Annotation Detail for EGFR

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Basic Information Top

Gene Symbol:	EGFR ( ERBB,ERBB1,HER1,PIG61,mENA )
Gene Full Name:	epidermal growth factor receptor
Band:	7p11.2
Quick Links	Entrez ID:1956; OMIM: 131550; Uniprot ID:EGFR_HUMAN; ENSEMBL ID: ENSG00000146648; HGNC ID: 3236
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:40 results
Experimental PTM Sites from dbPTM:64 results
Predicted PTM Sites by profile HMM from dbPTM:45 results

Location(AA)	Modification
56	N-linked (GlcNAc...) (complex); atypical;
128	N-linked (GlcNAc...).
175	N-linked (GlcNAc...).
196	N-linked (GlcNAc...).
352	N-linked (GlcNAc...).
361	N-linked (GlcNAc...).
413	N-linked (GlcNAc...).
444	N-linked (GlcNAc...).
528	N-linked (GlcNAc...).
568	N-linked (GlcNAc...); partial.
603	N-linked (GlcNAc...); partial.
678	Phosphothreonine; by PKC.
693	Phosphothreonine.
695	Phosphoserine.
725	Phosphothreonine.
869	Phosphotyrosine.
978	Phosphotyrosine.
991	Phosphoserine.
993	Phosphothreonine.
995	Phosphoserine.
998	Phosphotyrosine; by autocatalysis.
1016	Phosphotyrosine; by autocatalysis.
1025	Phosphoserine.
1026	Phosphoserine.
1037	Phosphoserine.
1039	Phosphoserine.
1041	Phosphothreonine.
1042	Phosphoserine.
1045	Phosphoserine.
1064	Phosphoserine.
1069	Phosphotyrosine.
1070	Phosphoserine.
1071	Phosphoserine.
1081	Phosphoserine.
1092	Phosphotyrosine; by autocatalysis.
1110	Phosphotyrosine; by autocatalysis.
1138	Phosphotyrosine.
1166	Phosphoserine.
1172	Phosphotyrosine; by autocatalysis.
1197	Phosphotyrosine; by autocatalysis.

Location(AA)	Modifications	Resource
56	N-linked (GlcNAc...) (complex); atypical;partial./FTId=CAR
128	N-linked (GlcNAc...).	Swiss-Prot 53.0
175	N-linked (GlcNAc...).	Swiss-Prot 53.0
196	N-linked (GlcNAc...).	Swiss-Prot 53.0
352	N-linked (GlcNAc...).	Swiss-Prot 53.0
361	N-linked (GlcNAc...).	Swiss-Prot 53.0
413	N-linked (GlcNAc...).	Swiss-Prot 53.0
444	N-linked (GlcNAc...).	Swiss-Prot 53.0
528	N-linked (GlcNAc...).	Swiss-Prot 53.0
568	N-linked (GlcNAc...); partial.	Swiss-Prot 53.0
603	N-linked (GlcNAc...); partial.	Swiss-Prot 53.0
678	Phosphothreonine; by PKC.	Swiss-Prot 53.0
678	Phosphothreonine (PKC alpha;PK)	Phospho.ELM 6.0
693	Phosphothreonine (ERT PK;MAPK1)	Phospho.ELM 6.0
693	Phosphothreonine.	Swiss-Prot 53.0
695	Phosphoserine	Phospho.ELM 6.0
695	Phosphoserine.	Swiss-Prot 53.0
716	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).	Swiss-Prot 53.0
737	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).	Swiss-Prot 53.0
754	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).	Swiss-Prot 53.0
768	Phosphoserine (CaM-KIIalpha)	Phospho.ELM 6.0
867	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).	Swiss-Prot 53.0
869	Phosphotyrosine (Src)	Phospho.ELM 6.0
915	Phosphotyrosine (Src)	Phospho.ELM 6.0
929	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).	Swiss-Prot 53.0
944	Phosphotyrosine (Src)	Phospho.ELM 6.0
970	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).	Swiss-Prot 53.0
978	Phosphotyrosine	Phospho.ELM 6.0
978	Phosphotyrosine.	Swiss-Prot 53.0
991	Phosphoserine	Phospho.ELM 6.0
991	Phosphoserine.	Swiss-Prot 53.0
995	Phosphoserine.	Swiss-Prot 53.0
998	Phosphotyrosine	Phospho.ELM 6.0
998	Phosphotyrosine.	Swiss-Prot 53.0
1016	Phosphotyrosine (EGFR)	Phospho.ELM 6.0
1026	Phosphoserine (CDK1)	Phospho.ELM 6.0
1026	Phosphoserine.	Swiss-Prot 53.0
1028	Phosphoserine	Phospho.ELM 6.0
1039	Phosphoserine	Phospho.ELM 6.0
1042	Phosphoserine	Phospho.ELM 6.0
1045	Phosphoserine	Phospho.ELM 6.0
1064	Phosphoserine.	Swiss-Prot 53.0
1064	Phosphoserine	Phospho.ELM 6.0
1069	Phosphotyrosine.	Swiss-Prot 53.0
1069	Phosphotyrosine	Phospho.ELM 6.0
1070	Phosphoserine.	Swiss-Prot 53.0
1070	Phosphoserine (CaM-KIIalpha)	Phospho.ELM 6.0
1071	Phosphoserine.	Swiss-Prot 53.0
1071	Phosphoserine (CaM-KIIalpha)	Phospho.ELM 6.0
1081	Phosphoserine (CaM-KIIalpha)	Phospho.ELM 6.0
1092	Phosphotyrosine (EGFR)	Phospho.ELM 6.0
1092	Phosphotyrosine; by autocatalysis.	Swiss-Prot 53.0
1104	Phosphoserine	Phospho.ELM 6.0
1110	Phosphotyrosine (EGFR)	Phospho.ELM 6.0
1110	Phosphotyrosine; by autocatalysis.	Swiss-Prot 53.0
1125	Phosphotyrosine (Src)	Phospho.ELM 6.0
1138	Phosphotyrosine.	Swiss-Prot 53.0
1166	Phosphoserine (CaM-KIIalpha)	Phospho.ELM 6.0
1166	Phosphoserine.	Swiss-Prot 53.0
1172	Phosphotyrosine (EGFR)	Phospho.ELM 6.0
1172	Phosphotyrosine; by autocatalysis.	Swiss-Prot 53.0
1190	Phosphoserine	Phospho.ELM 6.0
1197	Phosphotyrosine; by autocatalysis.	Swiss-Prot 53.0
1197	Phosphotyrosine (EGFR)	Phospho.ELM 6.0

