MCF7GSE15244 16937548 16937873 325 0
FOXA1 MCF7GSE15244 16955294 16956102 808 0
FOXA1 MCF7GSE15244 16964461 16966427 1966 0
FOXA1 MCF7GSE15244 16982889 16983344 455 0
FOXA1 MCF7GSE15244 16990850 16991569 719 0
FoxA1 MCF7MACSdata 16982936 16983130 194 0
GATA3 MCF7GSE15244 16934917 16935293 376 0
Gata2 K562GSE18868 16835063 16835892 829 0
H3ac HepG2E 16889591 16889951 360 0
H3ac HepG2E 16952768 16953141 373 0
HIF1 NormHepG2 16963319 16963878 559 0
KLF4 hESGSE17917 16992381 16992617 236 0
NRSF pAbJurkat 16796487 16796661 174 0
NRSF pAbJurkat 16901472 16902286 814 0
NRSF pAbJurkat 16979077 16979305 228 0
Nanog ESGSE20650 16875572 16876159 587 0
Nanog ESGSE20650 16934913 16935424 511 0
Nanog hESGSE18292 16790528 16790675 147 0
Nanog hESGSE18292 16811164 16811413 249 0
Nanog hESGSE18292 16890992 16891221 229 0
Nanog hESGSE18292 16934852 16935467 615 0
Nanog hESGSE18292 16955855 16956636 781 0
Oct1 HelaGSE14283 16801972 16802002 30 0
Oct1 HelaGSE14283 16921073 16921138 65 0
Oct1 HelaGSE14283 16988141 16988171 30 0
P300 T30-glioblastomaGSE21026 16769484 16770417 933 0
P300 T30-glioblastomaGSE21026 16959427 16960537 1110 0
P300 T30-glioblastomaGSE21026 16990770 16991648 878 0
RARA MCF7GSE15244 16783950 16785556 1606 0
RARA MCF7GSE15244 16871583 16872160 577 0
RARA MCF7GSE15244 16934807 16935293 486 0
RARA MCF7GSE15244 16937485 16937948 463 0
RARA MCF7GSE15244 16964340 16966463 2123 0
RARA MCF7GSE15244 16973795 16974120 325 0
RARA MCF7GSE15244 16979810 16980135 325 0
RARA MCF7GSE15244 16982889 16983174 285 0
RARA MCF7GSE15244 16990699 16991488 789 0
RARG MCF7GSE15244 16783950 16785521 1571 0
RARG MCF7GSE15244 16790257 16790524 267 0
RARG MCF7GSE15244 16914549 16914849 300 0
RARG MCF7GSE15244 16934807 16935293 486 0
RARG MCF7GSE15244 16937440 16937907 467 0
RARG MCF7GSE15244 16938667 16938958 291 0
RARG MCF7GSE15244 16964461 16966389 1928 0
RARG MCF7GSE15244 16990561 16991569 1008 0
Sox2 hESGSE18292 16913929 16914269 340 0
TAF HelaGSE8489 16989272 16989839 567 0
TFAP2C MCF7GSE21234 16766456 16767078 622 0
TFAP2C MCF7GSE21234 16784885 16785493 608 0
TFAP2C MCF7GSE21234 16837642 16838347 705 0
TFAP2C MCF7GSE21234 16902709 16903229 520 0
TFAP2C MCF7GSE21234 16934844 16935338 494 0
TFAP2C MCF7GSE21234 16938313 16938987 674 0
TFAP2C MCF7GSE21234 16964644 16965119 475 0
TFAP2C MCF7GSE21234 16965241 16966290 1049 0
TFAP2C MCF7GSE21234 16988848 16989489 641 0
USF1 HepG2E 16963248 16964573 1325 0
VDR GM10855-stimGSE22484 16964174 16965421 1247 0
hScc1 BcellGSE12603 16766391 16766888 497 0
hScc1 BcellGSE12603 16798507 16798892 385 0
hScc1 BcellGSE12603 16903102 16904097 995 0
hScc1 BcellGSE12603 16913931 16914207 276 0
hScc1 BcellGSE12603 16923929 16924860 931 0
hScc1 BcellGSE12603 16940887 16941030 143 0
hScc1 BcellGSE12603 16991646 16992733 1087 0
hScc1 CdLSGSE12603 16766353 16766820 467 0
hScc1 CdLSGSE12603 16798507 16798928 421 0
hScc1 CdLSGSE12603 16903448 16903991 543 0
hScc1 CdLSGSE12603 16913826 16914207 381 0
hScc1 CdLSGSE12603 16923827 16925080 1253 0
hScc1 CdLSGSE12603 16992321 16992733 412 0
hScc1 G2GSE9613 16766353 16766888 535 0
hScc1 G2GSE9613 16798507 16798892 385 0
hScc1 G2GSE9613 16923862 16924651 789 0
p130 shRbQuiescentGSE19898 16769338 16770045 707 0
p130 shRbSenescentGSE19898 16766723 16766990 267 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
4169 EST chr11 16992120 17030360 178 mRNA PLEKHA7 chr11 16765787 16992535Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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