AutismKB 2.0

Annotation Detail for EIF4E


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EIF4E ( CBP,EIF4E1,EIF4EL1,EIF4F,MGC111573 )
Gene Full Name: eukaryotic translation initiation factor 4E
Band: 4q23
Quick LinksEntrez ID:1977; OMIM: 133440; Uniprot ID:IF4E_HUMAN; ENSEMBL ID: ENSG00000151247; HGNC ID: 3287
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
209Phosphoserine; by PKC.
Location(AA) Modifications Resource
53PhosphoserinePhospho.ELM 6.0
209Phosphoserine (by PKC).Swiss-Prot 53.0
209Phosphoserine (Mnk1;Mnk2)Phospho.ELM 6.0
Location(AA) Modification Resource
9O-linkedHMM predict
9O-linkedHMM predict
9O-linkedHMM predict
34Phosphotyrosine(EGFR)HMM predict
53Phosphoserine(CK1)HMM predict
141Phosphoserine(CK2)HMM predict
145SulfotyrosineHMM predict
207Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001968
  • Location:chr4 100020235-100070138
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 100080102 100080386 284 10106
Oct1 H2O2-HelaGSE14283 100080444 100080482 38 10325
Oct1 HelaGSE14283 100080442 100080487 45 10326
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc K562GSE19551 100001377 100001752 375 18671
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 100068467 100069249 782 0
ER E2-MCF7GSE14664 100039012 100039053 41 0
ER E2-MCF7GSE14664 100039218 100039254 36 0
ETS1 JurkatGSE17954 100067770 100070057 2287 0
Fos K562GSE19551 100069030 100069820 790 0
H3K4me3 colorectalcancer 100067870 100068699 829 0
H3K4me3 colorectalcancer 100069865 100070109 244 0
H3ac HepG2E 100067870 100069090 1220 0
H3ac HepG2E 100069362 100070665 1303 0
Myc K562GSE19551 100032102 100032374 272 0
Oct1 H2O2-HelaGSE14283 100050143 100050178 35 0
Oct1 H2O2-HelaGSE14283 100065315 100065342 27 0
Oct1 HelaGSE14283 100050142 100050182 40 0
Oct1 HelaGSE14283 100065314 100065343 29 0
PHF8 293TGSE20725 100068174 100070136 1962 0
USF1 HepG2E 100067870 100070908 3038 0
USF2 HepG2E 100067870 100070534 2664 0
hScc1 BcellGSE12603 100068532 100069403 871 0
hScc1 BcellGSE12603 100069968 100070109 141 0
p63 keratinocytesGSE17611 100030696 100031542 846 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 17656684
hsa-let-7a hsa-let-7a-2 11 17656684
hsa-let-7a hsa-let-7a-3 22 17656684
hsa-let-7a hsa-let-7a-1 9 17524464
hsa-let-7a hsa-let-7a-2 11 17524464
hsa-let-7a hsa-let-7a-3 22 17524464
hsa-let-7a* hsa-let-7a-1 9 17656684
hsa-let-7a* hsa-let-7a-3 22 17656684
hsa-let-7a* hsa-let-7a-1 9 17524464
hsa-let-7a* hsa-let-7a-3 22 17524464
hsa-let-7b hsa-let-7b 22 17656684
hsa-let-7b hsa-let-7b 22 17524464
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 17656684
hsa-let-7b* hsa-let-7b 22 17524464
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7c hsa-let-7c 21 17656684
hsa-let-7c hsa-let-7c 21 17524464
hsa-let-7c* hsa-let-7c 21 17656684
hsa-let-7c* hsa-let-7c 21 17524464
hsa-let-7d hsa-let-7d 9 17656684
hsa-let-7d hsa-let-7d 9 17524464
hsa-let-7d* hsa-let-7d 9 17656684
hsa-let-7d* hsa-let-7d 9 17524464
hsa-let-7e hsa-let-7e 19 17656684
hsa-let-7e hsa-let-7e 19 17524464
hsa-let-7e* hsa-let-7e 19 17656684
hsa-let-7e* hsa-let-7e 19 17524464
hsa-let-7f hsa-let-7f-1 9 17656684
hsa-let-7f hsa-let-7f-2 X 17656684
hsa-let-7f hsa-let-7f-1 9 17524464
hsa-let-7f hsa-let-7f-2 X 17524464
hsa-let-7f-1* hsa-let-7f-1 9 17656684
hsa-let-7f-1* hsa-let-7f-1 9 17524464
hsa-let-7f-2* hsa-let-7f-2 X 17656684
hsa-let-7f-2* hsa-let-7f-2 X 17524464
hsa-let-7g hsa-let-7g 3 17656684
hsa-let-7g hsa-let-7g 3 17524464
hsa-let-7g* hsa-let-7g 3 17656684
hsa-let-7g* hsa-let-7g 3 17524464
hsa-let-7i hsa-let-7i 12 17656684
hsa-let-7i hsa-let-7i 12 17524464
hsa-let-7i* hsa-let-7i 12 17656684
hsa-let-7i* hsa-let-7i 12 17524464
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-141 hsa-mir-141 12 21238942
hsa-miR-141* hsa-mir-141 12 21238942
hsa-miR-145 hsa-mir-145 5 21092188
hsa-miR-145* hsa-mir-145 5 21092188
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1037 Unknown pSILAC miR-16 EIF4E down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000151247 n_a n_a n_a "lymphocyte, muscle cell" "malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018