AutismKB 2.0

Annotation Detail for EIF2C3


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Basic Information Top
Gene Symbol:EIF2C3 ( AGO3,FLJ12765,MGC86946 )
Gene Full Name: eukaryotic translation initiation factor 2C, 3
Band: 1p34.3
Quick LinksEntrez ID:192669; OMIM: 607355; Uniprot ID:AGO3_HUMAN; ENSEMBL ID: ENSG00000126070; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_024852
  • Location:chr1 36169358-36294648
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 36168849 36169741 892 64
H3ac HepG2E 36168448 36168828 380 721
Oct1 H2O2-HelaGSE14283 36168897 36168933 36 444
Oct1 HelaGSE14283 36168897 36168938 41 441
PHF8 HeLaGSE20725 36168538 36170105 1567 37
PHF8 Hs68minusFBSGSE20725 36168380 36169811 1431 263
PHF8 Hs68plusFBSGSE20725 36168260 36170408 2148 25
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 36169053 36169686 633 0
GABP k562GSE8489 36169962 36171436 1474 0
H3ac HepG2E 36169782 36171472 1690 0
Oct1 H2O2-HelaGSE14283 36235645 36235673 28 0
Oct1 HelaGSE14283 36178814 36178872 58 0
Oct1 HelaGSE14283 36180816 36180842 26 0
Oct1 HelaGSE14283 36254738 36254769 31 0
Oct1 HelaGSE14283 36265459 36265544 85 0
hScc1 BcellGSE12603 36168983 36169860 877 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-129* hsa-mir-129-1 7 18189265
hsa-miR-129-3p hsa-mir-129-2 11 18189265
hsa-miR-129-5p hsa-mir-129-1 7 18189265
hsa-miR-129-5p hsa-mir-129-2 11 18189265
hsa-miR-182 hsa-mir-182 7 21282978
hsa-miR-182* hsa-mir-182 7 21282978
hsa-miR-222 hsa-mir-222 X 21282978
hsa-miR-222* hsa-mir-222 X 21282978
hsa-miR-223* hsa-mir-223 X 21282978
hsa-miR-520h hsa-mir-520h 19 18189265
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
441 Unknown TRUE miR-129 EIF2C3 pMIR-REPORT 18189265
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000126070 hematopoietic stem cells (HSCs) hematopoietic stem cell differentiation down regulated "lymphocyte, muscle cell" "malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
571 mRNA EIF2C3 chr1 36065864 36191155 86 EST chr1 36144074 36148324Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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