Annotation Detail for ELAVL2

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Basic Information Top

Gene Symbol:	ELAVL2 ( HEL-N1,HELN1,HUB )
Gene Full Name:	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
Band:	9p21.3
Quick Links	Entrez ID:1993; OMIM: 601673; Uniprot ID:ELAV2_HUMAN; ENSEMBL ID: ENSG00000107105; HGNC ID: 3313
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:15 results

Location(AA)	Modification
221	Phosphoserine.

Location(AA)	Modification	Resource
12	N-linked	HMM predict
13	N-linked	HMM predict
16	N-linked	HMM predict
24	N-linked	HMM predict
27	Phosphoserine(CDK)	HMM predict
27	Phosphoserine(CDC2)	HMM predict
49	N-linked	HMM predict
87	Phosphotyrosine(INSR)	HMM predict
137	Phosphothreonine(PKC)	HMM predict
153	Phosphothreonine(PKC)	HMM predict
205	N-linked	HMM predict
207	Phosphoserine(ATM)	HMM predict
211	N-linked	HMM predict
221	Phosphoserine(CDC2)	HMM predict
340	Phosphotyrosine(INSR)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_004432
Location:chr9 23680104-23816062
strand:-

Upstream the gene:10 results
Downstream the gene:0 results
Inside the gene:18 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K27me3	colorectal	cancer	23819964	23822381	2417	5110
NRSF	Jurkat	GSE13047	23819051	23820552	1501	3739
NRSF	mAb	Jurkat	23814092	23822753	8661	2360
NRSF-mono	Jurkat	QuESTdata	23819167	23819507	340	3275
NRSF-mono	Jurkat	QuESTdata	23819514	23820475	961	3932
NRSF-poly	Jurkat	QuESTdata	23819460	23820494	1034	3915
Oct1	H2O2-Hela	GSE14283	23818916	23818944	28	2868
P300	T30-glioblastoma	GSE21026	23815997	23816923	926	398
p130	Quiescent	GSE19898	23816227	23816613	386	358
p130	shRbSenescent	GSE19898	23816244	23816591	347	355

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	T0-glioblastoma	GSE21026	23689648	23690216	568	0
CBP	T0-glioblastoma	GSE21026	23769979	23770202	223	0
CBP	T30-glioblastoma	GSE21026	23769969	23770231	262	0
ER	E2-MCF7	GSE14664	23688846	23688882	36	0
H3K27me3	colorectal	cancer	23812530	23814359	1829	0
H3K27me3	colorectal	cancer	23814603	23815668	1065	0
H3K4me3	colorectal	cancer	23815277	23816446	1169	0
NRSF	Jurkat	GSE13047	23729649	23730172	523	0
NRSF	mAb	Jurkat	23727589	23731458	3869	0
NRSF	mAb	Jurkat	23731952	23732346	394	0
NRSF-mono	Jurkat	QuESTdata	23729648	23730134	486	0
NRSF-mono	Jurkat	QuESTdata	23814737	23815064	327	0
NRSF-poly	Jurkat	QuESTdata	23729588	23730085	497	0
NRSF-poly	Jurkat	QuESTdata	23814865	23815244	379	0
Oct1	Hela	GSE14283	23691782	23691815	33	0
Oct1	Hela	GSE14283	23789911	23789943	32	0
P300	T0-glioblastoma	GSE21026	23759026	23760109	1083	0
p63	keratinocytes	GSE17611	23759206	23760294	1088	0

Validated miRNA targets

miR Walk:7 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-10a	hsa-mir-10a	17	20309390
hsa-miR-10a*	hsa-mir-10a	17	20309390
hsa-miR-9	hsa-mir-9-1	1	21368052
hsa-miR-9	hsa-mir-9-2	5	21368052
hsa-miR-9	hsa-mir-9-3	15	21368052
hsa-miR-9*	hsa-mir-9-2	5	21368052
hsa-miR-9*	hsa-mir-9-3	15	21368052

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
26281	mRNA		chr9	23722980	23723170	190	mRNA	ELAVL2	chr9	23681983	23816301	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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