Location(AA)	Modification	Resource
128	N-linked	HMM predict
196	N-linked	HMM predict
271	N-linked	HMM predict
275	Phosphotyrosine(Abl)	HMM predict
315	Phosphoserine	HMM predict
333	S-palmitoyl	HMM predict
350	Phosphoserine(IKK)	HMM predict
352	N-linked	HMM predict
355	N-linked	HMM predict
361	N-linked	HMM predict
413	N-linked	HMM predict
444	N-linked	HMM predict
568	N-linked	HMM predict
603	N-linked	HMM predict
604	N-linked	HMM predict
623	N-linked	HMM predict
678	Phosphothreonine(PKA)	HMM predict
678	Phosphothreonine(PKC)	HMM predict
693	Phosphothreonine(MAPK)	HMM predict
752	Phosphoserine(MAPK)	HMM predict
752	Phosphoserine(CDC2)	HMM predict
869	Phosphotyrosine(SRC)	HMM predict
869	Phosphotyrosine(Syk)	HMM predict
892	Phosphothreonine	HMM predict
915	Phosphotyrosine(Syk)	HMM predict
978	Phosphotyrosine(Syk)	HMM predict
978	Phosphotyrosine(Jak)	HMM predict
998	Phosphotyrosine(Syk)	HMM predict
1016	Phosphotyrosine(Jak)	HMM predict
1016	Phosphotyrosine(Syk)	HMM predict
1026	Phosphoserine(CDC2)	HMM predict
1030	O-linked	HMM predict
1032	Phosphothreonine(MAPK)	HMM predict
1032	Phosphothreonine(CDK)	HMM predict
1042	O-linked	HMM predict
1042	Phosphoserine(IKK)	HMM predict
1043	N-linked	HMM predict
1044	N-linked	HMM predict
1071	Phosphoserine(ATM)	HMM predict
1094	N-linked	HMM predict
1120	O-linked	HMM predict
1125	Sulfotyrosine	HMM predict
1148	N-linked	HMM predict
1166	Phosphoserine(CAMK2)	HMM predict
1172	Sulfotyrosine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_005228
Location:chr7 55054218-55242523
strand:+

Upstream the gene:0 results
Downstream the gene:2 results
Inside the gene:13 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	55248662	55249038	376	6327
NRSF	pAb	Jurkat	55253114	55253363	249	10715

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	55212447	55212667	220
CTCF	G2	GSE9613	55217015	55217715	700
CTCF	G2	GSE9613	55221244	55221448	204
CTCF	G2	GSE9613	55222043	55222409	366
CTCF	G2	GSE9613	55224086	55224523	437
CTCF	G2	GSE9613	55240528	55240782	254
H3ac	HepG2	E	55212778	55213960	1182
Nanog	hES	GSE18292	55227014	55227520	506
Oct1	H2O2-Hela	GSE14283	55241580	55241609	29
P300	T30-glioblastoma	GSE21026	55220361	55222157	1796
P300	T30-glioblastoma	GSE21026	55227589	55228665	1076
Rb	Senescent	GSE19898	55227784	55228415	631
TFAP2C	MCF7	GSE21234	55221316	55221821	505

