AutismKB 2.0

Annotation Detail for EIF4G1


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Basic Information Top
Gene Symbol:EIF4G1 ( DKFZp686A1451,EIF-4G1,EIF4F,EIF4G,EIF4GI,P220 )
Gene Full Name: eukaryotic translation initiation factor 4 gamma, 1
Band: 3q27.1
Quick LinksEntrez ID:1981; OMIM: 600495; Uniprot ID:IF4G1_HUMAN; ENSEMBL ID: ENSG00000114867; HGNC ID: 3296
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
205Phosphothreonine.
207Phosphothreonine.
223Phosphothreonine.
450Phosphoserine.
594Phosphotyrosine.
647Phosphothreonine.
1092Phosphoserine.
1095N6-acetyllysine.
1145Phosphoserine.
1147Phosphoserine.
1185Phosphoserine.
1187Phosphoserine.
1188N6-acetyllysine.
1209Phosphoserine.
1231Phosphoserine.
1238Phosphoserine.
1596Phosphoserine.
Location(AA) Modifications Resource
205Phosphothreonine (By similarity).Swiss-Prot 53.0
207Phosphothreonine (By similarity).Swiss-Prot 53.0
594Phosphotyrosine.Swiss-Prot 53.0
594PhosphotyrosinePhospho.ELM 6.0
1093PhosphoserinePhospho.ELM 6.0
1146Phosphoserine.Swiss-Prot 53.0
1146PhosphoserinePhospho.ELM 6.0
1148Phosphoserine.Swiss-Prot 53.0
1148PhosphoserinePhospho.ELM 6.0
1186PhosphoserinePhospho.ELM 6.0
1186Phosphoserine.Swiss-Prot 53.0
1188PhosphoserinePhospho.ELM 6.0
1210PhosphoserinePhospho.ELM 6.0
1210Phosphoserine.Swiss-Prot 53.0
1232Phosphoserine.Swiss-Prot 53.0
1232PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
15Phosphoserine(CDK)HMM predict
15Phosphoserine(CDC2)HMM predict
15O-linkedHMM predict
34O-linkedHMM predict
39O-linkedHMM predict
39O-linkedHMM predict
43Phosphothreonine(MAPK)HMM predict
60Phosphoserine(IKK)HMM predict
68Phosphoserine(PKG)HMM predict
99Phosphoserine(ATM)HMM predict
113Phosphotyrosine(INSR)HMM predict
141Phosphotyrosine(INSR)HMM predict
179Phosphothreonine(PKC)HMM predict
204O-linkedHMM predict
204Phosphoserine(IKK)HMM predict
205O-linkedHMM predict
207Phosphothreonine(CDK)HMM predict
207Phosphothreonine(MAPK)HMM predict
207O-linkedHMM predict
253Phosphoserine(ATM)HMM predict
255Phosphoserine(CK1)HMM predict
255O-linkedHMM predict
257Phosphoserine(CK1)HMM predict
257Phosphoserine(ATM)HMM predict
260Phosphoserine(CK1)HMM predict
260Phosphoserine(IKK)HMM predict
260O-linkedHMM predict
261Phosphoserine(CDK)HMM predict
261Phosphoserine(ATM)HMM predict
261Phosphoserine(IKK)HMM predict
261Phosphoserine(CDC2)HMM predict
261O-linkedHMM predict
263Phosphoserine(IKK)HMM predict
263O-linkedHMM predict
263Phosphoserine(CDC2)HMM predict
265Phosphothreonine(MAPK)HMM predict
265O-linkedHMM predict
265O-linkedHMM predict
267Phosphoserine(CDC2)HMM predict
267O-linkedHMM predict
301Phosphothreonine(MAPK)HMM predict
314Phosphoserine(CDC2)HMM predict
318Phosphothreonine(MAPK)HMM predict
341O-linkedHMM predict
341Phosphoserine(CK1)HMM predict
343Phosphoserine(CDC2)HMM predict
349Phosphothreonine(MAPK)HMM predict
349O-linkedHMM predict
376Phosphoserine(CK1)HMM predict
377O-linkedHMM predict
388O-linkedHMM predict
390O-linkedHMM predict
409Phosphoserine(CDC2)HMM predict
419Phosphoserine(CK2)HMM predict
431Phosphoserine(IKK)HMM predict
431O-linkedHMM predict
439O-linkedHMM predict
439O-linkedHMM predict
441O-linkedHMM predict
447O-linkedHMM predict
447O-linkedHMM predict
449O-linkedHMM predict
450Phosphoserine(CDC2)HMM predict
450Phosphoserine(IKK)HMM predict
561O-linkedHMM predict
645N-linkedHMM predict
647Phosphothreonine(MAPK)HMM predict
647Phosphothreonine(CDK)HMM predict
647Phosphothreonine(CDC2)HMM predict
685MethylarginineHMM predict
705Phosphoserine(ATM)HMM predict
831O-linkedHMM predict
896Phosphoserine(PKG)HMM predict
932Phosphoserine(CK1)HMM predict
1042O-linkedHMM predict
1055Phosphothreonine(PKC)HMM predict
1078Phosphoserine(IKK)HMM predict
1180Phosphothreonine(MAPK)HMM predict
1186Phosphoserine(PKA)HMM predict
1188Phosphoserine(CK1)HMM predict
1200Phosphoserine(ATM)HMM predict
1232Phosphoserine(CDC2)HMM predict
1232Phosphoserine(CDK)HMM predict
1272Phosphoserine(MAPK)HMM predict
1468N-linkedHMM predict
1496Phosphothreonine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_182917
  • Location:chr3 185515787-185535838
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 185516692 185516952 260 0
CTCF G2GSE9613 185517358 185517696 338 0
CTCF G2GSE9613 185519881 185520793 912 0
H3ac HepG2E 185516038 185517869 1831 0
PolII HeLaGSE12783 185514673 185517013 2340 0
TFAP2C MCF7GSE21234 185519786 185520874 1088 0
p130 shRbQuiescentGSE19898 185519900 185520179 279 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 21378162
hsa-let-7a hsa-let-7a-2 11 21378162
hsa-let-7a hsa-let-7a-3 22 21378162
hsa-let-7a* hsa-let-7a-1 9 21378162
hsa-let-7a* hsa-let-7a-3 22 21378162
hsa-let-7b hsa-let-7b 22 21378162
hsa-let-7b* hsa-let-7b 22 21378162
hsa-let-7c hsa-let-7c 21 21378162
hsa-let-7c* hsa-let-7c 21 21378162
hsa-let-7d hsa-let-7d 9 21378162
hsa-let-7d* hsa-let-7d 9 21378162
hsa-let-7e hsa-let-7e 19 21378162
hsa-let-7e* hsa-let-7e 19 21378162
hsa-let-7f hsa-let-7f-1 9 21378162
hsa-let-7f hsa-let-7f-2 X 21378162
hsa-let-7f-1* hsa-let-7f-1 9 21378162
hsa-let-7f-2* hsa-let-7f-2 X 21378162
hsa-let-7g hsa-let-7g 3 21378162
hsa-let-7g* hsa-let-7g 3 21378162
hsa-let-7i hsa-let-7i 12 21378162
hsa-let-7i* hsa-let-7i 12 21378162
hsa-miR-98 hsa-mir-98 X 21378162
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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