Annotation Detail for DCTD

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Basic Information Top

Gene Symbol:	DCTD ( MGC111062 )
Gene Full Name:	dCMP deaminase
Band:	4q35.1
Quick Links	Entrez ID:1635; OMIM: 607638; Uniprot ID:DCTD_HUMAN; ENSEMBL ID: ENSG00000129187; HGNC ID: 2710
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:2 results

Location(AA)	Modification
79	Phosphotyrosine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001921
Location:chr4 184048238-184075623
strand:-

Upstream the gene:15 results
Downstream the gene:5 results
Inside the gene:16 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	T30-glioblastoma	GSE21026	184087182	184087919	737	11927
CTCF	CD4	GSE12889	184076059	184076251	192	532
CTCF	CD4	SISSRdata	184076059	184076251	192	532
CTCF	Jurkat	GSE12889	184083494	184083733	239	7990
CTCF	G2	GSE9613	184083361	184083668	307	7891
H3K4me3	colorectal	cancer	184076186	184076600	414	770
Myc	K562	GSE19551	184083432	184083794	362	7990
P300	T30-glioblastoma	GSE21026	184087317	184088234	917	12152
Rb	Growing	GSE19898	184087892	184088129	237	12387
STAT1	IFN	SISSRdata	184083280	184083936	656	7985
TFAP2C	MCF7	GSE21234	184075847	184076493	646	547
hScc1	Bcell	GSE12603	184083394	184083706	312	7927
hScc1	Bcell	GSE12603	184084720	184084857	137	9165
hScc1	CdLS	GSE12603	184083326	184083966	640	8023
p130	shRbQuiescent	GSE19898	184087284	184088015	731	12026

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	184033738	184033941	203	14399
CTCF	G2	GSE9613	184038108	184038740	632	9815
H3ac	HepG2	E	184037896	184039231	1335	9675
USF2	HepG2	E	184037337	184037592	255	10774
hScc1	Bcell	GSE12603	184033738	184034500	762	14120

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	184053041	184053217	176	0
CTCF	G2	GSE9613	184061313	184061670	357	0
CTCF	G2	GSE9613	184072466	184072731	265	0
CTCF	G2	GSE9613	184074558	184076016	1458	0
H3K4me3	colorectal	cancer	184075281	184075702	421	0
H3ac	HepG2	E	184070919	184071524	605	0
H3ac	HepG2	E	184073212	184075013	1801	0
PHF8	Hs68minusFBS	GSE20725	184074524	184076663	2139	0
PHF8	Hs68plusFBS	GSE20725	184074469	184076766	2297	0
Rb	Growing	GSE19898	184074958	184075131	173	0
Rb	Senescent	GSE19898	184074674	184074848	174	0
hScc1	Bcell	GSE12603	184061313	184061634	321	0
hScc1	Bcell	GSE12603	184075045	184075947	902	0
hScc1	G2	GSE9613	184074487	184075977	1490	0
p130	Quiescent	GSE19898	184074921	184075221	300	0
p130	shRbQuiescent	GSE19898	184074631	184075182	551	0

Validated miRNA targets

miR Walk:7 results
Tarbase V5.0:1 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
344	Unknown	MicroArray	miR-124	DCTD	n_a	15685193
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000129187		G1-to-S transition	n_a	n_a	"epithelium, squamous cell, lymphocyte, macrophage, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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