AutismKB 2.0

Annotation Detail for DOCK1


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Basic Information Top
Gene Symbol:DOCK1 ( DOCK180,ced5 )
Gene Full Name: dedicator of cytokinesis 1
Band: 10q26.2
Quick LinksEntrez ID:1793; OMIM: 601403; Uniprot ID:DOCK1_HUMAN; ENSEMBL ID: ENSG00000150760; HGNC ID: 2987
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1751Phosphoserine.
1756Phosphoserine (By similarity).
1805SH3-binding; interaction with CRK
1811Phosphotyrosine.
1843SH3-binding; interaction with CRK
1858Phosphoserine.
Location(AA) Modifications Resource
1858Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
13Phosphotyrosine(SRC)HMM predict
29Phosphoserine(CK1)HMM predict
55Phosphoserine(PKG)HMM predict
150Phosphothreonine(PKA)HMM predict
204Phosphoserine(CK1)HMM predict
204Phosphoserine(ATM)HMM predict
312N-linkedHMM predict
313N-linkedHMM predict
429Phosphotyrosine(EGFR)HMM predict
429Phosphotyrosine(Jak)HMM predict
505N-linkedHMM predict
518Phosphoserine(CAMK2)HMM predict
899Phosphothreonine(PKC)HMM predict
915N-linkedHMM predict
947SulfotyrosineHMM predict
1042N-linkedHMM predict
1145Phosphotyrosine(Syk)HMM predict
1232N-linkedHMM predict
1233Phosphotyrosine(INSR)HMM predict
1264Phosphotyrosine(Syk)HMM predict
1264Phosphotyrosine(EGFR)HMM predict
1277Phosphotyrosine(EGFR)HMM predict
1304SulfotyrosineHMM predict
1304Phosphotyrosine(Syk)HMM predict
1388Phosphoserine(IKK)HMM predict
1464Phosphotyrosine(INSR)HMM predict
1541Phosphotyrosine(EGFR)HMM predict
1627PhosphoserineHMM predict
1627Phosphoserine(PKA)HMM predict
1627Phosphoserine(PKC)HMM predict
1631Phosphoserine(IKK)HMM predict
1637Phosphothreonine(PKC)HMM predict
1637Phosphothreonine(PKA)HMM predict
1642O-linkedHMM predict
1646Phosphoserine(IKK)HMM predict
1652Phosphoserine(CK1)HMM predict
1654Phosphoserine(CK1)HMM predict
1654Phosphoserine(CK2)HMM predict
1655Phosphoserine(CK1)HMM predict
1658Phosphothreonine(MAPK)HMM predict
1658Phosphothreonine(CDC2)HMM predict
1658Phosphothreonine(CDK)HMM predict
1660O-linkedHMM predict
1704Phosphoserine(CK1)HMM predict
1734Phosphoserine(CDC2)HMM predict
1756Phosphoserine(PKA)HMM predict
1756Phosphoserine(PKB)HMM predict
1756Phosphoserine(PKG)HMM predict
1756O-linkedHMM predict
1758O-linkedHMM predict
1758Phosphoserine(CDK)HMM predict
1758Phosphoserine(CDC2)HMM predict
1761Phosphoserine(MAPK)HMM predict
1761Phosphoserine(CDC2)HMM predict
1764Phosphoserine(IKK)HMM predict
1764Phosphoserine(ATM)HMM predict
1767Phosphothreonine(CDC2)HMM predict
1767O-linkedHMM predict
1767Phosphothreonine(MAPK)HMM predict
1772O-linkedHMM predict
1772Phosphothreonine(MAPK)HMM predict
1772Phosphothreonine(CDC2)HMM predict
1823Phosphoserine(CDC2)HMM predict
1823O-linkedHMM predict
1825O-linkedHMM predict
1842O-linkedHMM predict
1852Phosphothreonine(PKC)HMM predict
1857Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001380
  • Location:chr10 128584012-129140768
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 128580813 128581184 371 3014
H3ac HepG2E 128581770 128583592 1822 1332
PHF8 HeLaGSE20725 128583557 128584267 710 101
RARA MCF7GSE15244 128580651 128581184 533 3095
RARG MCF7GSE15244 128580813 128581184 371 3014
