AutismKB 2.0

Annotation Detail for DNMT1


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Basic Information Top
Gene Symbol:DNMT1 ( AIM,CXXC9,DNMT,FLJ16293,MCMT,MGC104992 )
Gene Full Name: DNA (cytosine-5-)-methyltransferase 1
Band: 19p13.2
Quick LinksEntrez ID:1786; OMIM: 126375; Uniprot ID:DNMT1_HUMAN; ENSEMBL ID: ENSG00000130816; HGNC ID: 2976
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
70N6,N6-dimethyllysine.
127Phosphoserine.
137Phosphothreonine.
152Phosphoserine.
154Phosphoserine.
173N6-acetyllysine.
205Nuclear localization signal (Potential).
288Phosphoserine (By similarity).
394Phosphoserine.
509Phosphoserine (By similarity).
714Phosphoserine.
732Phosphoserine.
954Phosphoserine.
969Phosphotyrosine.
1105Phosphoserine.
1113N6-acetyllysine.
1115N6-acetyllysine.
1117N6-acetyllysine; by EHMT2.
Location(AA) Modifications Resource
127Phosphoserine.Swiss-Prot 53.0
127PhosphoserinePhospho.ELM 6.0
509Phosphoserine (By similarity).Swiss-Prot 53.0
714Phosphoserine.Swiss-Prot 53.0
714PhosphoserinePhospho.ELM 6.0
954Phosphoserine.Swiss-Prot 53.0
954PhosphoserinePhospho.ELM 6.0
1105PhosphoserinePhospho.ELM 6.0
1105Phosphoserine.Swiss-Prot 53.0
1113N6-acetyllysine.Swiss-Prot 53.0
1115N6-acetyllysine.Swiss-Prot 53.0
1117N6-acetyllysine.Swiss-Prot 53.0
Location(AA) Modification Resource
35Phosphoserine(CK1)HMM predict
74Phosphoserine(CK2)HMM predict
74Phosphoserine(CK1)HMM predict
91Phosphoserine(CK1)HMM predict
127Phosphoserine(CDC2)HMM predict
127Phosphoserine(CDK)HMM predict
137Phosphothreonine(CDC2)HMM predict
137Phosphothreonine(CDK)HMM predict
137Phosphothreonine(PKC)HMM predict
137Phosphothreonine(MAPK)HMM predict
141Phosphoserine(PKA)HMM predict
143Phosphoserine(PKB)HMM predict
143Phosphoserine(PKA)HMM predict
152O-linkedHMM predict
154Phosphoserine(ATM)HMM predict
154Phosphoserine(CDC2)HMM predict
158O-linkedHMM predict
165Phosphothreonine(PKA)HMM predict
184Phosphoserine(CK2)HMM predict
189Phosphoserine(CK2)HMM predict
189Phosphoserine(CK1)HMM predict
192Phosphoserine(CK2)HMM predict
208Phosphothreonine(PKC)HMM predict
208Phosphothreonine(PKA)HMM predict
227Phosphoserine(IKK)HMM predict
229Phosphothreonine(PKC)HMM predict
247Phosphoserine(PKG)HMM predict
253Phosphothreonine(MAPK)HMM predict
288Phosphoserine(ATM)HMM predict
327Phosphothreonine(PKA)HMM predict
327Phosphothreonine(PKC)HMM predict
328Phosphothreonine(PKA)HMM predict
342Phosphothreonine(PKC)HMM predict
367SulfotyrosineHMM predict
392N-linkedHMM predict
399Phosphotyrosine(Syk)HMM predict
399Phosphotyrosine(EGFR)HMM predict
448Phosphoserine(CK1)HMM predict
486SulfotyrosineHMM predict
486Phosphotyrosine(INSR)HMM predict
507Phosphotyrosine(EGFR)HMM predict
522Phosphoserine(CK1)HMM predict
522Phosphoserine(CK2)HMM predict
524Phosphotyrosine(Syk)HMM predict
524Phosphotyrosine(INSR)HMM predict
563Phosphoserine(CK2)HMM predict
570Phosphoserine(ATM)HMM predict
603Phosphothreonine(PKA)HMM predict
603Phosphothreonine(PKC)HMM predict
714Phosphoserine(CDC2)HMM predict
771Phosphoserine(CK1)HMM predict
865SulfotyrosineHMM predict
873Phosphotyrosine(EGFR)HMM predict
873Phosphotyrosine(Syk)HMM predict
