Annotation Detail for DSG2

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Basic Information Top

Gene Symbol:	DSG2 ( ARVC10,ARVD10,CDHF5,CMD1BB,HDGC,MGC117034,MGC117036,MGC117037 )
Gene Full Name:	desmoglein 2
Band:	18q12.1
Quick Links	Entrez ID:1829; OMIM: 125671; Uniprot ID:DSG2_HUMAN; ENSEMBL ID: ENSG00000046604; HGNC ID: 3049
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
PHF8	293T	GSE20725	27331525	27332758	1233	28
hScc1	Bcell	GSE12603	27331729	27332517	788	47

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	27389853	27390187	334	9267
CTCF	CD4	SISSRdata	27389853	27390187	334	9267
CTCF	G2	GSE9613	27389728	27390204	476	9213
CTCF	G2	GSE9613	27391494	27391637	143	10812
Oct1	H2O2-Hela	GSE14283	27383834	27383864	30	3096
Oct1	Hela	GSE14283	27383836	27383864	28	3097
Rb	shRbSenescence	GSE19898	27389998	27390222	224	9357
hScc1	Bcell	GSE12603	27389691	27390416	725	9300
hScc1	CdLS	GSE12603	27389630	27390735	1105	9429
hScc1	G2	GSE9613	27389592	27390312	720	9199

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
H3ac	HepG2	E	27333074	27333787	713
TFAP2C	MCF7	GSE21234	27332252	27332736	484
USF2	HepG2	E	27346011	27346572	561

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
956	Unknown	pSILAC	miR-155	DSG2	down 75-50%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000046604		n_a	n_a	n_a	muscle cell	"benign tumour, malignant tumour, carcinoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
12042	mRNA	DSG2	chr18	27332202	27380855	171	mRNA		chr18	27376108	27390872	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018