Validated miRNA targets

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miR Walk:162 results
Tarbase V5.0:2 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	20097187
hsa-let-7a	hsa-let-7a-2	11	20097187
hsa-let-7a	hsa-let-7a-3	22	20097187
hsa-let-7a	hsa-let-7a-1	9	20177422
hsa-let-7a	hsa-let-7a-2	11	20177422
hsa-let-7a	hsa-let-7a-3	22	20177422
hsa-let-7a	hsa-let-7a-1	9	17728006
hsa-let-7a	hsa-let-7a-2	11	17728006
hsa-let-7a	hsa-let-7a-3	22	17728006
hsa-let-7a*	hsa-let-7a-1	9	20177422
hsa-let-7a*	hsa-let-7a-3	22	20177422
hsa-let-7a*	hsa-let-7a-1	9	17728006
hsa-let-7a*	hsa-let-7a-3	22	17728006
hsa-let-7b	hsa-let-7b	22	20177422
hsa-let-7b	hsa-let-7b	22	17728006
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	20177422
hsa-let-7b*	hsa-let-7b	22	17728006
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-let-7c	hsa-let-7c	21	20177422
hsa-let-7c	hsa-let-7c	21	17728006
hsa-let-7c*	hsa-let-7c	21	20177422
hsa-let-7c*	hsa-let-7c	21	17728006
hsa-let-7d	hsa-let-7d	9	21266476
hsa-let-7d	hsa-let-7d	9	20177422
hsa-let-7d	hsa-let-7d	9	17728006
hsa-let-7d*	hsa-let-7d	9	21266476
hsa-let-7d*	hsa-let-7d	9	20177422
hsa-let-7d*	hsa-let-7d	9	17728006
hsa-let-7e	hsa-let-7e	19	20177422
hsa-let-7e	hsa-let-7e	19	17728006
hsa-let-7e*	hsa-let-7e	19	20177422
hsa-let-7e*	hsa-let-7e	19	17728006
hsa-let-7f	hsa-let-7f-1	9	20177422
hsa-let-7f	hsa-let-7f-2	X	20177422
hsa-let-7f	hsa-let-7f-1	9	17728006
hsa-let-7f	hsa-let-7f-2	X	17728006
hsa-let-7f-1*	hsa-let-7f-1	9	20177422
hsa-let-7f-1*	hsa-let-7f-1	9	17728006
hsa-let-7f-2*	hsa-let-7f-2	X	20177422
hsa-let-7f-2*	hsa-let-7f-2	X	17728006
hsa-let-7g	hsa-let-7g	3	20818338
hsa-let-7g	hsa-let-7g	3	20177422
hsa-let-7g	hsa-let-7g	3	17728006
hsa-let-7g*	hsa-let-7g	3	20818338
hsa-let-7g*	hsa-let-7g	3	20177422
hsa-let-7g*	hsa-let-7g	3	17728006
hsa-let-7i	hsa-let-7i	12	20177422
hsa-let-7i	hsa-let-7i	12	17728006
hsa-let-7i*	hsa-let-7i	12	20177422
hsa-let-7i*	hsa-let-7i	12	17728006
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-10b	hsa-mir-10b	2	19585508
hsa-miR-10b*	hsa-mir-10b	2	19585508
hsa-miR-125a-3p	hsa-mir-125a	19	19881956
hsa-miR-125a-3p	hsa-mir-125a	19	19702827
hsa-miR-125a-5p	hsa-mir-125a	19	19881956
hsa-miR-125a-5p	hsa-mir-125a	19	19702827
hsa-miR-126	hsa-mir-126	9	20097187
hsa-miR-126*	hsa-mir-126	9	20097187
hsa-miR-126*	hsa-mir-126	9	19493678
hsa-miR-137	hsa-mir-137	1	20818338
hsa-miR-138	hsa-mir-138-2	16	19597153
hsa-miR-138	hsa-mir-138-1	3	19597153
hsa-miR-145	hsa-mir-145	5	20097187
hsa-miR-145	hsa-mir-145	5	19493678
hsa-miR-145*	hsa-mir-145	5	20097187
hsa-miR-145*	hsa-mir-145	5	19493678
hsa-miR-146a	hsa-mir-146a	5	20124483
hsa-miR-146a	hsa-mir-146a	5	19585508
hsa-miR-146a*	hsa-mir-146a	5	20124483
hsa-miR-146a*	hsa-mir-146a	5	19585508
hsa-miR-146b-3p	hsa-mir-146b	10	21266476
hsa-miR-146b-3p	hsa-mir-146b	10	19585508
hsa-miR-146b-5p	hsa-mir-146b	10	21266476
hsa-miR-146b-5p	hsa-mir-146b	10	19585508
hsa-miR-155	hsa-mir-155	21	20818338
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	20818338
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-182	hsa-mir-182	7	19493678
