Annotation Detail for S1PR1

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Basic Information Top

Gene Symbol:	S1PR1 ( CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,FLJ58121,S1P1 )
Gene Full Name:	sphingosine-1-phosphate receptor 1
Band:	1p21.2
Quick Links	Entrez ID:1901; OMIM: 601974; Uniprot ID:S1PR1_HUMAN; ENSEMBL ID: ENSG00000170989; HGNC ID: 3165
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:0 results

Location(AA)	Modification
30	N-linked (GlcNAc...) (Potential).
36	N-linked (GlcNAc...) (Potential).
236	Phosphothreonine; by PKB/AKT1.
353	Phosphoserine (Potential).

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001400
Location:chr1 101475042-101479660
strand:+

Upstream the gene:6 results
Downstream the gene:1 results
Inside the gene:7 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K27me3	colorectal	cancer	101472351	101472686	335	2524
H3K27me3	colorectal	cancer	101473441	101473747	306	1449
H3K27me3	colorectal	cancer	101474001	101474561	560	762
Rb	Growing	GSE19898	101474302	101474473	171	655
Rb	Quiescent	GSE19898	101474483	101474600	117	501
hScc1	Bcell	GSE12603	101473928	101474524	596	817

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
TFAP2C	MCF7	GSE21234	101496060	101496413	353	16576

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	101476892	101477253	361	0
CTCF	CD4	SISSRdata	101476892	101477253	361	0
CTCF	G2	GSE9613	101476863	101477680	817	0
H3K27me3	colorectal	cancer	101475137	101476473	1336	0
hScc1	Bcell	GSE12603	101476620	101477711	1091	0
hScc1	CdLS	GSE12603	101473510	101477578	4068	0
hScc1	G2	GSE9613	101476899	101477364	465	0

Validated miRNA targets

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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