AutismKB 2.0

Annotation Detail for DDX5


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Basic Information Top
Gene Symbol:DDX5 ( DKFZp434E109,DKFZp686J01190,G17P1,HLR1,HUMP68,p68 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Band: 17q23.3
Quick LinksEntrez ID:1655; OMIM: 180630; Uniprot ID:DDX5_HUMAN; ENSEMBL ID: ENSG00000108654; HGNC ID: 2746
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
6Phosphoserine.
30Phosphoserine.
32N6-acetyllysine.
33N6-acetyllysine.
40N6-acetyllysine.
122Q motif.
202Phosphotyrosine.
251DEAD box.
297Phosphotyrosine.
480Phosphoserine.
502Omega-N-methylated arginine.
507Phosphothreonine.
520Phosphoserine.
Location(AA) Modifications Resource
244PhosphotyrosinePhospho.ELM 6.0
297Phosphotyrosine.Swiss-Prot 53.0
502Omega-N-methylated arginine.Swiss-Prot 53.0
557Phosphoserine (PKC
Location(AA) Modification Resource
10MethylarginineHMM predict
14MethylarginineHMM predict
25MethylarginineHMM predict
59Phosphotyrosine(Syk)HMM predict
59Phosphotyrosine(EGFR)HMM predict
75Phosphothreonine(PKC)HMM predict
113N-linkedHMM predict
275Phosphothreonine(PKC)HMM predict
338Phosphoserine(CK1)HMM predict
342N-linkedHMM predict
420N-linkedHMM predict
425Phosphotyrosine(INSR)HMM predict
484MethylarginineHMM predict
486MethylarginineHMM predict
502MethylarginineHMM predict
514Phosphotyrosine(INSR)HMM predict
535Phosphotyrosine(SRC)HMM predict
539N-linkedHMM predict
540Phosphotyrosine(INSR)HMM predict
542N-linkedHMM predict
548N-linkedHMM predict
562N-linkedHMM predict
571Phosphotyrosine(INSR)HMM predict
571Phosphotyrosine(Syk)HMM predict
593Phosphotyrosine(Abl)HMM predict
606TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004396
  • Location:chr17 59926201-59932868
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM12892GSE19485 59931556 59934674 3118 247
Pol2 GM12878GSE19551 59931517 59934385 2868 83
USF1 HepG2E 59932512 59933932 1420 354
USF2 HepG2E 59932512 59933597 1085 186
hScc1 BcellGSE12603 59932970 59933150 180 192
p130 QuiescentGSE19898 59932086 59933760 1674 55
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 59924789 59925392 603 1111
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 59932169 59933062 893 0
H3K4me2 HCT116GSE10453 59931129 59931965 836 0
H3K4me3 colorectalcancer 59930772 59932053 1281 0
H3K4me3 colorectalcancer 59932351 59933372 1021 0
H3ac HepG2E 59930546 59932910 2364 0
PolII HeLaGSE12783 59922531 59935157 12626 0
RARA MCF7GSE15244 59931097 59932053 956 0
RARG MCF7GSE15244 59931240 59931965 725 0
TAF HelaGSE8489 59930371 59932091 1720 0
TAF k562GSE8489 59930233 59932799 2566 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-143 hsa-mir-143 5 19626115
hsa-miR-143* hsa-mir-143 5 19626115
hsa-miR-145 hsa-mir-145 5 19626115
hsa-miR-145* hsa-mir-145 5 19626115
hsa-miR-16 hsa-mir-16-1 13 19626115
hsa-miR-16 hsa-mir-16-2 3 19626115
hsa-miR-16-1* hsa-mir-16-1 13 19626115
hsa-miR-205 hsa-mir-205 1 20065103
hsa-miR-21 hsa-mir-21 17 18548003
hsa-miR-21* hsa-mir-21 17 18548003
hsa-miR-224 hsa-mir-224 X 20065103
hsa-miR-335 hsa-mir-335 7 20065103
hsa-miR-335* hsa-mir-335 7 20065103
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
hsa-miR-424 hsa-mir-424 X 20065103
hsa-miR-424* hsa-mir-424 X 20065103
hsa-miR-451 hsa-mir-451 17 20065103
hsa-miR-491-3p hsa-mir-491 9 20065103
hsa-miR-491-5p hsa-mir-491 9 20065103
hsa-miR-93 hsa-mir-93 7 20065103
hsa-miR-93* hsa-mir-93 7 20065103
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
119 Unknown MicroArray miR-1 DDX5 n_a 15685193
1150 Unknown pSILAC miR-1 DDX5 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000108654 "cardiac and skeletal muscles, cardiogenesis" n_a n_a "epithelium, lymphoblast, lymphocyte, leukocyte, macrophage" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000108654 n_a n_a n_a "epithelium, lymphoblast, lymphocyte, leukocyte, macrophage" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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