AutismKB 2.0

Annotation Detail for DPYD


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Basic Information Top
Gene Symbol:DPYD ( DHP,DHPDHASE,DPD,MGC132008,MGC70799 )
Gene Full Name: dihydropyrimidine dehydrogenase
Band: 1p21.3
Quick LinksEntrez ID:1806; OMIM: 612779; Uniprot ID:DPYD_HUMAN; ENSEMBL ID: ENSG00000188641; HGNC ID: 3012
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
384N6-acetyllysine.
577Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
173N-linkedHMM predict
175Phosphoserine(PKA)HMM predict
175O-linkedHMM predict
276Phosphotyrosine(Syk)HMM predict
392Phosphoserine(CDK)HMM predict
392Phosphoserine(CDC2)HMM predict
440Phosphoserine(IKK)HMM predict
487N-linkedHMM predict
552Phosphothreonine(MAPK)HMM predict
552O-linkedHMM predict
555O-linkedHMM predict
577Phosphoserine(CAMK2)HMM predict
577Phosphoserine(PKC)HMM predict
587Phosphoserine(CDC2)HMM predict
600Phosphotyrosine(Abl)HMM predict
668N-linkedHMM predict
713N-linkedHMM predict
733O-linkedHMM predict
749Phosphothreonine(CDC2)HMM predict
858O-linkedHMM predict
905Phosphoserine(CDC2)HMM predict
905Phosphoserine(CDK)HMM predict
964N-linkedHMM predict
968Phosphotyrosine(Syk)HMM predict
968Phosphotyrosine(INSR)HMM predict
985O-linkedHMM predict
1018ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000110
  • Location:chr1 97315889-98159166
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T30-glioblastomaGSE21026 98175712 98176695 983 17037
RARA MCF7GSE15244 98176095 98176776 681 17269
STAT1 HeLaGSE12783 98175572 98176965 1393 17102
STAT1 IFNSISSRdata 98175618 98176750 1132 17018
hScc1 BcellGSE12603 98158812 98159545 733 12
p130 shRbSenescentGSE19898 98158844 98159578 734 45
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 97311153 97311190 37 4718
SRF GMOGSE8489 97314810 97315120 310 925
TFAP2C MCF7GSE21234 97301486 97302056 570 14119
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 97840807 97842434 1627 0
CBP T30-glioblastomaGSE21026 97819457 97820327 870 0
CTCF CD4GSE12889 97376519 97376685 166 0
CTCF CD4SISSRdata 97376519 97376685 166 0
CTCF G2GSE9613 98058624 98058842 218 0
CTCF G2GSE9613 98158739 98159253 514 0
ER E2-MCF7GSE14664 97484021 97484112 91 0
ER E2-MCF7GSE14664 97497230 97497267 37 0
ER E2-MCF7GSE14664 98080883 98080925 42 0
ER Fulvestrant-MCF7GSE14664 97497914 97498000 86 0
ER Fulvestrant-MCF7GSE14664 97704773 97704805 32 0
ER Fulvestrant-MCF7GSE14664 98080884 98080931 47 0
FOXA1 MCF7GSE15244 97430869 97431483 614 0
FoxA1 MCF7MACSdata 97431009 97431235 226 0
H3K4me3 colorectalcancer 98157774 98158775 1001 0
KLF4 hESGSE17917 98063926 98064097 171 0
Nanog ESGSE20650 97805232 97805533 301 0
Nanog hESGSE18292 97455693 97456014 321 0
Nanog hESGSE18292 97805181 97805520 339 0
Nanog hESGSE18292 97819992 97820486 494 0
Oct1 H2O2-HelaGSE14283 97323189 97323219 30 0
Oct1 H2O2-HelaGSE14283 97376237 97376267 30 0
Oct1 H2O2-HelaGSE14283 97498853 97498893 40 0
Oct1 H2O2-HelaGSE14283 97599452 97599479 27 0
Oct1 H2O2-HelaGSE14283 97810738 97810780 42 0
Oct1 H2O2-HelaGSE14283 97912042 97912092 50 0
Oct1 H2O2-HelaGSE14283 98069349 98069405 56 0
Oct1 HelaGSE14283 97376237 97376266 29 0
Oct1 HelaGSE14283 97450389 97450428 39 0
Oct1 HelaGSE14283 97498855 97498893 38 0
Oct1 HelaGSE14283 97519933 97519960 27 0
Oct1 HelaGSE14283 97539071 97539101 30 0
Oct1 HelaGSE14283 97810737 97810780 43 0
Oct1 HelaGSE14283 97911853 97911902 49 0
Oct1 HelaGSE14283 97912046 97912095 49 0
Oct1 HelaGSE14283 97956655 97956689 34 0
Oct1 HelaGSE14283 98069349 98069402 53 0
Oct1 HelaGSE14283 98080884 98080924 40 0
Oct1 HelaGSE14283 98130568 98130597 29 0
P300 T0-glioblastomaGSE21026 98087855 98089244 1389 0
P300 T30-glioblastomaGSE21026 97430703 97431837 1134 0
P300 T30-glioblastomaGSE21026 98087983 98088638 655 0
PAX3-FKHR Rh4GSE19063 97619181 97620121 940 0
PAX3-FKHR Rh4GSE19063 98034240 98036249 2009 0
PAX3-FKHR Rh4GSE19063 98070051 98071162 1111 0
RARA MCF7GSE15244 97430905 97431483 578 0
RNAII Tamoxifen-MCF7GSE14664 97458054 97458144 90 0
RNAII Tamoxifen-MCF7GSE14664 97519927 97519965 38 0
Rb QuiescentGSE19898 97576800 97576953 153 0
Rb SenescentGSE19898 98158629 98159429 800 0
Rb shRbSenescenceGSE19898 98158747 98159068 321 0
SRF HepG2GSE8489 97479997 97480237 240 0
STAT1 HeLaGSE12782 97515456 97517220 1764 0
STAT1 HeLaGSE12783 97331888 97333176 1288 0
STAT1 HeLaGSE12783 97515554 97517186 1632 0
STAT1 IFNSISSRdata 97515714 97517244 1530 0
STAT1 IFNSISSRdata 97727921 97728392 471 0
Stat6 IL-4-hr4GSE17850 97384079 97384539 460 0
TAF k562GSE8489 97847483 97848256 773 0
TAF k562GSE8489 98146489 98147632 1143 0
TFAP2C MCF7GSE21234 97412257 97412878 621 0
TFAP2C MCF7GSE21234 97440709 97440979 270 0
hScc1 BcellGSE12603 97376481 97376839 358 0
hScc1 BcellGSE12603 98058544 98058881 337 0
hScc1 CdLSGSE12603 97376331 97377092 761 0
hScc1 CdLSGSE12603 97481868 97482850 982 0
hScc1 CdLSGSE12603 97763625 97763874 249 0
hScc1 CdLSGSE12603 98058234 98058915 681 0
p63 keratinocytesGSE17611 97319955 97320952 997 0
p63 keratinocytesGSE17611 97606300 97607158 858 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
1161 EST chr1 97443005 97500532 109 mRNA DPYD chr1 97255322 98098600Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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