Annotation Detail for DUSP6
Basic Information Top
| Gene Symbol: | DUSP6 ( MKP3,PYST1 ) |
|---|---|
| Gene Full Name: | dual specificity phosphatase 6 |
| Band: | 12q21.33 |
| Quick Links | Entrez ID:1848; OMIM: 602748; Uniprot ID:DUS6_HUMAN; ENSEMBL ID: ENSG00000139318; HGNC ID: 3072 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 331 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 159 | Phosphoserine (MAPK1;MAPK3) | Phospho.ELM 6.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 17 | Phosphoserine(PKG) | HMM predict |
| 87 | Phosphothreonine(PKA) | HMM predict |
| 87 | Phosphothreonine(PKC) | HMM predict |
| 102 | Phosphoserine(CK1) | HMM predict |
| 103 | Phosphoserine(CK2) | HMM predict |
| 154 | Phosphoserine(IKK) | HMM predict |
| 157 | O-linked | HMM predict |
| 174 | Phosphoserine(CK2) | HMM predict |
| 176 | Phosphoserine(CK2) | HMM predict |
| 178 | Phosphoserine(CK1) | HMM predict |
| 190 | Phosphoserine(IKK) | HMM predict |
| 194 | Phosphoserine(ATM) | HMM predict |
| 197 | Phosphoserine(IKK) | HMM predict |
| 200 | Phosphoserine(IKK) | HMM predict |
| 202 | Phosphoserine(ATM) | HMM predict |
| 238 | N-linked | HMM predict |
| 240 | Phosphothreonine(CDC2) | HMM predict |
| 242 | N-linked | HMM predict |
| 255 | Phosphotyrosine(EGFR) | HMM predict |
| 261 | Phosphoserine(ATM) | HMM predict |
| 265 | Phosphoserine(IKK) | HMM predict |
| 267 | N-linked | HMM predict |
| 304 | O-linked | HMM predict |
| 328 | Phosphoserine(PKG) | HMM predict |
| 373 | Phosphotyrosine(Syk) | HMM predict |
- RefSeq ID: NM_001946
- Location:chr12 88265969-88270426
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | G2 | GSE9613 | 88271396 | 88272364 | 968 | 1454 |
| CTCF | G2 | GSE9613 | 88273202 | 88273383 | 181 | 2866 |
| CTCF | G2 | GSE9613 | 88287851 | 88288041 | 190 | 17520 |
| FOXA1 | DLD1 | GSE12801 | 88270329 | 88271097 | 768 | 287 |
| FOXA1 | DLD1 | GSE12801 | 88288351 | 88290195 | 1844 | 18847 |
| FOXA1 | MCF7 | GSE15244 | 88270066 | 88271180 | 1114 | 197 |
| FOXA1 | MCF7 | GSE15244 | 88273086 | 88273420 | 334 | 2827 |
| H3K4me3 | colorectal | cancer | 88272602 | 88272878 | 276 | 2314 |
| H3ac | HepG2 | E | 88270101 | 88270990 | 889 | 119 |
| H3ac | HepG2 | E | 88272495 | 88273644 | 1149 | 2643 |
| H3ac | HepG2 | E | 88274014 | 88274762 | 748 | 3962 |
| NRSF-mono | Jurkat | QuESTdata | 88282560 | 88282994 | 434 | 12351 |
| NRSF-poly | Jurkat | QuESTdata | 88282585 | 88282851 | 266 | 12292 |
| Oct1 | H2O2-Hela | GSE14283 | 88286555 | 88286583 | 28 | 16143 |
| Oct1 | H2O2-Hela | GSE14283 | 88288209 | 88288235 | 26 | 17796 |
| Oct1 | H2O2-Hela | GSE14283 | 88290308 | 88290339 | 31 | 19897 |
| Oct1 | Hela | GSE14283 | 88288207 | 88288238 | 31 | 17796 |
| Oct1 | Hela | GSE14283 | 88290275 | 88290345 | 70 | 19884 |
| RARA | MCF7 | GSE15244 | 88270354 | 88271223 | 869 | 362 |
| RARA | MCF7 | GSE15244 | 88273086 | 88273535 | 449 | 2884 |
| RARG | MCF7 | GSE15244 | 88270389 | 88271180 | 791 | 358 |
| RARG | MCF7 | GSE15244 | 88272328 | 88273494 | 1166 | 2485 |
| Rb | Senescent | GSE19898 | 88271891 | 88272262 | 371 | 1650 |
| TFAP2C | MCF7 | GSE21234 | 88288234 | 88288856 | 622 | 18119 |
| USF2 | HepG2 | E | 88270354 | 88270990 | 636 | 246 |
| hScc1 | Bcell | GSE12603 | 88271481 | 88272328 | 847 | 1478 |
| p130 | Quiescent | GSE19898 | 88270396 | 88271017 | 621 | 280 |
| p130 | Senescent | GSE19898 | 88270572 | 88270984 | 412 | 352 |
| p130 | shRbQuiescent | GSE19898 | 88270435 | 88271360 | 925 | 471 |
| p63 | keratinocytes | GSE17611 | 88288276 | 88289358 | 1082 | 18391 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| H3ac | HepG2 | E | 88262044 | 88263088 | 1044 | 3404 |
| TFAP2C | MCF7 | GSE21234 | 88246386 | 88247015 | 629 | 19269 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | G2 | GSE9613 | 88269328 | 88269889 | 561 | 0 |
| H3K4me3 | colorectal | cancer | 88267921 | 88269223 | 1302 | 0 |
| H3ac | HepG2 | E | 88266348 | 88269368 | 3020 | 0 |
| Oct4 | hES | GSE21916 | 88267709 | 88268991 | 1282 | 0 |
| hScc1 | Bcell | GSE12603 | 88269249 | 88269675 | 426 | 0 |
| hScc1 | G2 | GSE9613 | 88269121 | 88270175 | 1054 | 0 |
| p130 | Quiescent | GSE19898 | 88267791 | 88268047 | 256 | 0 |
| p130 | Senescent | GSE19898 | 88267625 | 88268127 | 502 | 0 |
| p130 | shRbQuiescent | GSE19898 | 88268406 | 88268918 | 512 | 0 |
Validated miRNA targets| Cluster ID | Plue Type | Plus Gene Name | Plus Chromosome | Plus Start | Plus End | Overlap Length | Minus Type | Minus Gene Name | Minus Chromosome | Minus Star | Minus End | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6395 | mRNA | chr12 | 88247259 | 88249513 | 891 | mRNA | DUSP6 | chr12 | 88244306 | 88248764 | Sense/Antisense (SA) pairs | |