AutismKB 2.0

Annotation Detail for EEF2


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Basic Information Top
Gene Symbol:EEF2 ( EEF-2,EF2 )
Gene Full Name: eukaryotic translation elongation factor 2
Band: 19p13.3
Quick LinksEntrez ID:1938; OMIM: 130610; Uniprot ID:EF2_HUMAN; ENSEMBL ID: ENSG00000167658; HGNC ID: 3214
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
48Phosphoserine.
54Phosphothreonine (By similarity).
57Phosphothreonine.
59Phosphothreonine (By similarity).
235N6-acetyllysine.
239N6-acetyllysine.
265Phosphotyrosine.
272N6-acetyllysine.
275N6-acetyllysine.
318N6-acetyllysine.
435Phosphothreonine.
445N6-acetyllysine.
502Phosphoserine.
715Diphthamide.
857N6-acetyllysine.
Location(AA) Modifications Resource
53PhosphothreoninePhospho.ELM 6.0
54Phosphothreonine (By similarity).Swiss-Prot 53.0
56PhosphothreoninePhospho.ELM 6.0
57Phosphothreonine.Swiss-Prot 53.0
58PhosphothreoninePhospho.ELM 6.0
59Phosphothreonine (By similarity).Swiss-Prot 53.0
265Phosphotyrosine.Swiss-Prot 53.0
501PhosphoserinePhospho.ELM 6.0
502Phosphoserine.Swiss-Prot 53.0
715Diphthamide.Swiss-Prot 53.0
Location(AA) Modification Resource
38O-linkedHMM predict
175Phosphotyrosine(Syk)HMM predict
274O-linkedHMM predict
278Phosphothreonine(PKC)HMM predict
279Phosphoserine(MAPK)HMM predict
279Phosphoserine(CDC2)HMM predict
360O-linkedHMM predict
433N-linkedHMM predict
435Phosphothreonine(CDC2)HMM predict
443Phosphotyrosine(Jak)HMM predict
443Phosphotyrosine(INSR)HMM predict
502Phosphoserine(CDC2)HMM predict
582Phosphothreonine(PKC)HMM predict
827N-linkedHMM predict
838Phosphothreonine(PKC)HMM predict
848IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001961
  • Location:chr19 3927054-3936460
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 3936091 3936973 882 72
CTCF G2GSE9613 3938803 3938973 170 2428
ER E2-MCF7GSE14664 3947054 3947089 35 10611
ER Fulvestrant-MCF7GSE14664 3947035 3947084 49 10599
ETS1 JurkatGSE17954 3940897 3941820 923 4898
Fos K562GSE19551 3941031 3941596 565 4853
H3K4me2 HCT116GSE10453 3936599 3936973 374 326
Myc K562GSE19551 3941137 3941655 518 4936
Nanog hESGSE18292 3941259 3941517 258 4928
Oct1 HelaGSE14283 3947029 3947123 94 10616
Sox2 hESGSE18292 3941184 3941487 303 4875
TAF HelaGSE8489 3936478 3936973 495 265
TFAP2C MCF7GSE21234 3946507 3947005 498 10296
USF2 HepG2E 3936478 3936973 495 265
hScc1 BcellGSE12603 3938803 3938973 170 2428
hScc1 CdLSGSE12603 3937321 3937724 403 1062
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 3930192 3931249 1057 0
H3ac HepG2E 3934081 3936200 2119 0
HIF1 NormHepG2 3935808 3936973 1165 0
PHF8 293TGSE20725 3935309 3936624 1315 0
PHF8 HeLaGSE20725 3935772 3936763 991 0
Pol2 GM12878GSE19551 3926143 3928655 2512 0
Pol2 GM12878GSE19551 3936005 3936755 750 0
TAF HelaGSE8489 3934425 3936091 1666 0
TAF k562GSE8489 3934319 3936973 2654 0
USF1 HepG2E 3934127 3934955 828 0
USF1 HepG2E 3935468 3936973 1505 0
VDR GM10855-UnstimGSE22484 3925984 3929706 3722 0
hScc1 BcellGSE12603 3934204 3934642 438 0
hScc1 BcellGSE12603 3935206 3935391 185 0
hScc1 BcellGSE12603 3936030 3936510 480 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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