AutismKB 2.0

Annotation Detail for DCX


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Basic Information Top
Gene Symbol:DCX ( DBCN,DC,FLJ51296,LISX,SCLH,XLIS )
Gene Full Name: doublecortin
Band: Xq23
Quick LinksEntrez ID:1641; OMIM: 300121; Uniprot ID:DCX_HUMAN; ENSEMBL ID: ENSG00000077279; HGNC ID: 2714
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
95Phosphothreonine; by PKC (Potential).
151Phosphotyrosine; by ABL (Potential).
155Phosphoserine; by PKC (Potential).
171Phosphoserine; by CK2 (Potential).
191Phosphoserine; by PKC (Potential).
196Phosphoserine; by CK2 (Potential).
346Phosphoserine; by CK2 (Potential).
375Phosphoserine; by PKC (Potential).
385Phosphoserine (By similarity).
387Phosphoserine; by CK2 (Potential).
398Phosphoserine (By similarity).
402Phosphothreonine; by PKC and MAPK
408Phosphoserine; by MAPK (Potential).
411Phosphoserine.
412Phosphothreonine; by MAPK (Potential).
415Phosphoserine; by MAPK (Potential).
418Phosphoserine; by PKC (Potential).
430Phosphoserine; by CK2 (Potential).
436Phosphoserine; by CK2 (Potential).
Location(AA) Modifications Resource
56Phosphothreonine (by PKC) (Potential).Swiss-Prot 53.0
89PhosphoserinePhospho.ELM 6.0
112Phosphotyrosine (Abl)Phospho.ELM 6.0
112Phosphotyrosine (by ABL) (Potential).Swiss-Prot 53.0
116Phosphoserine (by PKC) (Potential).Swiss-Prot 53.0
132Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
152Phosphoserine (by PKC) (Potential).Swiss-Prot 53.0
157Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
307Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
336Phosphoserine (by PKC) (Potential).Swiss-Prot 53.0
339PhosphoserinePhospho.ELM 6.0
346Phosphoserine (By similarity).Swiss-Prot 53.0
348Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
359Phosphoserine (By similarity).Swiss-Prot 53.0
363Phosphothreonine (by PKC and MAPK)(Potential).Swiss-Prot 53.0
369Phosphoserine (by MAPK) (Potential).Swiss-Prot 53.0
372Phosphoserine.Swiss-Prot 53.0
372PhosphoserinePhospho.ELM 6.0
373Phosphothreonine (by MAPK) (Potential).Swiss-Prot 53.0
376Phosphoserine (by MAPK) (Potential).Swiss-Prot 53.0
379Phosphoserine (by PKC) (Potential).Swiss-Prot 53.0
391Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
397Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
70Phosphoserine(CDK)HMM predict
70Phosphoserine(CDC2)HMM predict
167Phosphotyrosine(INSR)HMM predict
167Phosphotyrosine(EGFR)HMM predict
203Phosphoserine(IKK)HMM predict
207Phosphoserine(IKK)HMM predict
307Phosphoserine(CK1)HMM predict
319N-linkedHMM predict
323O-linkedHMM predict
329O-linkedHMM predict
329Phosphoserine(CDC2)HMM predict
331Phosphothreonine(CDK)HMM predict
331Phosphothreonine(CDC2)HMM predict
331Phosphothreonine(MAPK)HMM predict
335O-linkedHMM predict
335O-linkedHMM predict
336O-linkedHMM predict
336Phosphoserine(IKK)HMM predict
339Phosphoserine(CDC2)HMM predict
346Phosphoserine(PKG)HMM predict
346Phosphoserine(PKA)HMM predict
348Phosphoserine(PKB)HMM predict
348Phosphoserine(CDC2)HMM predict
348Phosphoserine(IKK)HMM predict
354N-linkedHMM predict
356O-linkedHMM predict
359Phosphoserine(ATM)HMM predict
359Phosphoserine(IKK)HMM predict
363O-linkedHMM predict
363Phosphothreonine(MAPK)HMM predict
366Phosphoserine(CDK)HMM predict
372O-linkedHMM predict
373Phosphothreonine(CDK)HMM predict
373O-linkedHMM predict
375O-linkedHMM predict
376Phosphoserine(MAPK)HMM predict
376PhosphoserineHMM predict
376Phosphoserine(IKK)HMM predict
376Phosphoserine(CDK)HMM predict
376Phosphoserine(CDC2)HMM predict
387Phosphotyrosine(Jak)HMM predict
397PhosphoserineHMM predict
397Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000555
  • Location:chrX 110423663-110541029
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF JurkatGSE13047 110505430 110506198 768 0
NRSF mAbJurkat 110501854 110504200 2346 0
NRSF mAbJurkat 110505333 110506443 1110 0
NRSF mAbJurkat 110506871 110508033 1162 0
NRSF mAbJurkat 110508341 110508615 274 0
NRSF mAbJurkat 110537270 110538197 927 0
NRSF mAbJurkat 110538596 110539110 514 0
NRSF-mono JurkatQuESTdata 110505595 110506128 533 0
NRSF-mono JurkatQuESTdata 110537933 110538175 242 0
NRSF-poly JurkatQuESTdata 110505508 110506090 582 0
NRSF-poly JurkatQuESTdata 110537886 110538112 226 0
PAX3-FKHR Rh4GSE19063 110478929 110479685 756 0
PAX3-FKHR Rh4GSE19063 110491232 110492084 852 0
RARA MCF7GSE15244 110532039 110532474 435 0
RARG MCF7GSE15244 110531926 110532436 510 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-128 hsa-mir-128-1 2 19713529
hsa-miR-128 hsa-mir-128-2 3 19713529
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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