AutismKB 2.0

Annotation Detail for DOCK2


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Basic Information Top
Gene Symbol:DOCK2 ( FLJ46592,KIAA0209 )
Gene Full Name: dedicator of cytokinesis 2
Band: 5q35.1
Quick LinksEntrez ID:1794; OMIM: 603122; Uniprot ID:DOCK2_HUMAN; ENSEMBL ID: ENSG00000134516; HGNC ID: 2988
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
67N6-acetyllysine.
209Phosphotyrosine.
212Phosphotyrosine.
304N6-acetyllysine.
588Phosphoserine.
593Phosphoserine.
738N6-acetyllysine.
1058N6-acetyllysine.
1685Phosphoserine.
1706Phosphoserine (By similarity).
1731Phosphoserine.
Location(AA) Modifications Resource
209Phosphotyrosine.Swiss-Prot 53.0
209PhosphotyrosinePhospho.ELM 6.0
212Phosphotyrosine.Swiss-Prot 53.0
212PhosphotyrosinePhospho.ELM 6.0
1706Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
149Phosphothreonine(PKA)HMM predict
177N-linkedHMM predict
203Phosphoserine(CK1)HMM predict
209Phosphotyrosine(Syk)HMM predict
216O-linkedHMM predict
217Phosphoserine(CK1)HMM predict
218Phosphoserine(CDC2)HMM predict
218Phosphoserine(CDK)HMM predict
294Phosphotyrosine(Jak)HMM predict
340Phosphoserine(CK2)HMM predict
340PhosphoserineHMM predict
340Phosphoserine(CK2)HMM predict
427Phosphotyrosine(EGFR)HMM predict
438Phosphotyrosine(Syk)HMM predict
439N-linkedHMM predict
445N-linkedHMM predict
567Phosphothreonine(PKC)HMM predict
581Phosphothreonine(PKC)HMM predict
586Phosphoserine(CK1)HMM predict
587Phosphoserine(CK1)HMM predict
601O-linkedHMM predict
664Phosphoserine(ATM)HMM predict
669SulfotyrosineHMM predict
904Phosphothreonine(PKC)HMM predict
920N-linkedHMM predict
1149Phosphotyrosine(Syk)HMM predict
1236N-linkedHMM predict
1260Phosphoserine(IKK)HMM predict
1281Phosphotyrosine(INSR)HMM predict
1389N-linkedHMM predict
1452Phosphothreonine(PKC)HMM predict
1452Phosphothreonine(PKA)HMM predict
1493Phosphoserine(CDC2)HMM predict
1659O-linkedHMM predict
1675Phosphothreonine(MAPK)HMM predict
1685Phosphoserine(CDC2)HMM predict
1685Phosphoserine(ATM)HMM predict
1685O-linkedHMM predict
1685Phosphoserine(MAPK)HMM predict
1698Phosphoserine(PKA)HMM predict
1702Phosphothreonine(PKC)HMM predict
1702Phosphothreonine(PKA)HMM predict
1705Phosphoserine(PKG)HMM predict
1736Phosphoserine(CK2)HMM predict
1746Phosphoserine(IKK)HMM predict
1752Phosphoserine(IKK)HMM predict
1778N-linkedHMM predict
1779Phosphothreonine(PKC)HMM predict
1780PhosphoserineHMM predict
1799Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004946
  • Location:chr5 168996870-169442958
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 SenescentGSE19898 168986408 168986603 195 10365
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 169452248 169452535 287 9433
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 169213148 169213436 288 0
CTCF CD4GSE12889 169340268 169340448 180 0
CTCF CD4SISSRdata 169340268 169340448 180 0
CTCF G2GSE9613 168996807 168997068 261 0
CTCF G2GSE9613 169003282 169003496 214 0
CTCF G2GSE9613 169035138 169035489 351 0
CTCF G2GSE9613 169061411 169061711 300 0
CTCF G2GSE9613 169115379 169115707 328 0
CTCF G2GSE9613 169139123 169139358 235 0
CTCF G2GSE9613 169172380 169172662 282 0
CTCF G2GSE9613 169198039 169198218 179 0
CTCF G2GSE9613 169303849 169304121 272 0
CTCF G2GSE9613 169305592 169305746 154 0
CTCF G2GSE9613 169339842 169340739 897 0
CTCF G2GSE9613 169351118 169351288 170 0
CTCF G2GSE9613 169401308 169401708 400 0
CTCF G2GSE9613 169411443 169411690 247 0
CTCF G2GSE9613 169430299 169430860 561 0
CTCF G2GSE9613 169439845 169440025 180 0
FOXA1 MCF7GSE15244 169293079 169295204 2125 0
FOXA1 MCF7GSE15244 169304862 169306374 1512 0
FOXA1 MCF7GSE15244 169377138 169378021 883 0
FOXA1 MCF7GSE15244 169415920 169417290 1370 0
GABP k562GSE8489 169131599 169131852 253 0
Gata2 K562GSE18868 169105695 169106328 633 0
KLF4 hESGSE17917 169253188 169253554 366 0
Myc hESGSE17917 169336299 169336561 262 0
NFkBII GM12878GSE19485 169008753 169011403 2650 0
NRSF JurkatGSE13047 169000684 169001252 568 0
NRSF JurkatGSE13047 169274351 169274843 492 0
NRSF JurkatSISSRdata 169000812 169001181 369 0
NRSF mAbJurkat 168998024 168998641 617 0
NRSF mAbJurkat 169001322 169001903 581 0
NRSF mAbJurkat 169186796 169187884 1088 0
NRSF mAbJurkat 169274437 169274844 407 0
NRSF mAbJurkat 169275229 169276015 786 0
NRSF-mono JurkatQuESTdata 169000683 169001222 539 0
NRSF-mono JurkatQuESTdata 169187392 169187837 445 0
NRSF-mono JurkatQuESTdata 169274350 169274836 486 0
NRSF-poly JurkatQuESTdata 169187423 169187753 330 0
NRSF-poly JurkatQuESTdata 169274334 169274795 461 0
Nanog hESGSE18292 169339215 169339794 579 0
P300 T30-glioblastomaGSE21026 169010304 169011186 882 0
P300 T30-glioblastomaGSE21026 169055231 169057209 1978 0
P300 T30-glioblastomaGSE21026 169076487 169077461 974 0
TAF HelaGSE8489 169008982 169009160 178 0
TAF HelaGSE8489 169131599 169131743 144 0
TFAP2C MCF7GSE21234 169057595 169058028 433 0
TFAP2C MCF7GSE21234 169305021 169305767 746 0
TFAP2C MCF7GSE21234 169416230 169417241 1011 0
hScc1 BcellGSE12603 168996922 168997068 146 0
hScc1 BcellGSE12603 169204608 169204994 386 0
hScc1 BcellGSE12603 169339869 169340555 686 0
hScc1 CdLSGSE12603 169302666 169302921 255 0
hScc1 CdLSGSE12603 169340028 169340459 431 0
hScc1 G2GSE9613 169061411 169061889 478 0
hScc1 G2GSE9613 169430228 169430931 703 0
p130 SenescentGSE19898 169221678 169221966 288 0
p130 shRbQuiescentGSE19898 169305330 169306140 810 0
p130 shRbSenescentGSE19898 169221640 169222022 382 0
p63 keratinocytesGSE17611 169190814 169191545 731 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21817 mRNA DOCK2 chr5 168996870 169442959 961 mRNA chr5 169305078 169306039 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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