AutismKB 2.0

Annotation Detail for DLG4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DLG4 ( FLJ97752,FLJ98574,PSD95,SAP-90,SAP90 )
Gene Full Name: discs, large homolog 4 (Drosophila)
Band: 17p13.1
Quick LinksEntrez ID:1742; OMIM: 602887; Uniprot ID:DLG4_HUMAN; ENSEMBL ID: ENSG00000132535; HGNC ID: 2903
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
142Phosphoserine (By similarity).
240Phosphotyrosine (By similarity).
295Phosphoserine (By similarity).
397Phosphotyrosine (By similarity).
415Phosphoserine (By similarity).
418Phosphoserine (By similarity).
432Phosphotyrosine (By similarity).
580Phosphotyrosine (By similarity).
604Phosphotyrosine (By similarity).
701Phosphotyrosine.
715Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
3S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
5S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
142Phosphoserine (By similarity).Swiss-Prot 53.0
240Phosphotyrosine (By similarity).Swiss-Prot 53.0
295Phosphoserine (By similarity).Swiss-Prot 53.0
415Phosphoserine (By similarity).Swiss-Prot 53.0
418Phosphoserine (By similarity).Swiss-Prot 53.0
432Phosphotyrosine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
19Phosphothreonine(MAPK)HMM predict
35Phosphoserine(CDC2)HMM predict
55N-linkedHMM predict
63Phosphotyrosine(EGFR)HMM predict
63Phosphotyrosine(Syk)HMM predict
63Phosphotyrosine(SRC)HMM predict
165O-linkedHMM predict
190Phosphotyrosine(EGFR)HMM predict
236Phosphotyrosine(Syk)HMM predict
240Phosphotyrosine(Syk)HMM predict
250Phosphotyrosine(Syk)HMM predict
255Phosphotyrosine(Syk)HMM predict
265Phosphoserine(ATM)HMM predict
282SulfotyrosineHMM predict
287Phosphothreonine(CDC2)HMM predict
287Phosphothreonine(MAPK)HMM predict
287Phosphothreonine(CDK)HMM predict
397Phosphotyrosine(EGFR)HMM predict
418Phosphoserine(IKK)HMM predict
439SulfotyrosineHMM predict
513Phosphoserine(ATM)HMM predict
604Phosphotyrosine(Abl)HMM predict
609Phosphotyrosine(Abl)HMM predict
666Phosphothreonine(CK2)HMM predict
721ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001365
  • Location:chr17 7033935-7063744
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 7063152 7064438 1286 51
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 7030466 7030675 209 3365
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 7058116 7059124 1008 0
ETS1 JurkatGSE17954 7035295 7036121 826 0
ETS1 JurkatGSE17954 7058331 7059741 1410 0
Fos K562GSE19551 7035573 7035947 374 0
H3ac HepG2E 7063341 7063736 395 0
NFkBII GM18526GSE19485 7048670 7049898 1228 0
NRSF JurkatGSE13047 7035539 7036218 679 0
NRSF mAbJurkat 7036025 7037185 1160 0
NRSF-mono JurkatQuESTdata 7035544 7036326 782 0
NRSF-poly JurkatQuESTdata 7035615 7036317 702 0
Rb GrowingGSE19898 7058414 7058593 179 0
Rb GrowingGSE19898 7058656 7058977 321 0
Rb QuiescentGSE19898 7049048 7049175 127 0
Rb QuiescentGSE19898 7057845 7058628 783 0
Rb QuiescentGSE19898 7058668 7058938 270 0
Rb SenescentGSE19898 7057939 7058260 321 0
Rb SenescentGSE19898 7058286 7059203 917 0
Rb shRbQuiescentGSE19898 7058383 7058576 193 0
hScc1 BcellGSE12603 7058268 7058914 646 0
p130 QuiescentGSE19898 7049007 7049336 329 0
p130 QuiescentGSE19898 7049438 7049589 151 0
p130 QuiescentGSE19898 7058143 7058659 516 0
p130 SenescentGSE19898 7058220 7058970 750 0
p130 shRbQuiescentGSE19898 7048833 7049398 565 0
p130 shRbQuiescentGSE19898 7058172 7058838 666 0
p130 shRbSenescentGSE19898 7048899 7049452 553 0
p130 shRbSenescentGSE19898 7058233 7058572 339 0
p130 shRbSenescentGSE19898 7058678 7059272 594 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-375 hsa-mir-375 2 20584986
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018