AutismKB 2.0

Annotation Detail for DNM2


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Basic Information Top
Gene Symbol:DNM2 ( CMT2M,CMTDI1,CMTDIB,DI-CMTB,DYN2,DYNII )
Gene Full Name: dynamin 2
Band: 19p13.2
Quick LinksEntrez ID:1785; OMIM: 602378; Uniprot ID:DYN2_HUMAN; ENSEMBL ID: ENSG00000079805; HGNC ID: 2974
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
298Phosphoserine (By similarity).
302Phosphoserine (By similarity).
449Phosphotyrosine.
597Phosphotyrosine (By similarity).
598N6-acetyllysine.
766Phosphothreonine.
Location(AA) Modifications Resource
762PhosphoserinePhospho.ELM 6.0
766Phosphothreonine.Swiss-Prot 53.0
Location(AA) Modification Resource
21Phosphoserine(CK1)HMM predict
65Phosphothreonine(PKC)HMM predict
76Phosphoserine(CK1)HMM predict
116Phosphoserine(CDC2)HMM predict
131N-linkedHMM predict
169Phosphoserine(CK1)HMM predict
175Phosphothreonine(CDC2)HMM predict
236N-linkedHMM predict
302Phosphoserine(IKK)HMM predict
314PhosphotyrosineHMM predict
326Phosphothreonine(PKA)HMM predict
444Phosphoserine(IKK)HMM predict
563Phosphotyrosine(INSR)HMM predict
685N-linkedHMM predict
686N-linkedHMM predict
742O-linkedHMM predict
742O-linkedHMM predict
743O-linkedHMM predict
745O-linkedHMM predict
745O-linkedHMM predict
746O-linkedHMM predict
746Phosphothreonine(CDK)HMM predict
764Phosphoserine(IKK)HMM predict
764Phosphoserine(MAPK)HMM predict
766Phosphothreonine(CDC2)HMM predict
766Phosphothreonine(CDK)HMM predict
766Phosphothreonine(MAPK)HMM predict
773O-linkedHMM predict
788Phosphothreonine(MAPK)HMM predict
803Phosphoserine(IKK)HMM predict
805O-linkedHMM predict
811O-linkedHMM predict
848O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001005360
  • Location:chr19 10689754-10803578
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 10689002 10689597 595 455
CTCF CD4SISSRdata 10689002 10689597 595 455
CTCF HelaGSE12889 10689016 10689294 278 600
CTCF G2GSE9613 10688883 10689281 398 673
ETS1 JurkatGSE17954 10688842 10690661 1819 3
GABP k562GSE8489 10688883 10689609 726 509
LIN9 SGSE7516 10689210 10689818 608 241
P300 T0-glioblastomaGSE21026 10688870 10690085 1215 277
P300 T30-glioblastomaGSE21026 10688769 10690179 1410 281
hScc1 BcellGSE12603 10688883 10690046 1163 290
hScc1 CdLSGSE12603 10688883 10689381 498 623
p130 shRbQuiescentGSE19898 10688850 10689394 544 633
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 10730683 10732399 1716 0
CTCF CD4GSE12889 10703342 10703552 210 0
CTCF CD4SISSRdata 10703342 10703552 210 0
CTCF G2GSE9613 10781826 10782106 280 0
ER E2-MCF7GSE14664 10761480 10761519 39 0
ER E2-MCF7GSE14664 10777455 10777546 91 0
ER Fulvestrant-MCF7GSE14664 10761481 10761526 45 0
Fos K562GSE19551 10720445 10721187 742 0
FoxA1 MCF7MACSdata 10712616 10712765 149 0
FoxA1 MCF7MACSdata 10745711 10745958 247 0
Oct1 H2O2-HelaGSE14283 10699503 10699550 47 0
Oct1 H2O2-HelaGSE14283 10736923 10736959 36 0
Oct1 HelaGSE14283 10699503 10699532 29 0
Oct1 HelaGSE14283 10736893 10736960 67 0
Oct1 HelaGSE14283 10761472 10761530 58 0
Oct1 HelaGSE14283 10802578 10802614 36 0
P300 T30-glioblastomaGSE21026 10788659 10789862 1203 0
PHF8 HeLaGSE20725 10689437 10690419 982 0
Rb SenescentGSE19898 10789081 10789770 689 0
Rb shRbQuiescentGSE19898 10737191 10737439 248 0
Rb shRbSenescenceGSE19898 10789449 10789763 314 0
TAF HelaGSE8489 10713720 10713967 247 0
TFAP2C MCF7GSE21234 10696132 10696603 471 0
TFAP2C MCF7GSE21234 10715516 10716571 1055 0
TFAP2C MCF7GSE21234 10720253 10721277 1024 0
TFAP2C MCF7GSE21234 10733996 10734895 899 0
TFAP2C MCF7GSE21234 10741637 10742190 553 0
TFAP2C MCF7GSE21234 10789894 10790513 619 0
TFAP2C MCF7GSE21234 10792490 10793185 695 0
USF1 HepG2E 10719093 10721168 2075 0
hScc1 BcellGSE12603 10728301 10729021 720 0
hScc1 BcellGSE12603 10731363 10731672 309 0
hScc1 BcellGSE12603 10736400 10736592 192 0
hScc1 BcellGSE12603 10783347 10783491 144 0
p130 SenescentGSE19898 10784512 10785010 498 0
p130 SenescentGSE19898 10788594 10789806 1212 0
p130 shRbQuiescentGSE19898 10788509 10789979 1470 0
p130 shRbSenescentGSE19898 10789005 10789642 637 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
321 Unknown MicroArray miR-124 DNM2 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000079805 G1-to-S transition n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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