AutismKB 2.0

Annotation Detail for SPRED1


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Basic Information Top
Gene Symbol:SPRED1 ( FLJ33903,NFLS )
Gene Full Name: sprouty-related, EVH1 domain containing 1
Band: 15q14
Quick LinksEntrez ID:161742; OMIM: 609291; Uniprot ID:SPRE1_HUMAN; ENSEMBL ID: ENSG00000166068; HGNC ID: 20249
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
238Phosphoserine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
7Phosphothreonine(CK2)HMM predict
14Phosphotyrosine(Jak)HMM predict
23Phosphothreonine(PKC)HMM predict
124Phosphoserine(ATM)HMM predict
147Phosphoserine(CK1)HMM predict
148Phosphoserine(CK1)HMM predict
149Phosphoserine(CK1)HMM predict
222Phosphoserine(CK1)HMM predict
238Phosphoserine(PKB)HMM predict
377Phosphotyrosine(INSR)HMM predict
416S-palmitoylHMM predict
429CysteineHMM predict
433S-farnesylHMM predict
434GlycineHMM predict
436S-farnesylHMM predict
436S-palmitoylHMM predict
438GlycineHMM predict
439LysineHMM predict
441LysineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_152594
  • Location:chr15 36331807-36433532
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 36331029 36331170 141 708
ETS1 JurkatGSE17954 36330990 36332152 1162 237
H3ac HepG2E 36331053 36331740 687 411
Oct4 hESGSE21916 36330444 36331786 1342 693
Rb GrowingGSE19898 36331350 36331586 236 340
USF1 HepG2E 36331094 36331629 535 446
USF2 HepG2E 36330793 36331695 902 564
hScc1 CdLSGSE12603 36330757 36332161 1404 349
p130 QuiescentGSE19898 36330711 36331602 891 651
p130 shRbSenescentGSE19898 36331262 36331689 427 332
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 36433820 36434214 394 485
CTCF CD4SISSRdata 36433820 36434214 394 485
KLF4 hESGSE17917 36437383 36437539 156 3929
hScc1 BcellGSE12603 36433809 36434338 529 541
hScc1 CdLSGSE12603 36433772 36434420 648 564
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 36330347 36333541 3194 0
ER E2-MCF7GSE14664 36416092 36416178 86 0
H3K4me3 colorectalcancer 36332826 36333620 794 0
H3ac HepG2E 36332852 36333935 1083 0
KLF4 hESGSE17917 36430973 36431279 306 0
Oct1 HelaGSE14283 36361982 36362011 29 0
RARA MCF7GSE15244 36333167 36334067 900 0
USF1 HepG2E 36333167 36334881 1714 0
hScc1 BcellGSE12603 36331053 36332683 1630 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-126 hsa-mir-126 9 20844033
hsa-miR-126 hsa-mir-126 9 18987025
hsa-miR-126 hsa-mir-126 9 18694566
hsa-miR-126* hsa-mir-126 9 20844033
hsa-miR-126* hsa-mir-126 9 18987025
hsa-miR-126* hsa-mir-126 9 18694566
hsa-miR-218 hsa-mir-218-1 4 20844033
hsa-miR-218 hsa-mir-218-2 5 20844033
hsa-miR-410 hsa-mir-410 14 20844033
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018