AutismKB 2.0

Annotation Detail for DARS


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Basic Information Top
Gene Symbol:DARS ( DKFZp781B11202,MGC111579 )
Gene Full Name: aspartyl-tRNA synthetase
Band: 2q21.3
Quick LinksEntrez ID:1615; OMIM: 603084; Uniprot ID:SYDC_HUMAN; ENSEMBL ID: ENSG00000115866; HGNC ID: 2678
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
74N6-acetyllysine.
238Phosphoserine.
249Phosphoserine.
374N6-acetyllysine.
500Phosphothreonine; by PKA (Potential).
Location(AA) Modifications Resource
500Phosphothreonine (by PKA) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
37Phosphoserine(ATM)HMM predict
68Phosphothreonine(PKC)HMM predict
279Phosphothreonine(PKC)HMM predict
369Phosphoserine(CK1)HMM predict
370Phosphothreonine(CDC2)HMM predict
389SulfotyrosineHMM predict
416Phosphotyrosine(Syk)HMM predict
489Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001349
  • Location:chr2 136380723-136459691
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 136474035 136474335 300 14494
Rb GrowingGSE19898 136459758 136460039 281 207
Rb QuiescentGSE19898 136459507 136460251 744 188
Rb SenescentGSE19898 136459337 136460291 954 123
Rb shRbQuiescentGSE19898 136459937 136460204 267 379
hScc1 BcellGSE12603 136459829 136460089 260 268
p130 shRbSenescentGSE19898 136459151 136460265 1114 17
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 136371609 136371897 288 8971
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 136459207 136459547 340 0
Fos K562GSE19551 136422843 136423358 515 0
H3K4me3 colorectalcancer 136458481 136459160 679 0
H3ac HepG2E 136458412 136460393 1981 0
HIF1 HypoHepG2 136458728 136460049 1321 0
PHF8 HeLaGSE20725 136458669 136460051 1382 0
PHF8 Hs68minusFBSGSE20725 136458832 136460380 1548 0
PHF8 Hs68plusFBSGSE20725 136458684 136460286 1602 0
Rb GrowingGSE19898 136459440 136459743 303 0
Rb shRbQuiescentGSE19898 136459474 136459757 283 0
STAT1 HeLaGSE12782 136458520 136460605 2085 0
Stat6 IL-4-hr1GSE17850 136434399 136435105 706 0
TAF HelaGSE8489 136458481 136458951 470 0
TAF k562GSE8489 136456663 136457023 360 0
TAF k562GSE8489 136458445 136458951 506 0
TFAP2C MCF7GSE21234 136400714 136401162 448 0
hScc1 BcellGSE12603 136390267 136390516 249 0
p130 QuiescentGSE19898 136459076 136460166 1090 0
p130 shRbQuiescentGSE19898 136458797 136460148 1351 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15063 EST chr2 136576572 136598651 119 mRNA DARS chr2 136497985 136576954Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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