AutismKB 2.0

Annotation Detail for EIF4B


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Basic Information Top
Gene Symbol:EIF4B ( EIF-4B,PRO1843 )
Gene Full Name: eukaryotic translation initiation factor 4B
Band: 12q13.13
Quick LinksEntrez ID:1975; OMIM: 603928; Uniprot ID:IF4B_HUMAN; ENSEMBL ID: ENSG00000063046; HGNC ID: 3285
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
16Phosphoserine.
93Phosphoserine.
192Phosphoserine.
211Phosphotyrosine.
219Phosphoserine.
283Phosphoserine.
406Phosphoserine.
420Phosphothreonine.
422Phosphoserine.
424Phosphoserine.
425Phosphoserine.
445Phosphoserine.
459Phosphoserine.
461Phosphothreonine.
462Phosphoserine.
495Phosphoserine.
497Phosphoserine (By similarity).
498Phosphoserine.
500Phosphothreonine.
504Phosphoserine.
586N6-acetyllysine.
597Phosphoserine.
Location(AA) Modifications Resource
93Phosphoserine.Swiss-Prot 53.0
93PhosphoserinePhospho.ELM 6.0
406PhosphoserinePhospho.ELM 6.0
406Phosphoserine.Swiss-Prot 53.0
422Phosphoserine (p70S6K)Phospho.ELM 6.0
425PhosphoserinePhospho.ELM 6.0
445Phosphoserine.Swiss-Prot 53.0
445PhosphoserinePhospho.ELM 6.0
459PhosphoserinePhospho.ELM 6.0
459Phosphoserine.Swiss-Prot 53.0
498Phosphoserine.Swiss-Prot 53.0
498PhosphoserinePhospho.ELM 6.0
504PhosphoserinePhospho.ELM 6.0
504Phosphoserine.Swiss-Prot 53.0
597Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
33Phosphotyrosine(EGFR)HMM predict
39Phosphoserine(IKK)HMM predict
63Phosphotyrosine(Syk)HMM predict
63Phosphotyrosine(EGFR)HMM predict
93Phosphoserine(CDC2)HMM predict
141Phosphotyrosine(EGFR)HMM predict
149Phosphoserine(CK1)HMM predict
155Phosphoserine(CK1)HMM predict
237Phosphotyrosine(INSR)HMM predict
237Phosphotyrosine(Syk)HMM predict
258Phosphotyrosine(Syk)HMM predict
266SulfotyrosineHMM predict
266Phosphotyrosine(INSR)HMM predict
298Phosphotyrosine(Syk)HMM predict
302Phosphotyrosine(Syk)HMM predict
309Phosphoserine(IKK)HMM predict
316SulfotyrosineHMM predict
317Phosphoserine(CK2)HMM predict
321Phosphotyrosine(Syk)HMM predict
340Phosphoserine(CK2)HMM predict
341Phosphothreonine(CDK)HMM predict
341PhosphothreonineHMM predict
347Phosphoserine(IKK)HMM predict
348Phosphoserine(CK1)HMM predict
348O-linkedHMM predict
348Phosphoserine(IKK)HMM predict
352Phosphoserine(IKK)HMM predict
352Phosphoserine(ATM)HMM predict
355O-linkedHMM predict
406PhosphoserineHMM predict
406Phosphoserine(PKB)HMM predict
406Phosphoserine(PKC)HMM predict
418Phosphoserine(CK1)HMM predict
420Phosphothreonine(PKC)HMM predict
422Phosphoserine(CK1)HMM predict
422Phosphoserine(IKK)HMM predict
422Phosphoserine(CAMK2)HMM predict
425O-linkedHMM predict
425Phosphoserine(ATM)HMM predict
425Phosphoserine(IKK)HMM predict
429O-linkedHMM predict
442Phosphoserine(PKG)HMM predict
445Phosphoserine(CK1)HMM predict
448N-linkedHMM predict
452N-linkedHMM predict
459Phosphoserine(MAPK)HMM predict
459Phosphoserine(IKK)HMM predict
461O-linkedHMM predict
498Phosphoserine(CK2)HMM predict
498Phosphoserine(CK1)HMM predict
504Phosphoserine(IKK)HMM predict
537O-linkedHMM predict
542N-linkedHMM predict
543Phosphoserine(CDC2)HMM predict
572Phosphoserine(CK1)HMM predict
588O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001417
  • Location:chr12 51686489-51722258
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 51673382 51673660 278 12969
FOXA1 MCF7GSE15244 51673382 51673694 312 12952
H3ac HepG2E 51673382 51674052 670 12773
H3ac HepG2E 51684727 51685391 664 1431
PHF8 293TGSE20725 51685626 51687074 1448 140
RARA MCF7GSE15244 51673382 51674052 670 12773
RARG MCF7GSE15244 51673382 51673694 312 12952
Rb SenescentGSE19898 51685979 51686727 748 137
TAF HelaGSE8489 51670256 51671045 789 15839
TAF HelaGSE8489 51684727 51685391 664 1431
TAF k562GSE8489 51685230 51685391 161 1179
USF1 HepG2E 51684727 51685391 664 1431
USF2 HepG2E 51686109 51686480 371 195
hScc1 BcellGSE12603 51686109 51686593 484 139
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 51722669 51722851 182 502
FOXA1 MCF7GSE15244 51723949 51724198 249 1815
RARG MCF7GSE15244 51722408 51723328 920 610
RARG MCF7GSE15244 51723949 51724198 249 1815
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 51718746 51718994 248 0
CTCF CD4SISSRdata 51718746 51718994 248 0
ETS1 JurkatGSE17954 51685755 51687652 1897 0
FOXA1 MCF7GSE15244 51686109 51687205 1096 0
H3ac HepG2E 51686109 51688776 2667 0
H3ac HepG2E 51689699 51690667 968 0
PHF8 Hs68plusFBSGSE20725 51685749 51687424 1675 0
RARG MCF7GSE15244 51707880 51708358 478 0
USF1 HepG2E 51686109 51688093 1984 0
USF2 HepG2E 51686819 51687873 1054 0
p130 QuiescentGSE19898 51686416 51687101 685 0
p130 SenescentGSE19898 51685993 51687074 1081 0
p130 shRbQuiescentGSE19898 51685992 51687042 1050 0
p130 shRbSenescentGSE19898 51687039 51687387 348 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
6046 mRNA EIF4B chr12 51686518 51722259 1248 HTC PRO1843 chr12 51720851 51722099Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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