AutismKB 2.0

Annotation Detail for ADRB2


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Basic Information Top
Gene Symbol:ADRB2 ( ADRB2R,ADRBR,B2AR,BAR,BETA2AR )
Gene Full Name: adrenergic, beta-2-, receptor, surface
Band: 5q32
Quick LinksEntrez ID:154; OMIM: 109690; Uniprot ID:ADRB2_HUMAN; ENSEMBL ID: ENSG00000169252; HGNC ID: 286
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
6N-linked (GlcNAc...) (Probable).
15N-linked (GlcNAc...) (Probable).
141Phosphotyrosine.
246Phosphoserine.
261Phosphoserine; by PKA (Potential).
262Phosphoserine; by PKA (Potential).
345Phosphoserine; by PKA.
346Phosphoserine; by PKA.
355Phosphoserine; by BARK (Probable).
356Phosphoserine; by BARK (Probable).
Location(AA) Modifications Resource
6N-linked (GlcNAc...) (Probable).Swiss-Prot 53.0
15N-linked (GlcNAc...) (Probable).Swiss-Prot 53.0
132Phosphotyrosine (IGF1R)Phospho.ELM 6.0
141Phosphotyrosine (IGF1R)Phospho.ELM 6.0
261Phosphoserine (by PKA) (Potential).Swiss-Prot 53.0
262Phosphoserine (by PKA) (Potential).Swiss-Prot 53.0
262Phosphoserine (PKA
326PhosphotyrosinePhospho.ELM 6.0
341S-palmitoyl cysteine.Swiss-Prot 53.0
345Phosphoserine (PKA
345Phosphoserine (by PKA).Swiss-Prot 53.0
346Phosphoserine (PKA
346Phosphoserine (by PKA).Swiss-Prot 53.0
355Phosphoserine (by BARK) (Probable).Swiss-Prot 53.0
355Phosphoserine (GRK
356Phosphoserine (GRK
356Phosphoserine (by BARK) (Probable).Swiss-Prot 53.0
384Phosphothreonine (GRK-2;GRK-5)Phospho.ELM 6.0
393Phosphothreonine (GRK-5)Phospho.ELM 6.0
396Phosphoserine (GRK-2;GRK-5)Phospho.ELM 6.0
401Phosphoserine (GRK-2;GRK-5)Phospho.ELM 6.0
407Phosphoserine (GRK-2;GRK-5)Phospho.ELM 6.0
411Phosphoserine (GRK-5)Phospho.ELM 6.0
Location(AA) Modification Resource
15N-linkedHMM predict
66Phosphothreonine(PKC)HMM predict
187N-linkedHMM predict
346Phosphoserine(PKG)HMM predict
346Phosphoserine(PKA)HMM predict
346Phosphoserine(PKC)HMM predict
350Phosphotyrosine(INSR)HMM predict
354Phosphotyrosine(INSR)HMM predict
366Phosphotyrosine(INSR)HMM predict
366Phosphotyrosine(Syk)HMM predict
406S-farnesylHMM predict
407SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000024
  • Location:chr5 148186348-148188380
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 148185265 148185632 367 900
Rb SenescentGSE19898 148186093 148186512 419 46
TFAP2C MCF7GSE21234 148168511 148168964 453 17611
p130 QuiescentGSE19898 148186218 148186375 157 52
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 148188311 148188553 242 52
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 148185890 148187081 1191 0
hScc1 BcellGSE12603 148186186 148187081 895 0
hScc1 G2GSE9613 148185890 148187188 1298 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-21 hsa-mir-21 17 18508928
hsa-miR-21* hsa-mir-21 17 18508928
No data
Cis-Nats regulation Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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