Annotation Detail for AGTR1

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	AGTR1 ( AG2S,AGTR1A,AGTR1B,AT1,AT1B,AT1R,AT2R1,AT2R1A,AT2R1B,HAT1R )
Gene Full Name:	angiotensin II receptor, type 1
Band:	3q24
Quick Links	Entrez ID:185; OMIM: 106165; Uniprot ID:AGTR1_HUMAN; ENSEMBL ID: ENSG00000144891; HGNC ID: 336
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modifications	Resource
4	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
176	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
188	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
319	Phosphotyrosine	Phospho.ELM 6.0
355	S-palmitoyl cysteine (Potential).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	MCF7	GSE15244	149888256	149888986	730	9734
Rb	Growing	GSE19898	149888466	149888628	162	9808

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	149898317	149898677	360
CTCF	G2	GSE9613	149927779	149928059	280
FOXA1	MCF7	GSE15244	149934788	149935511	723
FoxA1	MCF7	MACSdata	149934798	149935162	364
H3K27me3	colorectal	cancer	149898828	149899640	812
RARA	MCF7	GSE15244	149934754	149935834	1080
hScc1	G2	GSE9613	149919407	149919698	291
hScc1	G2	GSE9613	149927742	149928128	386

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-150	hsa-mir-150	19	19177201
hsa-miR-150*	hsa-mir-150	19	19177201
hsa-miR-155	hsa-mir-155	21	21310411
hsa-miR-155	hsa-mir-155	21	20966899
hsa-miR-155	hsa-mir-155	21	19177201
hsa-miR-155	hsa-mir-155	21	17668390
hsa-miR-155	hsa-mir-155	21	17588946
hsa-miR-155	hsa-mir-155	21	16675453
hsa-miR-155*	hsa-mir-155	21	21310411
hsa-miR-155*	hsa-mir-155	21	20966899
hsa-miR-155*	hsa-mir-155	21	19177201
hsa-miR-155*	hsa-mir-155	21	17668390
hsa-miR-155*	hsa-mir-155	21	17588946
hsa-miR-155*	hsa-mir-155	21	16675453
hsa-miR-16	hsa-mir-16-1	13	19177201
hsa-miR-16	hsa-mir-16-2	3	19177201
hsa-miR-17	hsa-mir-17	13	19177201
hsa-miR-17*	hsa-mir-17	13	19177201
hsa-miR-21	hsa-mir-21	17	19177201
hsa-miR-21*	hsa-mir-21	17	19177201
hsa-miR-221	hsa-mir-221	X	21310411
hsa-miR-221*	hsa-mir-221	X	21310411
hsa-miR-222	hsa-mir-222	X	21310411
hsa-miR-222*	hsa-mir-222	X	21310411
hsa-miR-24	hsa-mir-24-1	9	19177201
hsa-miR-24	hsa-mir-24-2	19	19177201
hsa-miR-802	hsa-mir-802	21	20558762
hsa-miR-92a	hsa-mir-92a-1	13	19177201
hsa-miR-92a	hsa-mir-92a-2	X	19177201

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
474	mRNA repression	TRUE	miR-155	AGTR1	in vitro reporter gene assay (Luciferase)	16675453
475	Unknown	TRUE	miR-155	AGTR1	Luciferase assay - mutant MRE - mutant miRNA	17588946
476	Unknown	TRUE	miR-155	AGTR1	Reporter assay	17668390
477	Unknown	FALSE	miR-155	AGTR1	Reporter assay	17668390
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000144891		"activated B and T cells - B-cell development, smooth muscle, endothelium"	n_a	n_a	n_a	"malignant tumour, sarcoma"
ENSG00000144891		"activated B and T cells - B-cell development, smooth muscle, endothelium"	cardiovascular disease	MRE disruption	n_a	"malignant tumour, sarcoma"
ENSG00000144891		"activated B and T cells - B-cell development, smooth muscle, endothelium"	n_a	n_a	n_a	"malignant tumour, sarcoma"
ENSG00000144891		"activated B and T cells - B-cell development, smooth muscle, endothelium"	n_a	n_a	n_a	"malignant tumour, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018