878Phosphoserine(CDC2)HMM predict
878Phosphoserine(IKK)HMM predict
940Phosphotyrosine(Jak)HMM predict
940Phosphotyrosine(Syk)HMM predict
940Phosphotyrosine(INSR)HMM predict
954Phosphoserine(CDC2)HMM predict
969Phosphotyrosine(EGFR)HMM predict
979Phosphotyrosine(INSR)HMM predict
1010N-linkedHMM predict
1095Phosphoserine(IKK)HMM predict
1105Phosphoserine(CDC2)HMM predict
1128Phosphoserine(CK2)HMM predict
1257Phosphotyrosine(Syk)HMM predict
1258Phosphotyrosine(Jak)HMM predict
1273Phosphoserine(CDK)HMM predict
1309Phosphothreonine(PKC)HMM predict
1353N-linkedHMM predict
1359Phosphoserine(PKB)HMM predict
1447Phosphoserine(PKG)HMM predict
1525O-linkedHMM predict
1526O-linkedHMM predict
1603Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001379
  • Location:chr19 10105022-10166810
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 10166558 10167142 584 40
USF1 HepG2E 10177947 10178479 532 11403
USF2 HepG2E 10166604 10167130 526 57
p130 SenescentGSE19898 10177969 10178310 341 11329
p63 keratinocytesGSE17611 10172568 10173287 719 6117
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 10136591 10136802 211 0
GABP k562GSE8489 10147128 10147413 285 0
GABP k562GSE8489 10165375 10166067 692 0
H3K4me2 HCT116GSE10453 10165375 10165806 431 0
H3ac HepG2E 10165375 10166028 653 0
HIF1 NormHepG2 10166209 10166703 494 0
NRSF mAbJurkat 10165375 10166067 692 0
Oct1 HelaGSE14283 10118082 10118143 61 0
Oct1 HelaGSE14283 10120300 10120340 40 0
Oct1 HelaGSE14283 10135329 10135358 29 0
P300 T30-glioblastomaGSE21026 10136371 10136776 405 0
PHF8 293TGSE20725 10166116 10167145 1029 0
PHF8 HeLaGSE20725 10165515 10167136 1621 0
Rb GrowingGSE19898 10166440 10166782 342 0
Rb QuiescentGSE19898 10165951 10166530 579 0
Rb QuiescentGSE19898 10166550 10166732 182 0
Rb SenescentGSE19898 10165420 10167078 1658 0
Rb shRbQuiescentGSE19898 10166571 10166823 252 0
Rb shRbSenescenceGSE19898 10166015 10166765 750 0
SRF k562GSE8489 10147128 10147413 285 0
TAF HelaGSE8489 10165375 10165918 543 0
TAF k562GSE8489 10147128 10147413 285 0
TAF k562GSE8489 10165375 10165880 505 0
TFAP2C MCF7GSE21234 10156191 10156904 713 0
hScc1 BcellGSE12603 10110918 10111543 625 0
hScc1 BcellGSE12603 10116119 10116401 282 0
hScc1 BcellGSE12603 10131190 10131473 283 0
hScc1 BcellGSE12603 10166209 10166747 538 0
hScc1 CdLSGSE12603 10166172 10166633 461 0
p130 QuiescentGSE19898 10166063 10166899 836 0
p130 SenescentGSE19898 10166416 10167053 637 0
p130 shRbQuiescentGSE19898 10166072 10167030 958 0
p130 shRbSenescentGSE19898 10165465 10167058 1593 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 17308078
hsa-let-7a hsa-let-7a-2 11 17308078
hsa-let-7a hsa-let-7a-3 22 17308078
hsa-let-7a* hsa-let-7a-3 22 17308078
hsa-let-7a* hsa-let-7a-1 9 17308078
hsa-let-7b hsa-let-7b 22 17308078
hsa-let-7b* hsa-let-7b 22 17308078
hsa-let-7c hsa-let-7c 21 17308078
hsa-let-7c* hsa-let-7c 21 17308078
hsa-let-7d hsa-let-7d 9 17308078
hsa-let-7d* hsa-let-7d 9 17308078
hsa-let-7e hsa-let-7e 19 17308078
hsa-let-7e* hsa-let-7e 19 17308078
hsa-let-7f hsa-let-7f-1 9 17308078
hsa-let-7f hsa-let-7f-2 X 17308078
hsa-let-7f-1* hsa-let-7f-1 9 17308078
