AutismKB 2.0

Annotation Detail for DYRK1A


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Basic Information Top
Gene Symbol:DYRK1A ( DYRK,DYRK1,HP86,MNB,MNBH )
Gene Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Band: 21q22.13
Quick LinksEntrez ID:1859; OMIM: 600855; Uniprot ID:DYR1A_HUMAN; ENSEMBL ID: ENSG00000157540; HGNC ID: 3091
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
134Bipartite nuclear localization signal
145Phosphotyrosine.
219Phosphotyrosine; by autocatalysis (By
319Phosphotyrosine; by autocatalysis (By
321Phosphotyrosine; by autocatalysis.
324Phosphoserine.
748Phosphoserine.
758Phosphoserine.
Location(AA) Modifications Resource
145Phosphotyrosine.Swiss-Prot 53.0
145PhosphotyrosinePhospho.ELM 6.0
219Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
319Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
319PhosphotyrosinePhospho.ELM 6.0
321Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
321PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
47N-linkedHMM predict
134MethyllysineHMM predict
140Phosphotyrosine(Syk)HMM predict
145SulfotyrosineHMM predict
145Phosphotyrosine(INSR)HMM predict
327Phosphotyrosine(EGFR)HMM predict
329Phosphoserine(CDC2)HMM predict
415Phosphotyrosine(Syk)HMM predict
480MethyllysineHMM predict
481MethyllysineHMM predict
488N-linkedHMM predict
490O-linkedHMM predict
491N-linkedHMM predict
492O-linkedHMM predict
496Phosphoserine(CDC2)HMM predict
496Phosphoserine(CDK)HMM predict
496PhosphoserineHMM predict
502Phosphoserine(ATM)HMM predict
504Phosphoserine(IKK)HMM predict
505Phosphoserine(CK1)HMM predict
505O-linkedHMM predict
505O-linkedHMM predict
507O-linkedHMM predict
508O-linkedHMM predict
509Phosphoserine(IKK)HMM predict
511O-linkedHMM predict
512O-linkedHMM predict
513Phosphoserine(CK1)HMM predict
514Phosphoserine(CDC2)HMM predict
515Phosphoserine(ATM)HMM predict
604N-linkedHMM predict
626N-linkedHMM predict
635Phosphoserine(CDK)HMM predict
635Phosphoserine(CDC2)HMM predict
638N-linkedHMM predict
639Phosphoserine(CK1)HMM predict
657Phosphoserine(CK1)HMM predict
661O-linkedHMM predict
661Phosphoserine(IKK)HMM predict
662O-linkedHMM predict
663O-linkedHMM predict
664Phosphoserine(CK1)HMM predict
667O-linkedHMM predict
668O-linkedHMM predict
669Phosphoserine(CK1)HMM predict
670Phosphoserine(CDC2)HMM predict
670Phosphoserine(CK1)HMM predict
680Phosphotyrosine(Syk)HMM predict
689Phosphothreonine(PKC)HMM predict
701N-linkedHMM predict
707N-linkedHMM predict
712Phosphothreonine(PKA)HMM predict
731Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001396
  • Location:chr21 37714471-37809547
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 37827145 37827863 718 17957
TFAP2C MCF7GSE21234 37825606 37826206 600 16359
TFAP2C MCF7GSE21234 37827235 37828012 777 18076
hScc1 BcellGSE12603 37825664 37826068 404 16319
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 37740660 37741140 480 0
FOXA1 MCF7GSE15244 37806073 37806609 536 0
Fos K562GSE19551 37729135 37729724 589 0
Fos K562GSE19551 37803870 37804502 632 0
Myc K562GSE19551 37744604 37745213 609 0
Nanog ESGSE20650 37792841 37793358 517 0
TFAP2C MCF7GSE21234 37761306 37761664 358 0
hScc1 CdLSGSE12603 37757163 37757591 428 0
p130 QuiescentGSE19898 37746544 37746683 139 0
p130 QuiescentGSE19898 37754141 37754360 219 0
p63 keratinocytesGSE17611 37724500 37725341 841 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-199b-3p hsa-mir-199b 9 21102440
hsa-miR-199b-5p hsa-mir-199b 9 21102440
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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