AutismKB 2.0

Annotation Detail for MLKL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MLKL ( FLJ34389 )
Gene Full Name: mixed lineage kinase domain-like
Band: 16q22.3
Quick LinksEntrez ID:197259; OMIM: NA; Uniprot ID:MLKL_HUMAN; ENSEMBL ID: ENSG00000168404; HGNC ID: 26617
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
125Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
52Phosphoserine(PKG)HMM predict
55O-linkedHMM predict
81N-linkedHMM predict
84N-linkedHMM predict
92Phosphoserine(ATM)HMM predict
128Phosphoserine(ATM)HMM predict
275Phosphothreonine(MAPK)HMM predict
357Phosphothreonine(PKC)HMM predict
376Phosphotyrosine(INSR)HMM predict
376Phosphotyrosine(Jak)HMM predict
439Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_152649
  • Location:chr16 73263261-73292289
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TAF HelaGSE8489 73292459 73292706 247 293
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 73286910 73287756 846 0
Fos K562GSE19551 73287003 73287836 833 0
Oct1 HelaGSE14283 73265207 73265237 30 0
PHF8 293TGSE20725 73287066 73287795 729 0
TAF HelaGSE8489 73291383 73292096 713 0
USF1 HepG2E 73283675 73284111 436 0
USF1 HepG2E 73286581 73287258 677 0
USF1 HepG2E 73289768 73290086 318 0
USF2 HepG2E 73286581 73287258 677 0
hScc1 BcellGSE12603 73291773 73292357 584 0
p130 QuiescentGSE19898 73287351 73287884 533 0
p130 SenescentGSE19898 73287205 73287842 637 0
p130 shRbQuiescentGSE19898 73287318 73288074 756 0
p130 shRbSenescentGSE19898 73287214 73288013 799 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018