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 129035633 129035856 223 0
CTCF CD4SISSRdata 129035633 129035856 223 0
CTCF JurkatGSE12889 128931871 128932059 188 0
ER Breast-CancerGSE22609 129017124 129017782 658 0
ER Breast-CancerGSE22609 129085692 129086543 851 0
ER E2-MCF7GSE14664 129068129 129068176 47 0
ER E2-MCF7GSE14664 129138448 129138490 42 0
ER MCF7GSE19013 129017067 129017713 646 0
ETS1 JurkatGSE17954 128981593 128982481 888 0
FoxA1 MCF7MACSdata 129054221 129054421 200 0
GABP HelaGSE8489 129085209 129086038 829 0
NRSF JurkatGSE13047 128805205 128806168 963 0
NRSF mAbJurkat 128803408 128804654 1246 0
NRSF mAbJurkat 128805012 128807278 2266 0
NRSF mAbJurkat 128807611 128807826 215 0
NRSF-mono JurkatQuESTdata 128805288 128805823 535 0
NRSF-mono JurkatQuESTdata 128805849 128806391 542 0
NRSF-poly JurkatQuESTdata 128805346 128806069 723 0
Nanog hESGSE18292 128968702 128969299 597 0
Oct1 H2O2-HelaGSE14283 128608223 128608251 28 0
Oct1 H2O2-HelaGSE14283 128621200 128621242 42 0
Oct1 H2O2-HelaGSE14283 128630479 128630508 29 0
Oct1 H2O2-HelaGSE14283 128634103 128634140 37 0
Oct1 H2O2-HelaGSE14283 128741488 128741535 47 0
Oct1 H2O2-HelaGSE14283 128980308 128980339 31 0
Oct1 H2O2-HelaGSE14283 129121921 129121963 42 0
Oct1 HelaGSE14283 128621208 128621241 33 0
Oct1 HelaGSE14283 128634103 128634138 35 0
Oct1 HelaGSE14283 128741487 128741535 48 0
Oct1 HelaGSE14283 128926948 128926980 32 0
Oct1 HelaGSE14283 128935955 128935987 32 0
Oct1 HelaGSE14283 128980308 128980339 31 0
Oct1 HelaGSE14283 129009363 129009399 36 0
Oct1 HelaGSE14283 129010528 129010583 55 0
Oct1 HelaGSE14283 129121921 129121964 43 0
Oct1 HelaGSE14283 129138418 129138479 61 0
Oct4 ESGSE20650 129075200 129075547 347 0
Oct4 hESGSE21916 129075132 129075609 477 0
P300 T0-glioblastomaGSE21026 129091145 129091826 681 0
RARA MCF7GSE15244 128691221 128691688 467 0
RARA MCF7GSE15244 128701140 128702821 1681 0
RARA MCF7GSE15244 129085096 129086229 1133 0
RARG MCF7GSE15244 128673789 128674068 279 0
RARG MCF7GSE15244 128691161 128691758 597 0
RARG MCF7GSE15244 128701076 128702414 1338 0
RARG MCF7GSE15244 128722768 128722992 224 0
RARG MCF7GSE15244 129085133 129086229 1096 0
RNAII Tamoxifen-MCF7GSE14664 128621206 128621241 35 0
RNAII Tamoxifen-MCF7GSE14664 129138417 129138486 69 0
Sox2 hESGSE18292 128968693 128969093 400 0
TFAP2C MCF7GSE21234 128588856 128589098 242 0
TFAP2C MCF7GSE21234 128667602 128667961 359 0
TFAP2C MCF7GSE21234 128700865 128701518 653 0
TFAP2C MCF7GSE21234 128701852 128702338 486 0
TFAP2C MCF7GSE21234 128935272 128935647 375 0
USF1 HepG2E 128966446 128968089 1643 0
USF2 HepG2E 128967728 128968056 328 0
hScc1 BcellGSE12603 128583493 128584532 1039 0
hScc1 BcellGSE12603 128585003 128585352 349 0
hScc1 BcellGSE12603 128777162 128777496 334 0
hScc1 BcellGSE12603 128884219 128885088 869 0
hScc1 BcellGSE12603 129034885 129035112 227 0
hScc1 BcellGSE12603 129108715 129108907 192 0
hScc1 CdLSGSE12603 128583632 128584775 1143 0
p63 keratinocytesGSE17611 128732187 128733235 1048 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
3830 mRNA DOCK1 chr10 128658954 129140769 73 EST chr10 128701836 128714729Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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