hsa-let-7f-2* hsa-let-7f-2 X 17308078
hsa-let-7g hsa-let-7g 3 17308078
hsa-let-7g* hsa-let-7g 3 17308078
hsa-let-7i hsa-let-7i 12 17308078
hsa-let-7i* hsa-let-7i 12 17308078
hsa-miR-1 hsa-mir-1-2 18 18593903
hsa-miR-1 hsa-mir-1-1 20 18593903
hsa-miR-10a hsa-mir-10a 17 21269386
hsa-miR-10a hsa-mir-10a 17 17660710
hsa-miR-10a* hsa-mir-10a 17 21269386
hsa-miR-10a* hsa-mir-10a 17 17660710
hsa-miR-122 hsa-mir-122 18 21269386
hsa-miR-122* hsa-mir-122 18 21269386
hsa-miR-126 hsa-mir-126 9 21165896
hsa-miR-126* hsa-mir-126 9 21165896
hsa-miR-128 hsa-mir-128-1 2 21372826
hsa-miR-128 hsa-mir-128-2 3 21372826
hsa-miR-137 hsa-mir-137 1 21221794
hsa-miR-148a hsa-mir-148a 7 21358093
hsa-miR-148a hsa-mir-148a 7 20483747
hsa-miR-148a hsa-mir-148a 7 18314617
hsa-miR-148a* hsa-mir-148a 7 21358093
hsa-miR-148a* hsa-mir-148a 7 20483747
hsa-miR-148a* hsa-mir-148a 7 18314617
hsa-miR-148b hsa-mir-148b 12 18314617
hsa-miR-148b* hsa-mir-148b 12 18314617
hsa-miR-152 hsa-mir-152 17 21116279
hsa-miR-152 hsa-mir-152 17 20841484
hsa-miR-152 hsa-mir-152 17 20578129
hsa-miR-152 hsa-mir-152 17 18314617
hsa-miR-155 hsa-mir-155 21 20966899
hsa-miR-155* hsa-mir-155 21 20966899
hsa-miR-193a-3p hsa-mir-193a 17 21358093
hsa-miR-193a-5p hsa-mir-193a 17 21358093
hsa-miR-196a hsa-mir-196a-1 17 21315047
hsa-miR-196a hsa-mir-196a-2 12 21315047
hsa-miR-205 hsa-mir-205 1 21269386
hsa-miR-21 hsa-mir-21 17 21269386
hsa-miR-21 hsa-mir-21 17 20483747
hsa-miR-21* hsa-mir-21 17 21269386
hsa-miR-21* hsa-mir-21 17 20483747
hsa-miR-221 hsa-mir-221 X 21278784
hsa-miR-221* hsa-mir-221 X 21278784
hsa-miR-224 hsa-mir-224 X 21358093
hsa-miR-27b hsa-mir-27b 9 20495621
hsa-miR-27b* hsa-mir-27b 9 20495621
hsa-miR-29a hsa-mir-29a 7 17890317
hsa-miR-29a* hsa-mir-29a 7 17890317
hsa-miR-29b hsa-mir-29b-1 7 19211935
hsa-miR-29b hsa-mir-29b-2 1 19211935
hsa-miR-29b hsa-mir-29b-1 7 17890317
hsa-miR-29b hsa-mir-29b-2 1 17890317
hsa-miR-29b-1* hsa-mir-29b-1 7 19211935
hsa-miR-29b-1* hsa-mir-29b-1 7 17890317
hsa-miR-29b-2* hsa-mir-29b-2 1 17890317
hsa-miR-29c hsa-mir-29c 1 17890317
hsa-miR-29c* hsa-mir-29c 1 17890317
hsa-miR-302a hsa-mir-302a 4 20495621
hsa-miR-302a hsa-mir-302a 4 20870751
hsa-miR-302a* hsa-mir-302a 4 20495621
hsa-miR-302a* hsa-mir-302a 4 20870751
hsa-miR-302b hsa-mir-302b 4 20870751
hsa-miR-302b* hsa-mir-302b 4 20870751
hsa-miR-302c hsa-mir-302c 4 20870751
hsa-miR-302c* hsa-mir-302c 4 20870751
hsa-miR-302d hsa-mir-302d 4 20870751
hsa-miR-302d* hsa-mir-302d 4 20870751
hsa-miR-302f hsa-mir-302f 0 20870751
hsa-miR-338-3p hsa-mir-338 17 19473441
hsa-miR-338-5p hsa-mir-338 17 19473441
hsa-miR-375 hsa-mir-375 2 21269386
hsa-miR-512-3p hsa-mir-512-1 19 21269386
hsa-miR-512-3p hsa-mir-512-2 19 21269386
hsa-miR-512-5p hsa-mir-512-1 19 21269386
hsa-miR-512-5p hsa-mir-512-2 19 21269386
hsa-miR-520c-3p hsa-mir-520c 19 21269386
hsa-miR-663 hsa-mir-663 20 18314617
hsa-miR-9 hsa-mir-9-1 1 18314617
hsa-miR-9* hsa-mir-9-1 1 21269386
hsa-miR-9* hsa-mir-9-2 5 21269386
hsa-miR-9* hsa-mir-9-3 15 21269386
hsa-miR-9* hsa-mir-9-1 1 18314617
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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