hsa-miR-182*	hsa-mir-182	7	19493678
hsa-miR-183	hsa-mir-183	7	19493678
hsa-miR-183	hsa-mir-183	7	19047896
hsa-miR-183*	hsa-mir-183	7	19493678
hsa-miR-183*	hsa-mir-183	7	19047896
hsa-miR-18b	hsa-mir-18b	0	20818338
hsa-miR-18b*	hsa-mir-18b	0	20818338
hsa-miR-192	hsa-mir-192	11	19047896
hsa-miR-192*	hsa-mir-192	11	19047896
hsa-miR-200a	hsa-mir-200a	1	19671845
hsa-miR-200a*	hsa-mir-200a	1	19671845
hsa-miR-200b	hsa-mir-200b	1	19671845
hsa-miR-200b*	hsa-mir-200b	1	19671845
hsa-miR-200c	hsa-mir-200c	12	19671845
hsa-miR-200c*	hsa-mir-200c	12	19671845
hsa-miR-206	hsa-mir-206	6	19423651
hsa-miR-20a	hsa-mir-20a	13	20818338
hsa-miR-20a*	hsa-mir-20a	13	20818338
hsa-miR-21	hsa-mir-21	17	21063030
hsa-miR-21	hsa-mir-21	17	20113523
hsa-miR-21	hsa-mir-21	17	20048743
hsa-miR-21	hsa-mir-21	17	19597153
hsa-miR-21	hsa-mir-21	17	19493678
hsa-miR-21*	hsa-mir-21	17	21063030
hsa-miR-21*	hsa-mir-21	17	20113523
hsa-miR-21*	hsa-mir-21	17	20048743
hsa-miR-21*	hsa-mir-21	17	19597153
hsa-miR-21*	hsa-mir-21	17	19493678
hsa-miR-210	hsa-mir-210	11	19493678
hsa-miR-212	hsa-mir-212	17	20856931
hsa-miR-25	hsa-mir-25	7	20818338
hsa-miR-25*	hsa-mir-25	7	20818338
hsa-miR-27a	hsa-mir-27a	19	21156786
hsa-miR-27a*	hsa-mir-27a	19	21156786
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-32	hsa-mir-32	9	20818338
hsa-miR-32*	hsa-mir-32	9	20818338
hsa-miR-328	hsa-mir-328	16	20818338
hsa-miR-331-3p	hsa-mir-331	12	20931396
hsa-miR-342-3p	hsa-mir-342	14	20818338
hsa-miR-342-5p	hsa-mir-342	14	20818338
hsa-miR-34c-3p	hsa-mir-34c	11	20818338
hsa-miR-34c-5p	hsa-mir-34c	11	20818338
hsa-miR-424	hsa-mir-424	X	17889671
hsa-miR-424*	hsa-mir-424	X	17889671
hsa-miR-429	hsa-mir-429	1	19671845
hsa-miR-448	hsa-mir-448	X	20798686
hsa-miR-495	hsa-mir-495	14	20818338
hsa-miR-7	hsa-mir-7-1	9	21156648
hsa-miR-7	hsa-mir-7-2	15	21156648
hsa-miR-7	hsa-mir-7-3	19	21156648
hsa-miR-7	hsa-mir-7-1	9	20978205
hsa-miR-7	hsa-mir-7-2	15	20978205
hsa-miR-7	hsa-mir-7-3	19	20978205
hsa-miR-7	hsa-mir-7-1	9	20931396
hsa-miR-7	hsa-mir-7-2	15	20931396
hsa-miR-7	hsa-mir-7-3	19	20931396
hsa-miR-7	hsa-mir-7-1	9	19073608
hsa-miR-7	hsa-mir-7-2	15	19073608
hsa-miR-7	hsa-mir-7-3	19	19073608
hsa-miR-7	hsa-mir-7-1	9	18483236
hsa-miR-7	hsa-mir-7-2	15	18483236
hsa-miR-7	hsa-mir-7-3	19	18483236
hsa-miR-7	hsa-mir-7-1	9	16377567
hsa-miR-7	hsa-mir-7-2	15	16377567
hsa-miR-7	hsa-mir-7-3	19	16377567
hsa-miR-7-1*	hsa-mir-7-1	9	18483236

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1036	Unknown	pSILAC	miR-16	EGFR	down 50-25%	18668040
1153	Unknown	pSILAC	miR-1	EGFR	down 75-50%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000146648		n_a	n_a	n_a	"epithelium, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000146648		n_a	n_a	n_a	"epithelium, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"

Cis-Nats regulation

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Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
24009	mRNA	EGFR	chr7	54860933	55049239	186	mRNA		chr7	55021652	55030836	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for EGFR

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics